CAS: 54925-64-3; 1-(Tert-Butyldimethylsilyl)-1H-Imidazole

相似化合物

18156-74-6 37067-95-1 81452-04-2

上下游产品

1H-imidazole t-butyldimethylsilyl trichloroacetate tert-butyldimethylsilyl chloride silver(I) imidazolate4-acetyl-5'-O-(tert-butyldimethylsilyl)cytidineN4-acetyl-5'-O-(tert-butyldimethylsilyl)cytidine 2'-O-(tert-butyldimethylsilyl)-3'-(carboxymethyl)-3'-deoxy-5'-O-(4,4'-dimethoxytrilyl)adenosine (8S,10R)-8-(tert-butyldimethylsilyloxy)-10-phenylthio-1,4-dioxaspiro[4.5]dec-6-ene (3R,4S)-4-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-1-(4-iodophenyl)azetidin-2-one

叔丁基二甲基氯硅烷置于18-冠醚-6,Potassium Carbonate体系中,用 四氢呋喃 作为反应溶剂,化学反应 3.0H,反应生成 叔丁基二甲基哇烷基咪唑
参考文献:新型的基于三氯乙酰基的甲硅烷基化:叔丁基二甲基甲硅烷基化和保护氨基的简单方法.
标题:新型的基于三氯乙酰基的甲硅烷基化:叔丁基二甲基甲硅烷基化和保护氨基的简单方法.
摘要:已经开发出一种新的叔丁基二甲基甲硅烷基化试剂,并且已知的已知的三氯乙酸三甲基甲硅烷基酯(1)可用于n-甲硅烷基化胺.
DOI:10.1016/s0040-4039(00)85116-3

专利信息

专利号:US-5442065-A
优先权日:1993-09-09
标 题:Synthesis of tetrahydroquinoline enediyne core analogs of dynemicin
发明人：MAGNUS PHILIP D; ILIADIS THEODORE; EISENBEIS SHANE A; FAIRHURST ROBIN A
权利人:UNIV TEXAS
摘要:A process is described for the preparation of the core azobicyclo[7.3.1]tridecaenediyne moiety of the antitumor antibiotic dynemicin. The synthesis allows efficient production of the enediyne as a stable, compound in good yield from the adamantyl N-protected azabicyclo[7.3.1]tridecadiyne. The adamantyl protecting group is employed in the starting material, N-adamantyl dihydroquinoline or N-adamantyl 6-methoxy quinoline. Also disclosed are process for the synthesis of 3-hydroxy-6-methoxyquinoline and several N-substituted derivatives of azobicyclo[7.3.1]tridecaenediyne. Solid tumor and leukemia assays were performed on the analogs of dynemicin. The results suggest a method that these compounds will useful in treating certain types of leukemias and solid tumors. The disclosed synthesis provides a route to new dynemicin intermediates and analogs which will allow development of second and third generation dynemicins.

专利号:US-4354972-A
优先权日:1981-06-29
标 题 :Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:This invention relates to the synthesis of steroids which are useful for their biological activity or which may be converted to steroids which have such activity. These syntheses include the steroid compounds and processes for their preparation. n An object of the invention is to provide syntheses which are applicable to materials which are readily available in good supply for converting such materials to steroids which are useful and desirable in the manufacture of pharmaceutical products. n More particularly, I have sought to discover processes and intermediate compounds useful in the synthesis of 24, 25-dihydroxycholesterol from hyodeoxycholic acid or lithocholic acid which are constituents of, and readily available from, animal bile.

专利号:WO-2025104679-A1
优先权日:2023-11-16
标题 :Processes for making intermediates for isoindolinone inhibitors of the mdm2-p53 interaction having anticancer activity
发明人：SHAKYA SAGAR; JOHNSON MATT; WONG NICHOLAS; BODHURI PRABHUDAS; DAVAR NIPUN
权利人:OTSUKA PHARMA CO LTD
摘要:The present disclosure relates to processes for preparing synthetic intermediates for the synthesis of isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity.

专利号:US-8026349-B2
优先权日:2004-08-20
标题 :Polynucleotide synthesis labeling chemistry
发明人：HARTSEL STEPHANIE A; KAISER ROBERT J; DELANEY MICHAEL O
权利人:DHARMACON INC
摘要:Methods and compositions for making nucleoside phosphoramidites and nucleic acids, including mono-, di-, and polynucleotides, comprising a linker covalently attached to a levulinyl moiety are provided. A levulinyl-protected linking moiety affords an orthogonal approach to modifying a polynucleotide during or after solid phase synthesis with a molecule of interest, for example, a conjugate or a dye.

专利号:US-6004965-A
优先权日:1994-12-20
标题 :Sulfonamides
发明人：BREU VOLKER; BURRI KASPAR; CASSAL JEAN-MARIE; CLOZEL MARTINE; HIRTH GEORGES; LOEFFLER BERND-MICHAEL; MUELLER MARCEL; NEIDHART WERNER; RAMUZ HENRI
权利人:HOFFMANN LA ROCHE
摘要:Compounds of the formula: ##STR1## where A, B, R 1 -R 8 are as described herein are endothelin inhibitors that can be used in treating diseases associated with endothelin, such as high blood pressure. Chemical synthesis of these compounds and pharmaceutical compositions containing these compounds are also useful.

专利号:WO-2004046105-A2
优先权日:2002-11-15
标题 :Synthesis of 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids