CAS: 81148-15-4; 3-(4-(2-Hydroxy-3-(Isopropylamino)Propoxy)Phenyl)Propanoic Acid (Esmolol Impurity)

该化合物是埃斯莫洛的衍生物,是一种选择性乙1肾上抗体,主要用于临床环境中管理心血管炎和高血压.作为一种化学物质,埃斯莫洛酸的特征是其快速发作和短期作用,使其适合急性病情.由于其药用动力特性,通常静脉注射.化合物具有盒状酸功能组的特点,有助于其在水溶液中的溶解性.埃斯莫洛酸因其高度选择性而闻名于乙-1受体,最大限度地减少与乙-2受体阻塞相关的副作用.其结构包括乙基甲酸,该物质在体内进行水解以产生活性形态,埃索洛.埃莫洛酸的安全特征一般是可取的,但像所有药物一样,它可能与其他药物发生反常变,并可能与其他药物发生相互作用.

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esmolol hydr°Chloride 4-hydroxyphenylpropionic acid 3-(4-hydroxyphenyl)propionic acid methyl ester propionatemethyl 3-4-(2,3-epoxypropoxy)phenylpropionate phenyl>propionic acid hydr°Chloride3-4-2-hydroxy-3-(isopropylamino)propoxyphenylpropionic acid hydr°Chloride

合成工艺路线路线简述

  • 81161-17-3 = 81148-15-4
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol; 3 H,Rt -> Reflux
    标题:An Innovative Impurity Profiling Of Esmolol Hydrochloride Injection Using Uplc-Ms Based Multiple Mass Defect Filter,Chemometrics And In-Silico Toxicity Prediction
    作者:Zhang,Wei; Et Al
    参考文献:Arabian Journal Of Chemistry 日期:2023 卷标:16(4)]

    81147-94-6 + 75-31-0 = 81148-15-4
    反应条件:1.1 Solvents: Methanol; Reflux1.2 Reagents: Hydrochloric Acid Solvents: Diethyl Ether,Methanol2.1 Reagents: Tributyltin Oxide Solvents: Toluene; 48 H,Rt -> Reflux2.2 Solvents: Water; Reflux; 15 Min,Reflux
    标题:Hitting A Soft Drug With A Hard Nucleophile: Preparation Of Esmolol'S Metabolite By Treatment With Bis(Tributyltin) Oxide
    作者:Zhang,Cunyu A.; Et Al
    参考文献:Synthetic Communications 日期:2012 卷标:42(5) 页码:722-726]

    501-97-3 = 81148-15-4
    反应条件:1.1 Acidified,Reflux2.1 Reagents: Potassium Carbonate Solvents: Acetone; Reflux3.1 Solvents: Methanol; Reflux3.2 Reagents: Hydrochloric Acid Solvents: Diethyl Ether,Methanol4.1 Reagents: Tributyltin Oxide Solvents: Toluene; 48 H,Rt -> Reflux4.2 Solvents: Water; Reflux; 15 Min,Reflux
    标题:Hitting A Soft Drug With A Hard Nucleophile: Preparation Of Esmolol'S Metabolite By Treatment With Bis(Tributyltin) Oxide
    作者:Zhang,Cunyu A.; Et Al
    参考文献:Synthetic Communications 日期:2012 卷标:42(5) 页码:722-726]

    81161-17-3 = 81148-15-4
    反应条件:1.1 Reagents: Tributyltin Oxide Solvents: Toluene; 48 H,Rt -> Reflux1.2 Solvents: Water; Reflux; 15 Min,Reflux
    标题:Hitting A Soft Drug With A Hard Nucleophile: Preparation Of Esmolol'S Metabolite By Treatment With Bis(Tributyltin) Oxide
    作者:Zhang,Cunyu A.; Et Al
    参考文献:Synthetic Communications 日期:2012 卷标:42(5) 页码:722-726]

    5597-50-2 = 81148-15-4
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; Reflux2.1 Solvents: Methanol; Reflux2.2 Reagents: Hydrochloric Acid Solvents: Diethyl Ether,Methanol3.1 Reagents: Tributyltin Oxide Solvents: Toluene; 48 H,Rt -> Reflux3.2 Solvents: Water; Reflux; 15 Min,Reflux
    标题:Hitting A Soft Drug With A Hard Nucleophile: Preparation Of Esmolol'S Metabolite By Treatment With Bis(Tributyltin) Oxide
    作者:Zhang,Cunyu A.; Et Al
    参考文献:Synthetic Communications 日期:2012 卷标:42(5) 页码:722-726
📜盐酸艾司洛尔置于sodium Hydroxide体系中,化学反应 16.0H,反应生成 艾司洛尔酸
参考文献:超短效β-肾上腺素受体阻断剂.2.在芳基官能团上含有酯的(芳氧基)丙醇胺.
标题:超短效β-肾上腺素受体阻断剂.2.在芳基官能团上含有酯的(芳氧基)丙醇胺.
摘要:通过将酯官能团结合到某些(芳氧基)丙醇胺系统的芳基部分中,已经制备了几种短效β-肾上腺素能受体阻断剂.特别是,发现3-[4-[2-羟基-3-(异丙基氨基)丙氧基]苯基]丙酸甲酯盐酸盐(asl-8052)是一种中度有效的心脏选择性化合物,当在以下条件下测定时具有短的作用时间体内犬模型.
DOI:10.1021/jm00354A003

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参考文献:10.1021/jm00354a003
摘要:Erhardt PW, Woo CM, Anderson WG, Gorczynski RJ. Ultra-short-acting beta-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function. J Med Chem. 1982 Dec;25(12):1408–12. doi: 10.1021/jm00354a003.
参考文献:10.1097/00005344-198802000-00010|10.1097/00005344-198811020-00010
摘要:Shaffer JE, Quon CY, Gorczynski RJ. β-Adrenoreceptor Antagonist Potency and Pharmacodynamics of ASL-8123, the Primary Acid Metabolite of Esmolol. Journal of Cardiovascular Pharmacology. 1988 Feb;11(2):187–92. doi: 10.1097/00005344-198811020-00010.
参考文献:10.1016/s0003-4975(97)01420-3
摘要:Warters RD, Allen SJ, Davis KL, Geissler HJ, Bischoff I, Mutschler E, Mehlhorn U. Beta-blockade as an alternative to cardioplegic arrest during cardiopulmonary bypass. Ann Thorac Surg. 1998 Apr;65(4):961–6. doi: 10.1016/s0003-4975(97)01420-3.
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