CAS: 5455-98-1; 2-(Oxiran-2-Ylmethyl)Isoindoline-1,3-Dione

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CAS号1074-82-4 邻苯二甲酰亚胺钾盐 | CAS号3132-64-7 环氧溴丙烷 | CAS号106-89-8 环氧氯丙烷 | CAS号5428-09-1 N-烯丙基邻苯二甲酰亚胺 | CAS号556-52-5 缩水甘油 | CAS号19667-37-9 2-(3-氯-2-羟基丙基)异... | CAS号118712-54-2 oxiran-2-ylmeth... | CAS号446292-07-5 2-[(2R)-2-羟基-3-... | CAS号19667-37-9 2-(3-氯-2-羟基丙基)异... | CAS号112914-13-3 2-氨甲基-4-(4-氟苄基)吗啉 | CAS号35750-02-8 N-(3-氯-2-氧代丙基)苯... | CAS号616-29-5 1,3-二氨基-2-丙醇 | CAS号90503-16-5 2-(2-hydroxy-3-... | CAS号93272-45-8 1H-Isoindole-1,... | CAS号6284-26-0 1-溴-3-邻苯二甲酰亚氨基-2-丙烷酮 | CAS号6284-27-1 2-(3-bromo-2-hy... | CAS号6284-28-2 ethyl 5-[(1,3-d...

2-(3-氯-2-羟基丙基)异吲哚-1,3-二酮置于potassium Fluoride Supported On Celite体系中,用 乙腈 作为反应溶剂,化学反应 0.5H,以98%的收率获得产物n-(2,3-环氧丙基)邻苯二甲酰胺
参考文献:通过 Kf-Celite 介导的氨基卤代醇的闭环高区域选择性和高效合成氨基环氧化物
标题:通过 Kf-Celite 介导的氨基卤代醇的闭环高区域选择性和高效合成氨基环氧化物
摘要:几种氨基环氧化物的区域选择性合成已经在没有观测到任何痕量氮杂环丁烷醇的情况下实现,当氨基卤代醇用碱处理时,氮杂环丁醇通常被报道为唯一的反应产物.使用温和支持的碱 Kf-Celitein 回流乙腈对于调节观测到的优异区域选择性至关重要.
DOI:10.1055/s-0030-1260961

专利信息

专利号:US-2021220331-A1
优先权日:2016-05-03
标题:Inhibitors of ires-mediated protein synthesis
发明人：GERA JOSEPH F; LICHTENSTEIN ALAN; JUNG MICHAEL E; LEE JIHYE; HOLMES BRENT; BENAVIDES-SERRATO ANGELICA
权利人:UNIV CALIFORNIA; THE UNITED STATE GOVERNMENT REPRESENTED BY THE DEPT OF VETERANS AFFAIRS
摘要:This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers. This disclosure also relates to compositions comprising inhibitors of IRES-mediated protein synthesis and mTOR inhibitors, and to methods of treating cancer by conjoint administration of inhibitors of IRES-mediated protein synthesis and mTOR inhibitors.

专利号:US-8877171-B2
优先权日:2010-02-03
标 题 :Polyanionic multivalent macromolecules for intracellular targeting of proliferation and protein synthesis
发明人：LICHA KAI; SCHIRNER MICHAEL; WELKER PIA; HAAG RAINER; WEINHART MARIE; PAULUS FLORIAN
权利人:LICHA KAI; SCHIRNER MICHAEL; WELKER PIA; HAAG RAINER; WEINHART MARIE; PAULUS FLORIAN; MIVENION GMBH
摘要:The present invention relates generally to methods and compositions for targeting of intracellular molecules involved in proliferation and protein synthesis of activated cells using polyanionic multivalent macromolecules. In particular aspect, multiple sulfate groups linked to polyol are specifically targeted to the cytoplasm and nucleus of proliferating and activated cells. The invention further comprises novel polyanionic macromolecular compounds and formulations.

专利号:US-7038062-B2
优先权日:2004-07-01
标题:Synthesis of cyclic trithiocarbonates from epoxides
发明人：PARKER DANE KENTON
权利人:GOODYEAR TIRE & RUBBER
摘要:This invention provides a low cost technique for synthesizing cyclic trithiocarbonates by a simple one step process from epoxides that can be conducted under atmospheric pressure. This synthesis can be depicted as follows: n nwherein R represents a moiety selected from the group consisting of alkyl groups and aryl groups, wherein R′ represents a moiety selected from the group consisting of alkyl groups, aryl groups, and hydrogen atoms, and wherein R″ represents a moiety selected from the group consisting of alkyl groups, aryl groups, and hydrogen atoms, wherein the R moiety and the R′ moiety can be bonded together to form a cyclic structure, with the proviso that R″ represents a hydrogen atom if R′ represents an alkyl group or an aryl group. In this process carbon disulfide and a thiocyanate salt, such as potassium thiocyanate, are reacted with the epoxide in an ionic liquid, such as 1-butyl-3-methylimidazolium hexafluorophosphate ([Bmim] PF 6 ) in the presence of water to produce the cyclic trithiocarbonate.

专利号:WO-2013046211-A1
优先权日:2011-09-27
标 题 :Processes for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide and intermediates thereof
发明人：MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
权利人:SYMED LABS LTD; MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
摘要:TThe present invention provides processes for the preparation of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide (I) and intermediates thereof. Also provides novel intermediates and their use in the synthesis of oxazolidine derivatives.

专利号:WO-2006031179-A1
优先权日:2004-09-13
标 题:Process for preparation of phtalimide
发明人：KRIG ANN-SOFIE; THELIN MATS
权利人:ASTRAZENECA AB; KRIG ANN-SOFIE; THELIN MATS
摘要:The present invention is directed to a novel process for the synthesis of (S) -glycidyl phthalimide and to novel intermediates in the process. The process comprises, reacting a (R) -3 -Chloro-1,2-propanediol and phtalimide salt. Then reacting the product with trimethylorthoacetate and an essentially water free acid. Then reacting the product with acetyl halogenide and do a basic ester hydrolysis.

专利号:US-10385167-B2
优先权日:2015-02-13
标题:Process for the synthesis of polyoxazolidinone compounds with high stability
发明人：MÃœLLER THOMAS ERNST; Gürtler Christoph; BASU SUSMIT; RANGHEARD CLAUDINE; RIVILLO DAVID; LEITNER WALTER; Köhler Burkhard
权利人:COVESTRO DEUTSCHLAND AG
摘要:The present invention relates to polyoxazolidinone compounds, a method for the production of polyoxazolidinone compounds, comprising the step of reacting a biscarbamate compound with a bisepoxide compound in the presence of a mono-carbamate, a mono-isocyanate and/or a mono-epoxide compound as chain regulator and a suitable base having a pK b value of ≤9 as catalyst. The invention further relates to the use of polyoxazolidinone compounds with high thermal stability.