CAS: 109-01-3; 1-Methylpiperazine

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34352-59-5 57260-70-5 57260-71-6

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CAS号111-42-2 二乙醇胺 | CAS号74-89-5 氨基甲烷 | CAS号325812-49-5 2-nitro-(N-meth... | CAS号110-85-0 哌嗪 | CAS号616-38-6 碳酸二甲酯 | CAS号16339-07-4 1-甲基-4-亚硝基哌嗪 | CAS号66739-87-5 1-甲基-4-(苯磺酰)哌嗪 | CAS号105-59-9 N-甲基二乙醇胺 | CAS号62226-74-8 1-甲基-4-(苯甲基)哌嗪 | CAS号105396-59-6 3'-Hydroxy-5'-(... | CAS号100491-52-9 6-氟-1-(4-氟苯基)-7... | CAS号108372-23-2 1-Piperazinepro... | CAS号104712-26-7 [4-methoxy-2-[4... | CAS号1053-74-3 2-Acetyl-10-[3-... | CAS号1059705-52-0 1-(3-氯-4-硝基苯基)-... | CAS号110358-10-6 1-Piperazinepro... | CAS号1093065-11-2 1-((3-溴-4-乙氧苯基)... | CAS号56323-03-6 1-(4-羟丁基)-4-甲基哌嗪 | CAS号55480-45-0 3-(4-甲基-1-哌嗪基)丙酸

1-甲基-4-亚硝基哌嗪置于pdmcm-41 Ammonium Formate体系中,用 甲醇 用作溶剂,化学反应 2.5H,以74%的收率获得n-甲基哌嗪
参考文献:在转移氢条件下,通过pdmcm-41催化剂选择性还原烯烃,α,β-不饱和羰基化合物,硝基芳烃,亚硝基化合物,偶氮和肼的n,N-氢解以及同时加氢脱卤和取代的芳基卤化物的还原
标题:在转移氢条件下,通过pdmcm-41催化剂选择性还原烯烃,α,β-不饱和羰基化合物,硝基芳烃,亚硝基化合物,偶氮和肼的n,N-氢解以及同时加氢脱卤和取代的芳基卤化物的还原
摘要:通过催化转移加氢实现烯烃,α,β-不饱和羰基化合物,硝基和亚硝基化合物的化学选择性还原,偶氮和肼基官能团的n,N-氢解以及同时还原和加氢脱卤化包括芳烃在内的卤代烷. (cth)使用中孔pdmcm-41催化剂.收率实际上不受催化剂再循环的影响.此外,在不影响任何其他可还原官能团的还原的情况下完成了cth过程.
Doi:10.1016/j.Tetlet.2004.02.098

专利信息

专利号:US-6252079-B1
优先权日:1993-06-30
标 题 :Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof
发明人：CURRAN DENNIS P; BOM DAVID
权利人:UNIV PITTSBURGH
摘要:The present invention provides a short, convergent total synthesis of irinotecan and derivative compounds which comprises of a novel 4+1 radical annulation wherein the precursoris reacted with an aryl isonitrile having the formulawherein X is Br or I, and R4 is an alkyl group, an allyl group, a propargyl group or a benzyl group, and R16 is H, a C1-C6 alkoxy group, agroup wherein p is an integer between 4 and 12, or a C1-C12 acyclic dialkylamino group. The present invention also provides novel chemical intermediates for such 4+1 radical annulations.

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:US-5521310-A
优先权日:1992-10-07
标 题 :Process to obtain benzoxazines to be used for the synthesis of ofloxazine, levofloxazine and derivatives
发明人：CARRETERO GONZALVEZ JUAN-CARLO; VICIOSO SANCHEZ MERCEDES; GARCIA RUANO JOSE-LUIS
权利人:ETILO DERIVADOS
摘要:A process to obtain benzoxazines useful for the synthesis of Ofloxazine, Levofloxazine and derivatives. The benzoxacines (I) where Xb is an halogen and R 1 is H, alkyl or alkenyl of up to 6 atoms of C or aryl, can be obtained by means of cycling a compound of formula (II) through the reaction with triphenylphosphine and ethyl azodicarboxilate. The compounds of formula (II) can be obtained through the reaction of a compound (III) with an adequate epoxide. Through the use of the adequate chiral epoxide it is possible to obtain the enantiomerically desired intermediate and, therefore and selectively, it is possible to obtain the desired final product with the adequate enantiomeric form without the need to carry out a resolution stage. n The Compounds (I) are useful and key intermediates for the synthesis of the antimicrobials Oflixazine and Levofloxazine. ##STR1##

专利号:US-8877930-B2
优先权日:2009-11-04
标 题 :Continuous flow synthesis of amino alcohols using microreactors
发明人：BEDORE MATTHEW W; ZABORENKO NIKOLAY; JENSEN KLAVS F; JAMISON TIMOTHY F
权利人:BEDORE MATTHEW W; ZABORENKO NIKOLAY; JENSEN KLAVS F; JAMISON TIMOTHY F; MASSACHUSETTS INST TECHNOLOGY
摘要:The present invention provides various methods for the synthesis of chemical species in a microreactor environment. In some cases, reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. For example, the method may involve the synthesis of amino alcohols within a microchannel. Embodiment described herein may allow for reactions with significantly shorter reaction times and increased efficiency.

专利号:US-9688644-B2
优先权日:2009-04-30
标 题 :Synthesis of Tetracyclines and intermediates thereto
发明人：MYERS ANDREW G; KUMMER DAVID A; LI DERUN; HECKER EVAN; DION AMELIE; WRIGHT PETER M
权利人:HARVARD COLLEGE
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for substituents at positions 4a, 5, 5a, and 12a of the tetracycline ring system.

专利号:US-11059914-B2
优先权日:2016-12-21
标题:Method for the continuous synthesis of a diene elastomer with lithium amide initiator
发明人：DIRE CHARLOTTE; DESSENDIER MARIE-HÉLÈNE
权利人:MICHELIN & CIE
摘要:A process for the continuous synthesis of a diene elastomer is provided. The synthesis is conducted by means of n reactors r1 to rn, considered to be continuous stirred-tank reactors, which are equipped with an internal stirring system. The reactors are arranged in series, n varying from 2 to 15, preferably from 2 to 9. The reactor r1 is fed by an input solution comprising a solvent, one or more monomer(s), an anionic polymerization initiator chosen from lithium amides and a polar agent. The conversion by weight C1 in the first reactor is less than 70%, and the total conversion by weight Cn at the outlet of the reactor rn is greater than or equal to 70%.