CAS: 57260-73-8; Tert-Butyl (2-Aminoethyl)Carbamate

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号107-15-3 乙二胺 | CAS号85363-04-8 2-(B°C-氨基)乙腈 | CAS号58632-95-4 2-(叔-丁氧基碳酰胺)-2-苯乙腈 | CAS号6627-89-0 叔丁基苯基碳酸酯 | CAS号4363-36-4 ethylendiamine | CAS号35150-09-5 B°C-甘氨酰胺 | CAS号77361-32-1 N-1-B°C-2-(1',3... | CAS号77153-05-0 N-cbz-N'-b°C-乙二胺 | CAS号34619-03-9 碳酸二叔丁酯 | CAS号1061318-65-7 2-(2-氯-3-硝基吡啶-4... | CAS号187339-13-5 2-(吡啶-2-基氨基)乙基氨... | CAS号215254-91-4 2-(N-异丁氧基甲酰胺基)乙烷基异氰 | CAS号222639-98-7 Tert-Butyl 2-(P... | CAS号225797-46-6 N-B°C-2-生物素酰氨基乙胺 | CAS号77153-05-0 N-cbz-N'-b°C-乙二胺 | CAS号117499-16-8 1,7-双-B°C-1,4,7... | CAS号134272-63-2 N-B°C-2-氨乙基马来酰亚胺 | CAS号122734-32-1 2-(甲基氨基)乙基氨基甲酸叔丁酯 | CAS号141743-15-9 Fm°C-N-(2-B°C-氨...

碳酸二叔丁酯置于乙二胺体系中,用 四氢呋喃,水 作为反应溶剂,化学反应生成 N-叔丁氧羰基-1,2-乙二胺
参考文献:Novel Cyclodextrin Dimers And Derivatives Thereof,Methods For Preparing Them And Their Use,In Particular,For The Solubilizing Pharmacologically Active Substances
标题:Novel Cyclodextrin Dimers And Derivatives Thereof,Methods For Preparing Them And Their Use,In Particular,For The Solubilizing Pharmacologically Active Substances
摘要:该发明涉及以下一般式(I)的化合物,其中:M代表一个等于5,6或7的整数;n和n1代表1到5之间的整数;a组代表特定的氢原子;x代表o或s;y代表特定的nr1基团,R1代表特定的氢原子;w代表ch或n;z代表特定的氢原子.

专利信息

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:WO-2004037772-A1
优先权日:2002-10-22
标 题 :Convenient and scalable synthesis of ethyl n-[(2-boc-amino) ethyl] glycinate and its hydrochloride salt
发明人：HUDSON ROBERT H E; VIIRRE RUSSELL D
权利人:UNIV WESTERN ONTARIO; HUDSON ROBERT H E; VIIRRE RUSSELL D
摘要:The present invention discloses an improved synthesis of ethyl N-[(2-Boc-amino)ethyl]glycinate and its hydrochloride salt. The synthesis is based on the reductive alkylation of Boc-ethylenediamine with ethyl glyoxylate hydrate and furnishes the title compound in near quantitative yield and high purity without chromatography. This compound is suitable, as is, for the synthesis peptide nucleic acid monomers. Further, conversion to the hydrochloride salt provides a stable, non-hygroscopic solid that is a convenient form for handling and storage.

专利号:US-2024082435-A1
优先权日:2021-02-26
标 题 :Solid phase synthesis of glutamate-urea-lysine derived (GUL derived) prostate-specific membrane antigen (PSMA) targeting conjugates and their use as precursors for therapeutic and/or diagnostic agents
发明人：PINTO ARTUR; BONTEMPS ALEXIS; LEMAIRE LUCAS
权利人:TELIX INT INNOVATIONS PTY LTD
摘要:The disclosure provides methods for the solid phase synthesis of glutamate-urea-lysine derived (GUL derived) prostate-specific membrane antigen (PSMA) targeting conjugates. The disclosure also relates to key intermediates of this process and methods for their preparation such as a method of preparing a compound of formula (V). Also disclosed are use of the conjugates as precursors for therapeutic and/or diagnostic agents, including treating and diagnosing prostate cancer.

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-2016257688-A1
优先权日:2013-10-24
标 题 :Process for Synthesis of Lactams
发明人：TAVARES FRANCIS XAVIER
权利人:TAVARES FRANCIS XAVIER
摘要:Methods for the synthesis of lactams are presented whereby a carboxylic acid of the formula HOOC—OR—NH-LG, wherein OR is an organic moiety and LG is a leaving group, is reacted with an acid, such as an organic acid, in particular a strong acid, and a dehydrating agent, which may be one in the same such as a strong acid anhydride, such that the amount of acid added allows for the desired transformation to take place without the loss of the leaving group (LG) before the cyclization, and recovering the lactam such as that of the formula (a), provided herein, wherein G represents the atom(s) needed to form a closed ring.

专利号:US-4515920-A
优先权日:1984-04-30
标题 :Synthesis of peptides and proteins
发明人：ERICKSON BRUCE W
权利人:UNIV ROCKEFELLER
摘要:Solid phase synthesis of peptides and proteins have been improved by the use of a trifunctional segment, one functional group of which is bound to a solid support, the other two functional groups being available as substrates upon which identical proteins are synthesized.