CAS: 520-12-7; 5,7-Dihydroxy-6-Methoxy-2-(4-Methoxyphenyl)-4H-Chromen-4-One

该化合物是一种在各种植物中,包括硅菌和林里雅物种中发现的自然产生的氟氯素化合物,它展示了显著的生物活动,如抗炎,抗氧化剂和潜在的抗癌特性,使其成为药理学和营养学研究的一个主题,其行动机制包括调控NF-B和MAPK等信号路径,促进其治疗潜力. 甲草胺素还研究其肝脏保护和保护作用,在高纯度和稳定性的情况下,它作为分析化学的宝贵参考标准,是药物开发中的铅化合物. 它的多功能和功效突出其在生物医学应用中的重要性.

结构式图片

上下游产品

CAS号28978-02-1 大蓟苷 | CAS号77733-15-4 4',5,6-trimetho... | CAS号7499-99-2 1-(2,4-dihydrox... | CAS号794-94-5 4-甲氧基羟苯甲酸酐 | CAS号529-53-3 野黄芩素 | CAS号20032-42-2 2,5-dimethoxybe... | CAS号25892-94-8 1-(4-(benzyloxy...

合成工艺路线路线简述

  • 合成目标产物 Pectolinarigenin 主要起始原料 Pectolinarin
  • (文献来源)合成步骤主要原料 Pectolinarin
📜7-Benzyloxy-5,6-Dimethoxy-2-(4-Methoxy-Phenyl)-Chromen-4-One置于氢溴酸,溶剂黄146体系中,化学反应生成 柳穿鱼黄素
参考文献:Murti; Seshadri,Proceedings-Indian Academy Of Sciences,Section A,1949,# 30,P. 78,80
标题:Murti; Seshadri,Proceedings-Indian Academy Of Sciences,Section A,1949,# 30,P. 78,80

海关参考信息

专利信息


专利号:US-2002165207-A1
优先权日:2001-05-02
标题 :Compositions and methods for the treatment of diabetic neuropathy
发明人:ROSENBLOOM RICHARD
摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

专利号:US-7914823-B2
优先权日:2000-12-21
标题 :Method and composition for the topical treatment of diabetic neuropathy
发明人:ROSENBLOOM RICHARD ALLEN
权利人:PROPHASE LABS INC
摘要:A method and composition for the treatment of diabetic neuropathy is disclosed. The composition comprises a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant formulated in a pharmaceutically acceptable carrier. It has been found that this combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In view of the consensus in the art that effective combinations of various active agents have not been demonstrated to be effective for the treatment of diabetic neuropathy, the present invention provides a surprising and unexpected effect. In addition, the topical compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the topical administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is topically administered to the areas of the body that have been adversely affected by the diabetic neuropathy on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms and at least some recovery of the damaged nerve tissues.

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: Lim H, Son KH, Chang HW, Bae K, Kang SS, Kim HP. Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum. Biol Pharm Bull. 2008 Nov;31(11):2063-7.

合成参考文献


参考文献:10.1055/s-2005-873125
摘要:Luo Y, Zhou M, Qi H, Li B, Zhang G. Novel cadinane and norcadinane sesquiterpenes and a new propanoate from Goldfussia psilostachys. Planta Med. 2005 Nov;71(11):1081–4. doi: 10.1055/s-2005-873125.
参考文献:10.1021/np50001a002
摘要:Edwards JM, Raffauf RF, Le Quesne PW. Antineoplastic activity and cytotoxicity of flavones, isoflavones, and flavanones. J Nat Prod. 1979 Jan;42(1):85–91. doi: 10.1021/np50001a002.
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