CAS: 13925-12-7; Myxin

上下游产品

1,6-吩嗪二醇 5,10-二氧化物 Iodinin 68-81-5
5,6-Dihydroxyphenazin-1-One 69-86-3
1,6-Dimethoxy-Phenazin-5,10-Dioxid 13925-11-6
1-Hydroxy-6-Methoxyphenazine 13129-58-3
1,6-二甲氧基吩嗪 1,6-Dimethoxyphenazine 13398-79-3
1,6-二羟基吩嗪 Phenazine-1,6-Diol 69-48-7

📜2-硝基苯甲醚置于aluminum (III) Chloride,间氯过氧苯甲酸,Potassium Hydroxide体系中,用 二氯甲烷,苯 用作溶剂,化学反应 10.0H,反应生成堆囊粘菌素
参考文献:Dna链切割由吩嗪二-ñ下喜氧和厌氧条件氧化物天然产物myxin
标题:Dna链切割由吩嗪二-ñ下喜氧和厌氧条件氧化物天然产物myxin
摘要:杂环n-氧化物是一类有趣的抗肿瘤药物,可选择性杀死实体瘤中的缺氧细胞.这类化合物先导药物替拉帕明的低氧选择性活性源于其将细胞内单电子还原为对氧敏感的药物自由基中间体的能力.在分子氧的存在下,自由基中间体被反氧化为母体分子.在缺氧条件下,延长的药物自由基中间体寿命可以通过"脱氧"机制将其转化为具有高度细胞毒性的破坏dna的中间体,该机制涉及从其n-氧化物基团之一中损失氧气.天然产物粘菌素是吩嗪二氮在有氧条件下对多种生物体均表现出强大的抗生素活性的氧化物.鉴于目前对杂环n-氧化物作为在低氧条件下有选择地起作用的物质的看法,令人惊讶的是从sorangium中鉴定出了毒素.提取物基于其在有氧条件下的抗生素特性.因此,我们着手研究粘菌素生物学活性的分子机制.我们发现,在有氧和无氧条件下,毒素都可引起生物还原活化的自由基介导的dna链断裂.我们的证据表明,链断裂是通过脱氧代谢发生的.我们表明,在有氧和
Doi:10.1021/tx2004213

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-2024197774-A1
优先权日:2021-04-16
标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
发明人：LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
权利人:UNIV TEXAS
摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

专利号:WO-2024010785-A1
优先权日:2022-07-08
标 题:Ketoreductase enzymes for the synthesis of 1,3-diol substituted indanes
发明人：CAHN JACKSON KENAI BLENDER; CHEUNG-LEE WAI LING; CHUN STEPHANIE W; HIRAGA KAORI; KOSJEK BIRGIT; KNIGHT JOHN H; MAKAREWICZ AMANDA M; MCCANN SCOTT; MOORE JEFFREY C; VERMA DEEPTAK
权利人:MERCK SHARP & DOHME LLC
摘要:The present disclosure provides ketoreductase enzymes having improved enzymatic properties including the capability of reducing hydroxy indanones to provide diastereomerically pure 1,3-indane diols useful for the synthesis of belzutifan. Also provided are polynucleotides encoding the ketoreductase enzymes, and host cells capable of expressing the ketoreductase enzymes. A purification procedure for isolating the ketoreductase enzymes is also provided.

专利号:US-2023286915-A1
优先权日:2020-10-07
标 题 :Synthesis of pyrrole acid derivatives
发明人：WILKINSON ANDREW; COOPER LAN; ORR DAVID; FINLAYSON JONATHAN; BUNT ADAM; KIRKHAM JAMES; LYTH DAVID; BLADES KEVIN
权利人:INFEX THERAPEUTICS LTD
摘要:This invention relates to the synthesis of compounds that can be used to treat bacterial infections in combination with other antibacterial agents, and more specifically in combination with a class of antibacterial agents known as carbapenems. The compounds resulting from the novel methods of the present invention are enzyme inhibitors and more particularly are metallo-β-lactamase inhibitors.

专利号:US-9255255-B2
优先权日:2013-03-04
标 题 :Synthesis of linear and branched polymers of polypeptides through direct conjugation
发明人：ALBAYRAK CEM; SWARTZ JAMES R; LU YUAN
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Methods are provided for a one step synthesis of polypeptide polymers or co-polymers. The polymers or co-polymers can be linear or branched. In the methods of the invention, the coding sequence for the polypeptide(s) to be polymerized is altered by introducing one or more codons for an nonnatural amino acid, which coding sequence is then utilized to produce the cognate polypeptide. The nonnatural amino acids are selected to be reactive with each other in a bioorthogonal reaction, and are combined in a conjugation reaction with the desired components of the polymer.

专利号:US-11311505-B2
优先权日:2017-02-24
标 题:Synergistic compositions to stimulate the synthesis of human lung and sinus surfactants to decrease coughing, increase FEV-1/FVC ratios, decrease lung fibrosis, by increasing apoptosis of myofibroblasts
发明人：MARTIN ALAIN
权利人:MARTIN ALAIN; CELLULAR SCIENCES INC
摘要:Methods for the treatment of patients with both Chronic Obstructive Pulmonary Disease (COPD) and pulmonary fibrosis, and of patients with idiopathic pulmonary fibrosis without COPD, by stimulating the synthesis of human and animal patient lung and sinus surfactants to increase lung functions, inhibiting fibrosis and reducing coughing and nasal erythema, include the following steps: A) analyzing and diagnosing a patient with a lung ailment selected from the group consisting of i) both COPD and pulmonary fibrosis; and ii) idiopathic pulmonary fibrosis without COPD; and, B) treating the patient to raise the patient's lung functions including FEV1/FVC ratio by contacting mammalian cells with a [therapeutically effective amount of a treatment] composition that includes: a) a pyruvate salt; b) a phosphate; c) a salt of calcium; and d) a salt of magnesium, in an aqueous carrier, containing no more than 2.2 grams of said pyruvate salt per liter.