CAS: 62409-13-6; 1-(3-Methoxyphenyl)Ethanamine

上下游产品

1-(3-methoxy-phenyl)-ethanone oxime 1-(3-Methoxyphenyl)ethanone N-formyl-1-(3-methoxyphenyl)ethylamine (R)-1-(3-methoxyphenyl)ethylamine N-[1-(3-Methoxy-phenyl)-ethyl]-oxalamic acid °Ctyl ester N-[1-(3-Methoxyphenyl)ethyl]phthalimide

📜3-甲氧基苯乙酮置于水,Formamide体系中,用 Neat (No Solvent) 作为反应溶剂,化学反应生成 1-(3-甲氧基苯基)乙胺
参考文献:苏氨酸氨基甲酸酯氨基甲酸酯衍生物的药效团模型设计,合成及抗真菌活性
标题:苏氨酸氨基甲酸酯氨基甲酸酯衍生物的药效团模型设计,合成及抗真菌活性
摘要:摘要 使用基于活性片段的药效团模型设计并合成了36种新型苏氨酸氨基甲酸酯氨基甲酸酯衍生物.在体外和体内测试了这些化合物对卵菌疫霉的抗真菌活性.有趣的是,化合物i-1,I-2,I-3,I-6和i-7在6.25μg/ Ml的温室中表现出对立方假单胞菌孢子的中等控制作用(> 50%),优于对照.同时,这些化合物中的大多数对辣椒衣原体具有明显的抑制作用.其他九种真菌也进行了测试.更重要的是,某些化合物对菌核菌,核果假单胞菌和茄形假单胞菌在体外的ec 50值为3.74-9.76μg/ Ml.该模型可能是可靠的,并且该方法可用于发现用于开发杀菌剂的先导化合物.
DOI:10.1080/14756366.2020.1729144

专利信息

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:US-8084630-B2
优先权日:2007-05-31
标 题 :Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL; TEVA PHARMA
摘要:The present invention provides processes and intermediates for the synthesis of ramelteon.

专利号:US-6653087-B1
优先权日:1997-02-07
标 题 :Convergent synthesis of combinatorial library
发明人：BOGER DALE L
权利人:SCRIPPS RESEARCH INST
摘要:Targeted C2-symmetric and unsymmetric chemical libraries for use in protein and receptor homodimerization and heterodimerization are constructed by solution phase methodologies. Exemplary libraries are prepared in a 60 to 10 sub-library format by symmetrical coupling of the constructed fragments with a mixture of tethering dicarboxylic acids. In each step of the 3-step reaction sequence, the reactants, unreacted starting material, reagents and their byproducts were removed by simple liquid-liquid or liquid-solid extractions providing the desired intermediates and final libraries in multi-milligram quantities in high purities (≧90-100%) independent of the reaction yields and without deliberate reaction optimization. The synthesis of a second prototypical library employed the olefin metathesis reaction to join and combinatorially randomize the length of linker tether. This approach provides a unique opportunity to rapidly generate a statistically controlled mixture of homo and heterodimers of remarkable diversity.

专利号:US-2009281176-A1
优先权日:2007-11-01
标题:Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
摘要:A process for the preparation of ramelteon and intermediates useful in the process. The process suitable for industrial scale provides increased yield and/or greater purity with fewer process steps.

专利号:US-5300437-A
优先权日:1989-06-22
标 题 :Enantiomeric enrichment and stereoselective synthesis of chiral amines
发明人：STIRLING DAVID I; MATCHAM GEORGE W; ZEITLIN ANDREW L
权利人:CELGENE CORP
摘要:Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process also can be used to stereoselectively synthesize one chiral form from ketones substantially to the exclusion of the other.

专利号:US-8932838-B2
优先权日:2010-06-17
标 题 :Biocatalysts and methods for the synthesis of (S)-3-(1-aminoethyl)-phenol
发明人：CABIROL FABIEN LOUIS; GOHEL ANUPAM; OH SEONG HO; SMITH DEREK J; WONG BRIAN; LALONDE JAMES J
权利人:CODEXIS INC
摘要:The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3′-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.