CAS: 93683-65-9; 6-Chloro-3-Nitropicolinonitrile

该化合物是一种多用途的热循环化合物,其核心为,硝基和西诺功能组.这种结构具有重要的回活动性,使它成为有机合成中的宝贵中间体,特别是制药和农用化学品.电排的硝基和西诺组增强了其在核生殖替代和循环反应中的效用.在标准条件下,其高纯度和稳定性确保了研究和工业应用的一贯性.该化合物定义明确的分子结构允许进行精确的修改,有利于开发具有特定特性的新衍生物.在受控实验室条件下使用,它需要根据其反应功能组采取适当的安全措施.

英文名称6-Chloro-3-Nitropicolinonitrile
中文名称6-氯-2-氰基-3-硝基吡啶
IUPAC名称6-chloro-3-nitropicolinonitrile
其它别名2-氰基-3-硝基-6-氯吡啶; 6-Chloro-3-Nitropyridine-2-Carbonitrile
CAS编号93683-65-9
MFCD编号:MFCD06657641
EINECS号:871-322-4
分子式:C6H2ClN3O2
分子量:183.55
产品CID: 1976712
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: XVIHGTRTKQZJAC-UHFFFAOYSA-N
InChI=1S/C6H2ClN3O2/c7-6-2-1-5(10(11)12)4(3-8)9-6/h1-2H…
计算化学: 氢键受体数4.0氢键供体数0.0可旋转键数1.0

相似化合物

95095-84-4 171178-21-5 1204400-58-7

MSDS等安全信息

GHS符号GHS07
危险类别急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险等级IRRITANT
UN编号UN2811
危险品标志T
安全声明H303+H313+H333

欧盟法规

C&L通报

上下游产品

合成工艺路线路线简述

16013-85-7 = 93683-65-9
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16013-85-7 = 93683-65-9
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16013-85-7 = 93683-65-9
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标题:Preparation Of Novel Pyridopyrimidine Derivatives As Pi3K Inhibitors
参考文献:United States]

16013-85-7 = 93683-65-9
反应条件:1.1 Solvents: N-Methyl-2-Pyrrolidone; Rt -> 180 °C; 2 H,180 °C
标题:4,6-Disubstituted Pyrido[3,2-D]Pyrimidine Compound,Its Preparation And Application In Preparation Of Mnk Inhibitor And Drug For Treating And/or Preventing Various Cancers And/or Metabolic Diseases
参考文献:China]

16013-85-7 = 93683-65-9
反应条件:1.1 Solvents: N-Methyl-2-Pyrrolidone; 180 °C
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作者:Han,Yu; Zhang,Huimin; Wang,Shuxiang; Li,Bo; Xing,Kun; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2021 卷标:64(18) 页码:13719-13735]

16013-85-7 = 93683-65-9
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16013-85-7 = 93683-65-9
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参考文献:China]

16013-85-7 = 93683-65-9
反应条件:1.1 Solvents: N-Methyl-2-Pyrrolidone; 15 Min,180 °C
标题:Development Of Substituted Pyrido[3,2-D]Pyrimidines As Potent And Selective Dihydrofolate Reductase Inhibitors For Pneumocystis Pneumonia Infection
作者:Shah,Khushbu; Queener,Sherry; Cody,Vivian; Pace,Jim; Gangjee,Aleem
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2019 卷标:29(15) 页码:1874-1880]

16013-85-7 = 93683-65-9
反应条件:1.1 15 Min,180 °C
标题:Monocyclic,Thieno,Pyrido,And Pyrrolo Pyrimidine Compounds And Methods Of Use And Manufacture Of The Same
参考文献:World Intellectual Property Organization]

16013-85-7 = 93683-65-9
反应条件:1.1 Solvents: N-Methyl-2-Pyrrolidone; 15 Min,6 Atm,180 °C
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16013-85-7 = 93683-65-9
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950778-43-5 = 93683-65-9
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作者:Piersanti,Giovanni; Giorgi,Luca; Bartoccini,Francesca; Tarzia,Giorgio; Minetti,Patrizia; Et Al
参考文献:Organic & Biomolecular Chemistry 日期:2007 卷标:5(16) 页码:2567-2571]

16013-85-7 = 93683-65-9
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16013-85-7 = 93683-65-9
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16013-85-7 = 93683-65-9
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16013-85-7 = 93683-65-9
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16013-85-7 = 93683-65-9
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参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2016 卷标:26(4) 页码:1224-1228

2,6-二氯吡啶置于n-甲基吡咯烷酮,硫酸,硝酸体系中,化学反应 6.0H,反应生成 6-氯-2-氰基-3-硝基吡啶
参考文献:Mnk1/2抑制剂4-(吲哚啉-1-基)-6-取代-吡啶并[3,2-D]嘧啶衍生物的设计,合成和生物学评价
标题:Mnk1/2抑制剂4-(吲哚啉-1-基)-6-取代-吡啶并[3,2-D]嘧啶衍生物的设计,合成和生物学评价
摘要:Mnk-Eif4E 轴在肿瘤发展中起着至关重要的作用,抑制 Mnk 激酶是一种有前景的癌症治疗方法.从片段开始,设计并合成了一系列4-(二氢吲哚-1-基)-6-取代-吡啶并[3,2-]嘧啶衍生物.在这些衍生物中,化合物对 Mnk1 和 Mnk2 显示出最高的效力,Ic 值分别为 0.8 和 1.5 Nm.此外,它在 30 种选定的激酶中表现出非常好的选择性.显着抑制 Molm-13 和 K562 细胞系生长并导致细胞周期停滞.此外,Western Blot 检测显示,有效下调下游蛋白-Eif4E,Mcl-1 和 C-Myc.此外,在大鼠血浆以及大鼠和人类微粒体中表现出显着的稳定性.抗肿瘤活性研究表明,在 Ll/2 同基因模型中,治疗可抑制肿瘤生长.这些发现凸显了 Mnks 作为新型有效抑制剂的潜力,值得进一步研究.
DOI:10.1016/j.Ejmech.2024.116499