CAS: 155-38-4; Noformycin
- 英文名称Noformycin
- 中文名称5-氨基-N-(3-氨基-3-亚氨基丙基)-3,4-二氢-2H-吡咯-2-甲酰胺
- IUPAC名称(S)-5-amino-N-(3-amino-3-iminopropyl)-3,4-dihydro-2H-pyrrole-2-carboxamide
- 其它别名Noformicin; 5-Amino-N-(3-Amino-3-Iminopropyl)-3,4-Dihydro-2H-Pyrrole-2-Carboxamide; Noformycin; 2H-Pyrrole-2-Carboxamide, 5-Amino-N-(3-Amino-3-Iminopropyl)-3,4-Dihydro-, (2S)-
- CAS编号155-38-4
- MFCD编号:MFCD28339320
- FDA UNII编号:T2B48SB35T
- 分子式:C8H15N5O分子量:197.24
- 产品CID: 769756
- 产品分类有机原料 → 有机酸及其衍生物 → 羧酸及其衍生物
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2912110000-甲醛
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2921211000-乙二胺
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专利信息
专利号:US-6683189-B1
优先权日:1996-02-26
标 题 :Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
发明人：DERVAN PETER B; BAIRD ELDON
权利人:CALIFORNIA INST OF TECHN
摘要:The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.
专利号:US-6545162-B1
优先权日:1996-02-26
标 题:Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
专利号:WO-9730975-A2
优先权日:1996-02-26
标题:Method for the synthesis of poly-pyrrole and poly-imidazole carboxamides on a solid support
专利号:EP-0885189-A2
优先权日:1996-02-26
标 题 :Method for the synthesis of poly-pyrrole and poly-imidazole carboxamides on a solid support
专利号:US-6090947-A
优先权日:1996-02-26
标题:Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1021/jm00265a027
摘要:Diana GD. A synthesis of noformycin. J Med Chem. 1973 Jul;16(7):857–9. doi: 10.1021/jm00265a027.
参考文献:10.1021/jm00267a022
摘要:Diana GD, Salvador UJ, Zalay ES, Pancic F. Synthesis and antiviral activity of homologs of noformycin. J Med Chem. 1973 Sep;16(9):1050–3. doi: 10.1021/jm00267a022.
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