CAS: 6072-49-7; 2-(2-Thienyl)Benzoic Acid

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CAS号6165-68-0 2-噻吩硼酸 | CAS号88-65-3 邻溴苯甲酸 | CAS号610-94-6 2-溴苯甲酸甲酯 | CAS号610-97-9 邻碘苯甲酸甲酯 | CAS号615-36-1 2-溴苯胺 | CAS号124-38-9 二氧化碳 | CAS号106851-53-0 2-(2-溴苯基)噻吩 | CAS号188290-36-0 Thiophene(SIV) | CAS号1488-42-2 二苯基碘-2-羧酸内盐 | CAS号106183-47-5 2-diazonio-1-(2... | CAS号97677-81-1 2-(2-噻吩基)苯甲酰氯

📜2-(Methoxycarbonyl)Benzenediazonium Tetrafluoroborate置于potassium Acetate,Sodium Hydroxide体系中,用 乙醇,乙腈 作为反应溶剂,化学反应 28.0H,反应生成 2-噻吩基苯甲酸
参考文献:邻(5-甲酰基-2-噻吩基)苄腈和邻(5-甲酰基-2-呋喃基)苄腈的简单高效大规模无金属合成
标题:邻(5-甲酰基-2-噻吩基)苄腈和邻(5-甲酰基-2-呋喃基)苄腈的简单高效大规模无金属合成
摘要:含有联芳基序的有机分子构成了一类重要的有机化合物.许多是天然来源的,例如抗生素万古霉素.其他是治疗高血压的有价值的药物.一些含有联芳基的药物包括缬沙坦,氯沙坦,厄贝沙坦及其同系物.它们是当今处方最多的药物之一.在上个世纪,芳基-芳基键的形成一直是许多论文的主题,并且可以使用几种有效的联芳合成方法,例如 Ullmann,Suzuki-Miyaura 和 Negishi 反应.关于我们发现具有噻吩基-芳基和呋喃基-芳基结构特征的候选药物的开发项目,我们需要简单有效的方法来大规模合成 O-(5-Formyl-2-Thienyl) Benzonitrile 和 O-(5-Formyl-2Furyl)Benzonitrile.目前,报道的制备这些目标化合物或相应中间体邻-(2-噻吩基)苄腈和邻-(2-呋喃基)苄腈的方法采用来自各自有机锡试剂,锰催化氧化交叉的stille偶联.格氏试剂的偶联,钯催化的
DOI:10.1080/00304948.2018.1405334

专利信息

专利号:WO-9614277-A1
优先权日:1994-11-07
标 题:Synthesis of 35s-labeled oligonucleotides with 3h-1,2-benzodithiol-3-1,1-dioxide
发明人：IYER RADHAKRISHNAN P; AGRAWAL SUDHIR; TAN WEITIAN
权利人:HYBRIDON INC; IYER RADHAKRISHNAN P; AGRAWAL SUDHIR; TAN WEITIAN
摘要:This invention provides a novel compound for 35S-labelling oligonucleotides. The compound is 35S-3H-1,2-benzodithiol-3-one-1,1 dioxide (1). In Structure (I), the asterisk indicates the position of the 35S. Also provided is a method of synthesizing this compound, comprising first contacting 35S-thiobenzoic acid (4) with thiosalicylic acid (5) in acid medium to yield the condensation product, 35S-3H-1,2-benzodithiol-3-one (2). 35S-3H-1,2-benzodithiol-3-one (2) is then oxidized with a suitable oxidating agent such as trifluoroacetic acid and hydrogen peroxide to yield the desired product, 35S-3H-1,2-benzodithiol-3-one-1,1 dioxide (1). Any oligonucleotide susceptible to be oxidatively sulfurized by 3H-1,2-benzodithiol-3-one-1,1 dioxide can be labeled by 35S-3H-1,2-benzodithiol-3-one-1,1 dioxide (1). Accordingly, this invention also provides novel methods for 35S-labelling oligonucleotides. The compound and methods are useful for tracing biodistribution and degradation of antisense oligonucleotides in pharmacokinietic studies.

专利号:US-5833944-A
优先权日:1994-11-07
标题 :Procedure for the solid phase synthesis of 35 S-labeled oligonucleotides with 3H-1,2-benzodithiol-3-one-1,1-dioxide
发明人：IYER RADHAKRISHNAN P; AGRAWAL SUDHIR; TAN WEITIAN
权利人:HYBRIDON INC
摘要:This invention provides a novel compound for 35S-labelling oligonucleotides. The compound is 35S-3H-1,2-benzodithiol-3-one-1,1 dioxide (1) wherein the asterisk indicates the position of the 35S. Also provided is a method of synthesizing this compound, comprising first contacting 35S-thiobenzoic acid (4) with thiosalicylic acid (5) in acid medium to yield the condensation product, 35S-3 H 1,2-benzodithiol-3-one (2). 35S-3 H 1,2-benzodithiol-3-one (2) is then oxidized with a suitable oxidating agent such as trifuoroacetic acid and hydrogen perioxide to yield the desired product, 35S-3H-1,2-benzodithiol-3-one-1,1 dioxide (1). Any oligonucleotide susceptible to oxidative sulfurized by 3H-1,2-benzodithiol-3-one-1,1 dioxide can be labeled by 35S-3H-1,2-benzodithiol-3-one-1,1 dioxide (1). Accordingly, this invention also provides novel methods for 35S-labelling oligonucleotides. The compound and methods are useful for tracing biodistribution and degradation of antisense oligonucleotides in pharmacokinetic studies.

专利号:CN-1165508-A
优先权日:1994-11-07
标题:Synthesis of 35S-labeled Oligonucleotides Using 3H-1,2-Benzodithiol-3-1,1 Dioxide

专利号:EP-0790965-A1
优先权日:1994-11-07
标题 :Synthesis of ?35 s-labeled oligonucleotides with 3h-1,2-benzodithiol-3-1,1-dioxide

专利号:JP-H10509447-A
优先权日:1994-11-07
标 题 :<35> Synthesis of S-labeled oligonucleotide using 3H-1,2-benzodithiol-3-1,1-dioxide

专利号:AU-4101396-A
优先权日:1994-11-07
标 题 :Synthesis of 35s-labeled oligonucleotides with 3h-1,2-benzodithiol-3-1,1-dioxide