CAS: 52500-61-5; 1-Amino-1-Phenylpropan-2-Ol
该化合物是配有分子式C9H13NO的手性氨基酒精化合物,其特征为氨基和氢氧基功能组,附于propan-2-ol骨干,在1位置上有一个苯替代物.这一结构使它成为有机合成的多种中间体,特别是用于制备药品,农用化学品和精美化学品.它的立体化学学允许在不对称合成中应用,它可以作为手性辅助或构件.该复合体在标准条件下的稳定性和与各种反应条件的兼容性进一步增强了其在研究和工业工艺中的实用性.
- 英文名称1-Amino-1-Phenylpropan-2-Ol
- 中文名称1-氨基-1-苯基丙-2-醇
- IUPAC名称1-amino-1-phenylpropan-2-ol
- 其它别名Beta-Amino-Alpha-Methyl-Benzeneethanol; B-Amino-A-Methylphenethyl Alcohol; 1-Amino-1-Phenyl-2-Propanol; 1-Phenyl-2-Hydroxypropylamine; Benzeneethanol, B-Amino-A-Methyl-
- CAS编号52500-61-5
- MFCD编号:MFCD11213424
- 分子式:C9H13NO分子量:151.21
- 产品CID: 2511692
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: AAEOXZIUGCXWTF-UHFFFAOYSA-N
- InChI=1S/C9H13NO/c1-7(11)9(10)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3
- 计算化学: 氢键受体数2.0氢键供体数2可旋转键数2
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1-Benzyloxyamino-1-Phenyl-Propan-2-Ol
合成工艺路线路线简述
- 合成目标产物 Beta-Amino-Alpha-Methyl-Benzeneethanol 主要起始原料 Benzeneethanol, β-(Dimethylamino)-α-Methyl-
- (文献来源)合成步骤主要原料 Benzeneethanol, β-(Dimethylamino)-α-Methyl-
📜苯基丙酮置于platinum(Iv) Oxide 亚硝酸特丁酯,氢气,Sodium Ethanolate体系中,用 甲醇,乙醇 作为反应溶剂,化学反应生成 Beta-氨基-Alpha-甲基-苯乙醇
参考文献:2-氨基5-芳基-2-恶唑酮.强大的新型阳极代理商.
标题:2-氨基5-芳基-2-恶唑酮.强大的新型阳极代理商.
摘要:
DOI:10.1021/jm00339A011
海关参考信息
- 2902600000-乙苯
2905122000-异丙醇
2922110001-单乙醇胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6107497-A
优先权日:1996-02-29
标题 :Intermediate for use in docetaxel synthesis and production method therefor
发明人：SISTI NICHOLAS J; SWINDELL CHARLES S; CHANDER MADHAVI C
权利人:NAPRO BIOTHERAPEUTICS INC; BRYN MAWR COLLEGE
摘要:C7, C10 di-CBZ 10-deacetyl baccatin III of the formula: ##STR1## provides an intermediate for the production of docetaxel. A method of producing this C7, C10 di-CBZ 10-deacetyl Baccatin III is provided. Here, 10-deacetyl Baccatin III is acylated with at least 1.5 equivalents of n-butyl lithium and at least 1.5 equivalents of benzyl chloroformate in tetrahydrofuran. The 10-deacetyl Baccatin III may first be dissolved in tetrahydrofuran after which the n-butyl lithium is added followed by the addition of the benzyl chloroformate. The reaction is preferably at a reduced temperature of less than -20° C. The resulting solution may be quenched with ammonium chloride and reduced to residue. The residue may then be redissolved in an organic solvent, washed, dried and recrystallized to purify the compound.
