CAS: 14985-44-5; (2R,3S,5R)-5-(6-Amino-8-Bromo-9H-Purin-9-yl)-2-(Hydroxymethyl)Tetrahydrofuran-3-Ol

相似化合物

2946-39-6 4291-63-8 958-09-8

上下游产品

2'-deoxy-D-adenosine N-[8-Bromo-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide 8-Azido-2'-deoxyadenosine 8-bromoadenine 5-(6-amino-8-bromo-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

2'-脱氧腺苷置于bromoisocyanuric Acid Monosodium Salt体系中,用 水,N,N-二甲基甲酰胺 用作溶剂,化学反应 1.5H,以61%的收率获得8-溴-2'-脱氧腺苷
参考文献:基因毒性 C8-Arylamino-2'-Deoxyadenosines 作为潜在的烷基化剂诱导 Dna 链间交联
标题:基因毒性 C8-Arylamino-2'-Deoxyadenosines 作为潜在的烷基化剂诱导 Dna 链间交联
摘要:Dna 链间交联 (Icl) 极其有害且结构多样,推动了 Icl 修复途径的发展.因此,发现 Icl 诱导剂对于 Icl 修复途径和范可尼贫血(一种由 Icl 修复基因突变引起的遗传病)的表征至关重要.尽管几项研究指出氧化应激是 Icl 的一个原因,但氧化应激诱导的交联事件的特征仍然很差.此外,多环芳香胺,一种强效环境致癌物,与 Icl 的产生有关,但它们的身份和序列尚不清楚.为了缩小这一知识差距,我们测试了 Icl 是否是由 8-Arylamino-2'-Deoxyadenosine (Arnhda) 损伤(由芳氨基致癌物产生的加合物)氧化引起的.在此处,我们报告 Arnhda 作为潜在的交联剂在氧化条件下产生 Icl.由 8-氨基腺嘌呤而非 8-氨基鸟嘌呤形成 Icl,突出了 8-氨基嘌呤介导的 Icl 产生的特异性.在活性氧 (Ros) 亚硝基过氧碳酸酯的影响下,Arnhda (Ar
Doi:10.1021/jacs.1C07234

专利信息

专利号:WO-2012164484-A1
优先权日:2011-05-30
标 题:Adenosine or deoxyadenosine derivatives modified at position 8 and a method of synthesis thereof
发明人：CAPOBIANCO MASSIMO LUIGI; NAVACCHIA MARIA LUISA
权利人:CONSIGLIO NAZIONALE RICERCHE; CAPOBIANCO MASSIMO LUIGI; NAVACCHIA MARIA LUISA
摘要:New derivatives of adenosine and deoxyadenosine modified at position 8 of the purine ring, of general formula (I) are described, which are suitable to be conjugated with functional molecules such as chromophores, fluorophores and intercalating residues, and suitable to be incorporated within synthetic oligonucleotides. A method for the synthesis of the above-mentioned derivatives is also described, which allows the obtainment thereof in high yields and by simple methods. Formula (I), wherein Z is selected from (a) and (b).