异丙醇胺 以87%的收率获得2,5-二甲基吡嗪 参考文献:Process For Preparing Pyrazines From Hydroxyamines 标题:Process For Preparing Pyrazines From Hydroxyamines 摘要:这项发明涉及羟基胺通过在催化剂存在下反应形成吡嗪的过程,该催化剂可以是含有碱土金属氧化物的过渡金属催化剂,或者催化剂可以是含有铑,钌或钯的化合物和含有磷化氢的化合物.
专利信息
专利号:US-6794512-B2 优先权日:2001-11-02 标 题:Efficient synthesis of 5-heteroatom-containing -pyrazoles 发明人:SHAVNYA ANDREI; SAYKA SUBAS M; MINICH MARTHA L; RAST BRYSON 权利人:PFIZER 摘要:An efficient synthesis of sulfonyl pyrazoles of formula I: n wherein the ring of the formula (R 5 )-A-(SO m R 4 ), m, R 1 through R 9 are as defined in the specification, comprising reacting a compound of formula II: n wherein the ring of the formula (R 5 )-A-(SO m R 4 ), m R 1 through R 9 are as defined above and wherein R 10 is halo, (C 1 -C 6 )alkyl-SO 3 —, (C 6 -C 10 )aryl-SO 3 —, (C 1 -C 6 )alkyl-SO 2 —, or (C 6 -C 10 )aryl-SO 2 —; wherein each of said (C 1 -C 6 )alkyl component of said (C 1 -C 6 )alkyl-SO 3 — and (C 1 -C 6 )alkyl-SO 2 — radicals may optionally be substituted on any carbon atom by one to six fluoro substituents per (C 1 -C 6 )alkyl component; with a compound of formula R 3 —H, wherein R 3 is as defined above, in the presence of a fluoride containing salt and in the presence of a solvent.
专利号:US-5091066-A 优先权日:1987-11-19 标 题 :Electrochemical synthesis of 2-methyl-5-pyrazinoic acid 发明人:FOA MARCO; FORLINI FABRIZIO; GATTI NORBERTO; BORSOTTI GIAMPIERO 权利人:MINI RICERCA SCIENT TECNOLOG 摘要:There is disclosed a process for the preparation of 2-methyl-5-pyrazinoic acid consisting of electrochemically oxidizing a compound having formula: ##STR1## wherein X is --OH, Cl, Br, --O--CO--R, --O--SO 2 --R, in which R is a C 1 -C 5 alkyl radical, optionally substituted with F or Cl, or it is a C 6 -C 12 aryl radical, in an aqueous alkaline medium, at a temperature ranging from 20° C. to 90° C., using anodes coated with nickel oxide-hydroxide.
专利号:US-3676442-A 优先权日:1968-11-22 标 题:Synthesis of pyrazines 发明人:BONZOM ALBERT; TRAMIER BERNARD 权利人:AQUITAINE PETROLE 摘要:Hydrocarbon substituted pyrazines are prepared by the reaction of an ammonium compound having NH4 or NH2 groups with an acetylene compound having an oxygen atom linked to the acetylenic unit, the reaction being conducted in an acid medium, preferably containing formic acid or a formate.
专利号:US-9676783-B2 优先权日:2008-10-22 标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds 发明人:HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN 权利人:ARRAY BIOPHARMA INC 摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
专利号:US-4469895-A 优先权日:1982-10-21 标题 :Process for preparing alcohols from olefins and synthesis gas 发明人:KNIFTON JOHN F; GRIGSBY JR ROBERT A 权利人:TEXACO INC 摘要:This invention concerns an improved process of preparing predominantly linear alcohols which comprises the steps of contacting a mixture of terminal and/or internal olefins and synthesis gas with a catalyst system comprising a ruthenium-containing compound in conjunction with one or more tertiary amine promoters, dispersed in a low melting quaternary phosphonium salt and heating said resultant reaction mixture under a pressure of 100 psi or greater at a temperature of at least 50 DEG C. for a sufficient time to produce said alcohols.
专利号:US-6010641-A 优先权日:1995-07-21 标题 :Liquid crystal polymer devices and materials 发明人:SAGE IAN C; BLACKWOOD KEITH M; VERRALL MARK A; COATES DAVID; BEATTIE DAVID R 权利人:SECR DEFENCE BRIT 摘要:Methods for loading and alignment of liquid crystal polymers in electro-optic and electro-active devices comprise in-situ polymerisation between substrates of monomer material in the presence of a cationic initiator. This allows for the synthesis of liquid crystal polymers containing polyether backbones.
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合成参考文献
摘要:Sheldon, R. A., Science of Synthesis: Water in Organic Synthesis, (2012) 1, 632. 摘要:Toxicology and Applied Pharmacology., 17(244), 1970 [] 摘要:S. F. Mason. J. Chem. Soc. 1959, 1247. 摘要:Das, A.; Ramkumar, N.; Veliks, J., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2. 参考文献:10.1093/chemse/bjj066 摘要:Thompson RN, Napier A, Wekesa KS. Attenuation of the production of inositol 1,4,5-trisphosphate in the mouse vomeronasal organ by antibodies against the alphaq/11 subfamily of G-proteins. Chem Senses. 2006 Sep;31(7):613–9. doi: 10.1093/chemse/bjj066.