CAS: 489446-42-6; (4-(((Tert-Butoxycarbonyl)Amino)Methyl)Phenyl)Boronic Acid

英文名称(4-(((Tert-Butoxycarbonyl)Amino)Methyl)Phenyl)Boronic Acid
中文名称(4-(((叔丁氧羰基)氨基)甲基)苯基)硼酸
IUPAC名称(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)boronic acid
其它别名4-(Boc-氨甲基)苯硼酸
CAS编号489446-42-6
MFCD编号:MFCD04115637
EINECS号:846-010-6
分子式:C12H18BNO4
分子量:251.09
产品CID: 1479874
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: MUBGEKQUCSEECZ-UHFFFAOYSA-N
InChI=1S/C12H18BNO4/c1-12(2,3)18-11(15)14-8-9-4-6-10(7-5-9)13(16)17/h4-7,16-17H,8H2,1-3H3,(H,14,15)…
计算化学: 氢键受体数4.0氢键供体数3.0可旋转键数3.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi
风险等级Irritant/Keep Cold
安全声明26-36/37/39
危险类别码36/37/38
WGK Germany3

上下游产品

4-氨甲基苯硼酸 4-(Aminomethyl)Phenylboronic Acid 51239-46-4

合成工艺路线路线简述

合成目标产物 4-((N-Boc-Amino)Methyl)Phenylboronic Acid 主要起始原料 Tert-Butyl Carbamate
(文献来源)合成步骤主要原料 Tert-Butyl Carbamate

4-氨甲基苯硼酸反应生成 4-(Boc-氨甲基)苯硼酸
参考文献:Small Molecule Thienopyrimidine-Based Protein Tyrosine Kinase Inhibitors
标题:Small Molecule Thienopyrimidine-Based Protein Tyrosine Kinase Inhibitors
摘要:各种噻吩并嘧啶类衍生物能够选择性地抑制src家族的酪氨酸激酶.这些化合物在治疗包括过度增殖性疾病,血液病,骨质疏松症,神经性疾病,自身免疫病,过敏/免疫性疾病或病毒感染等多种疾病中是有用的.

海关参考信息

2902300000-甲苯
2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-11767302-B2
优先权日:2020-10-01
标题 :Reagents and methods for tetrazine synthesis
发明人：FOX JOSEPH M; LAMBERT WILLIAM; FANG YINZHI; AM ENDE CHRISTOPHER WILLIAM; MAHAPATRA SUBHAM; XIE YIXIN; WANG CHUANQI
权利人:UNIV DELAWARE
摘要:Disclosed herein are mono- and di-substituted tetrazines and methods of their preparation and converting an oxetanyl ester to a thio-substituted tetrazine, which is then converted to a mono-substituted tetrazine, a di-substituted tetrazine, or a vinylether disubstituted tetrazine.

专利号:US-9839642-B2
优先权日:2014-05-09
标题:Beta-tetrazolyl-propionic acids as metallo-beta-lactamase inhibitors
发明人：TANG HAIFENG; YANG SHU-WEI; MANDAL MIHIR; SU JING; LI GUOQING; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; PAN JIANPING; HAGMANN WILLIAM; DING FA-XIANG; XIAO LI; PASTERNAK ALEXANDER; HUANG YUHUA; DONG SHUZHI; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are metallo-Î²-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with Î²-lactam antibiotics for overcoming resistance.

专利号:US-9708336-B2
优先权日:2014-01-22
标题 :Metallo-beta-lactamase inhibitors
发明人：MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are metallo-Î²-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with Î²-lactam antibiotics for overcoming resistance.