CAS: 1620576-64-8; 1-(4-(5-(5-Amino-6-(5-(Tert-Butyl)-1,3,4-Oxadiazol-2-yl)Pyrazin-2-yl)-1-Ethyl-1H-1,2,4-Triazol-3-yl)Piperidin-1-yl)-3-Hydroxypropan-1-One

合成参考文献

参考文献:10.1016/j.bmcl.2015.10.002
摘要:Barlaam B, Cosulich S, Delouvrié B, Ellston R, Fitzek M, Germain H, Green S, Hancox U, Harris CS, Hudson K, Lambert-van der Brempt C, Lebraud H, Magnien F, Lamorlette M, Le Griffon A, Morgentin R, Ouvry G, Page K, Pasquet G, Polanska U, Ruston L, Saleh T, Vautier M, Ward L. Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers. Bioorganic & Medicinal Chemistry Letters. 2015 Nov;25(22):5155–62. doi: 10.1016/j.bmcl.2015.10.002.