CAS: 487-39-8; 4-((1S,3Ar,4R,6Ar)-4-(3,4-Dimethoxyphenyl)Tetrahydro-1H,3H-Furo[3,4-C]Furan-1-yl)-2-Methoxyphenol
该化合物是一个复杂的有机化合物,具有独特的结构特征,包含多种功能组,包括促进其化学反应和潜在生物活动的甲基氧和酚类.四氟铀的出现表明,由于其有其手感中心,它可能具有有趣的立体化学特性.这种化合物很可能在有机溶剂中溶解,其分子结构可能会与生物目标产生具体互动,使其对医药化学感兴趣.此外,甲氧基化合物的组可以增加脂性,从而有可能影响其药理学特性.
- 英文名称4-((1S,3Ar,4R,6Ar)-4-(3,4-Dimethoxyphenyl)Tetrahydro-1H,3H-Furo[3,4-C]Furan-1-yl)-2-Methoxyphenol
- 中文名称连翘脂素
- IUPAC名称4-((1S,3aR,4R,6aR)-4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl)-2-methoxyphenol
- 其它别名Philligenin; Phillygenin, >; 4-[(3S,3Ar,6R,6Ar)-6-(3,4-Dimethoxyphenyl)-1,3,3A,4,6,6A-Hexahydrofuro[3,4-C]Furan-3-Yl]-2-Methoxyphenol; (+)-Phillygenin; (1S)-1β-(3-Methoxy-4-Hydroxyphenyl)-4α-(3,4-Dimethoxyphenyl)-3Aβ,4,6,6Aβ-Tetrahydro-1H,3H-Furo[3,4-C]Furan; (1S,3Aβ,6Aβ)-1β-(3-Methoxy-4-Hydroxyphenyl)-4α-(3,4-Dimethoxyphenyl)Tetrahydro-1H,3H-Furo[3,4-C]Furan; 4-[[(1S)-4α-(3,4-Dimethoxyphenyl)-3Aβ,4,6,6Aβ-Tetrahydro-1H,3H-Furo[3,4-C]Furan]-1β-Yl]-2-Methoxyphenol; Phillygenin
- CAS编号487-39-8
- MFCD编号:MFCD01075148
- FDA UNII编号:886IAL08GN
- 分子式:C21H24O6分子量:372.42
- 产品CID: 1479052
- 产品分类生物化工 → 中草药成分
物理性质
- 熔点133 °C
- 沸点534.9±50.0 °C at 760 mmHg
- 闪点277.3±30.1 °C
- 密度1.2±0.1 g/cm3
- pKa:9.84±0.35(预测)
- PSA:66.38
- LogP:2.31
- 折射率1.570
- 蒸汽压0.0±1.5 mmHg at 25°C
- 溶解性DMF: 30 mg/mL; DMSO: 30 mg/mL; DMSO:Pbs (Ph 7.2) (1:5): 0.16 mg/mL
- 外观形态白色至类白色结晶性固体
- 储存条件2-8°C(避光保存)
- 产品应用该化合物用作内容确定,识别和药理实验;展示抗氧化活动,低脂性影响和低密度脂蛋白氧化抑制;显示体外强力抗糖瘤活动(比对鼠标B16黑皮瘤细胞的维辛基强);显示对DPPH和ABTS基的显著自由激进清扫活动,以及FRAP分析的强大减速能力.
MSDS等安全信息
上下游产品
phillyrin (3R,4S,5S,6R)-2-{4-[(1S,3aR,4S,6aR)-4-(3,4-Dimethoxy-phenyl)-tetrahydro-furo[3,4-c]furan-1-yl]-2-methoxy-phenoxy}-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol eudesmin eudesmine合成工艺路线路线简述
- 合成目标产物 (+)-Sylvatesmin 主要起始原料 Forsythin
- (文献来源)合成步骤主要原料 Forsythin
📜木須皮苷置于百里酚,Emulsin体系中,用 水 作为反应溶剂,化学反应 72.0H,以100 Mg的收率获得产物连翘脂素
参考文献:来自 Eremophila Spp. 的 Serrulatane 二萜.
标题:来自 Eremophila Spp. 的 Serrulatane 二萜.
摘要:摘要 九种新的 Serrulatane 二萜已从各种 Eremophila 物种中分离出来.提供了其结构的化学和光谱证据.
DOI:10.1016/s0031-9422(00)81293-5
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905399001-1,3-丙二醇
2905399002-1,4-丁二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2025049831-A1
优先权日:2021-12-01
标 题:Antiviral use of bisepoxylignan compound, and bisepoxylignan composition and preparation of bisepoxylignan compound
发明人：GE XIN; WANG SHUO; LU MINGMING; LIN RONGXIN; YANG ZIFENG; ZHONG NANSHAN; SUI DAYUN; YANG WEI; MA QINHAI; LU KESI
权利人:GE XIN
摘要:The present invention provides an application of a bisepoxylignan compound or a bisepoxylignan composition in prevention and treatment of infections with influenza viruses, parainfluenza viruses, COVID-19 viruses and COVID-19 virus variants, an application thereof in prevention and treatment of pulmonary hemorrhage caused by the COVID-19 viruses and the COVID-19 virus variants (e.g., Delta), an application thereof in anti-inflammatory effects on pneumonia caused by influenza viruses, parainfluenza viruses, COVID-19 viruses and COVID-19 virus variants. In addition, the present invention further provides a chemical synthesis method of a bisepoxylignan compound lianqiaoxinside.
专利号:CN-105461767-B
优先权日:2014-08-07
标题:A kind of chemical synthesis method of forsythin
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1002/pca.1194
摘要:Cui Y, Wang Q, Shi X, Zhang X, Sheng X, Zhang L. Simultaneous quantification of 14 bioactive constituents in Forsythia Suspensa by liquid chromatography–electrospray ionisation–mass spectrometry. Phytochemical Analysis. 2010 Apr 13;21(3):253–60. doi: 10.1002/pca.1194.
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