📜2-乙基噻吩置于四氯化锡,一水合肼,苯体系中,化学反应生成 2,5-二乙基噻吩 参考文献:Steinkopf Et Al.,Justus Liebigs Annalen Der Chemie,1941,Vol. 546,P. 180,194 标题:Steinkopf Et Al.,Justus Liebigs Annalen Der Chemie,1941,Vol. 546,P. 180,194
专利号:US-2003064979-A1 优先权日:2001-06-29 标题 :Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48 发明人:HANSEN THOMAS KRUSE; OLSEN OLE HVILSTED; PETERSEN ANDERS KLARSKOV; LAU JESPER; ANDERSEN HENRIK SUNE; MOLLER NIELS PETER HUNDAHL 摘要:This invention relates to oxalylamide inhibitors of Protein Tyrosine Phosphatase 1B (PTP1B) and/or T-cell Protein Tyrosine Phosphatase (TC-PTP) and/or Protein Tyrosine Phosphatases (PTPases) having an aspartic acid (Asp) in position 48 (PTP1B numbering, Chernoff et al, Proc Natl Acad Sci USA 87: 2735-2789 (1989)) and a method of inhibiting such PTPases by exposing the enzyme to inhibitor compounds of formula 1 n n n This invention also relates to (I) the design and selection of inhibitors, which bind to the active site of PTP1B and/or TC-PTP and/or PTPases having an aspartic acid (Asp) in position 48 (II) the synthesis of said inhibitors, methods for their preparation and (III) to compositions comprising the inhibitor compounds.
专利号:US-9663594-B2 优先权日:2014-05-15 标 题 :Synthesis of aryl coupled bis phenoxides and their use in olefin polymerization catalyst systems with activator-supports 发明人:HLAVINKA MARK L 权利人:CHEVRON PHILLIPS CHEMICAL CO LP; CHEVRON PHILIPS CHEMICAL COMPANY LP 摘要:Disclosed herein are methods of making bis(phenol) ligand compounds and transition metal bis(phenolate) compounds. The transition metal bis(phenolate) compounds can be used as components in catalyst systems for the polymerization of olefins.
专利号:US-11332462-B2 优先权日:2012-02-08 标 题 :Heteroaryl compounds and methods of use thereof 发明人:CAMPBELL JOHN EMMERSON; CAMPBELL UNA; HANANIA TALEEN G; SHAO LIMING 权利人:SUNOVION PHARMACEUTICALS INC; PGI DRUG DISCOVERY LLC 摘要:Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
参考文献:10.1007/bf00953011 摘要:Ryashentseva MA, Minachev KM, Belanova EP, Bogdanov VS. Reactivity of C6-C8 alkanes in forming alkylthiophenes and aromatic hydrocarbons in the presence of H2S on a Cr-containing catalyst. Russian Chemical Bulletin. 1985 Dec;34(12):2489–92. doi: 10.1007/bf00953011. 参考文献:10.1007/pl00021990|10.1007/s10975-005-0013-z|10.1007/s10975-005-0050-7|10.1007/s10975-005-0051-6 摘要:Tsodikov MV, Kugel’ VY, Yandieva FA, Kliger GA, Glebov LS, Mikaya AI, Zaikin VG, Slivinskii EV, Plate NA, Gekhman AE, Moiseev II. Reductive dehydration of alcohols: A route to alkanes. Kinetics and Catalysis. 2004 Nov;45(6):854–66. doi: 10.1007/s10975-005-0013-z. 参考文献:10.1007/bf00903389 摘要:Danyushevskii YL, Marakatkina MA, Gol'dfarb YL. Synthesis in the furan series from organolithium compounds. Russian Chemical Bulletin. 1968 Nov;17(11):2397–404. doi: 10.1007/bf00903389. 参考文献:10.3103/s0361521917060076 摘要:Romadenkina SB, Sverchkov AA, Zemlyakov AY, Lobankov EV, Ilyasov VS. Chemical composition and physicochemical characteristics of shale tar from the Kotsebinskoe deposit. Solid Fuel Chemistry. 2017 Nov;51(6):355–7. doi: 10.3103/s0361521917060076. 参考文献:10.1007/bf00479935 摘要:Ryashentseva MA, Afanas'eva YA, Minachev KM. Catalytic methods for obtaining thiophene and alkylthiophenes from petroleum refining products and sulfur-containing organic compounds. Chemistry of Heterocyclic Compounds. 1971 Oct;7(10):1215–26. doi: 10.1007/bf00479935.