CAS: 132938-37-5; 4-Chloro-6-Methyl-5-Prop-2-Ynylpyrimidin-2-Amine

上下游产品

CAS号81887-01-6 2-氨基-4-羟基-6-甲基-...

📜Ethyl 2-Acetylpent-4-Ynoate置于三氯氧磷体系中,用 甲醇,N,N-二甲基甲酰胺 用作溶剂,化学反应 22.0H,反应生成2-氨基-4-氯-6-甲基-5-炔丙基嘧啶
参考文献:2,4-Dichloro-5-(1-O-Carboranylmethyl)-6-Methylpyrimidine: A Potential Synthon For 5-(1-O-Carboranylmethyl)Pyrimidines
标题:2,4-Dichloro-5-(1-O-Carboranylmethyl)-6-Methylpyrimidine: A Potential Synthon For 5-(1-O-Carboranylmethyl)Pyrimidines
摘要:The Synthesis Of 2,4-Dichloro-5-(1-O-Carboranylmethyl)-6-Methylpyrimidine Is Described. Synthetically,This Novel O-Carboranyl Pyrimidine Is Approached From Ethyl 2-Acetyl-4-Pentynoate Through Alkylation Of Ethyl Acetoacetate With Propargyl Bromide And Subsequent Condensation With Thiourea To Yield 6-Methyl-5-(2-Propynyl)-2-Thio-4(1H,3H)-Pyrimidinone. Hydrolysis Of The 2-Thione And Chlorination With Pocl3 Gives 2,4-Dichloro-6-Methyl-5(2-Propynyl)Pyrimidine. Gentle Refluxing Of This Product With B10H14/ch3Cn In Toluene Yields The Target,2,4-Dichloro-5-(1-O-Carboranylmethyl)-6-Methylpyrimidine,A Potential Synthon For A Variety Of 2,4-Substituted 5-(1-O-Carboranylmethyl)-6-Methylpyrimidines And/or The Corresponding Nido-Undecaborates.
Doi:10.1021/jo00007A026