CAS: 52559-11-2; Pyridine-2,3,4-Triamine

该化合物是一种有机化合物,其特点是以2,3和4个位置的三组氨基氨基甲状腺环替换了松环,该化合物在水和极有机溶剂中溶于水和北极有机溶液中的无色和浅黄色固体,反映了其极性,反映了氨基亚氨基化合物的存在,它具有基本特性,典型的氨胺,可以参与各种化学反应,包括核生殖替代和金属离子的复合. 2,3,4-Triaminopriridine已引起人们对医药化学的兴趣,特别是其潜在的...

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相似化合物

24501-21-1 23244-87-3 452-58-4

上下游产品

CAS号24501-21-1 3-硝基吡啶-2,4-二胺 | CAS号626-03-9 2,4-二羟基吡啶 | CAS号5466-62-6 4,6-二羟基烟酸 | CAS号6975-44-6 4,6-二羟基烟酸乙酯 | CAS号89282-12-2 2,4-二羟基-3-硝基吡啶 | CAS号5975-12-2 2,4-二氯-3-硝基吡啶 | CAS号685542-71-6 3-Pyridinecarbo... | CAS号6317-97-1 4,6-二羟基-5-硝基吡啶-...

合成工艺路线路线简述

    4,6-二羟基烟酸乙酯置于sodium Sulfide,Sodium Hydroxide,氨,水,硝酸,溶剂黄146,三氯氧磷体系中,化学反应生成 2,3,4-三氨基吡啶
    参考文献:Koegl Et Al.,Recueil Des Travaux Chimiques Des Pays-Bas,1948,Vol. 67,P. 29,37
    标题:Koegl Et Al.,Recueil Des Travaux Chimiques Des Pays-Bas,1948,Vol. 67,P. 29,37

    海关参考信息

    专利信息


    专利号:US-8551996-B2
    优先权日:2009-02-20
    标题 :Compounds, compositions, methods of synthesis, and methods of treatment
    发明人:STEHOUWER JEFF; GOODMAN MARK; KILTS CLINT; NEMEROFF CHARLES
    权利人:STEHOUWER JEFF; GOODMAN MARK; KILTS CLINT; NEMEROFF CHARLES; UNIV EMORY
    摘要:Briefly described, embodiments of this disclosure include compounds as described herein, labeled compounds as described herein, pharmaceutical composition including compounds described herein, methods of imaging, method of forming a compound as described herein, and the like. In particular, embodiments of the disclosure include a series of triamino-pyridine derivatives and labeled triamino-pyridine derivatives, methods of synthesizing these compounds, intermediate compounds, methods of treatment using these compounds, methods of imaging, diagnosing, localizing, monitoring, and/or assessing a condition (e.g., corticotropin releasing factor type-1 (CRF1)) and/or related biological events, using triamino-pyridine derivatives, and the like. In addition, the present disclosure includes compositions (e.g., labeled triamino-pyridine derivatives that are ligands for the CRF1 receptor) used in and methods relating to non-invasive imaging (e.g., positron emission tomography (PET) imaging or SPECT imaging).

    专利号:US-7615634-B2
    优先权日:2003-02-10
    标题:4-aminopyrimidine-5-one derivatives
    发明人:BARTKOVITZ DAVID JOSEPH; CHU XIN-JIE; DING QINGJIE; JIANG NAN; LOVEY ALLEN JOHN; MOLITERNI JOHN ANTHONY; MULLIN JR JOHN GUILFOYLE; VU BINH THANH; WOVKULICH PETER MICHAEL
    权利人:HOFFMANN LA ROCHE
    摘要:Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.

    专利号:US-2011305636-A1
    优先权日:2009-02-20
    标题 :Compounds, compositions, methods of synthesis, and methods of treatment

    专利号:CA-2482705-A1
    优先权日:2002-04-17
    标题:Use of meglumine for inhibiting 3-deoxyglucosone synthesis in the skin

    专利号:US-2014179919-A1
    优先权日:2009-02-20
    标 题 :Compounds, compositions, methods of synthesis, and methods of treatment

    专利号:WO-2010096426-A8
    优先权日:2009-02-20
    标题 :Compounds, compositions, methods of synthesis, and methods of treatment
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    合成参考文献


    摘要:Sako, M., Science of Synthesis, (2004) 16, 1271.
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