CAS: 459-46-1; 4-Fluorobenzyl Bromide

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CAS号459-56-3 对氟苯甲醇 | CAS号352-32-9 对氟甲苯 | CAS号459-57-4 对氟苯甲醛 | CAS号68162-47-0 4-溴甲基苯硼酸 | CAS号106-49-0 对甲苯胺 | CAS号352-11-4 对氟氯苄 | CAS号29180-23-2 p-fluorobenzyl ion | CAS号103-63-9 β-溴苯乙烷 | CAS号506-68-3 溴化氰 | CAS号370-21-8 (4-chloro-benzy... | CAS号111782-98-0 2-bromo-1-[(4-f... | CAS号347-91-1 2-(4-氟苯基)苯乙酮 | CAS号55096-88-3 N-苄基-4-氟苄基胺 | CAS号56442-17-2 4-(4-氟苯甲氧基)苯甲醛 | CAS号405-66-3 N-甲基-4-氟苄胺 | CAS号405-50-5 对氟苯乙酸 | CAS号459-04-1 4-氟苯乙酰氯 | CAS号459-56-3 对氟苯甲醇 | CAS号456-22-4 对氟苯甲酸 | CAS号459-22-3 4-氟氰苄

对氟甲苯置于n-溴代丁二酰亚胺(Nbs),过氧化苯甲酰体系中,用 四氯化碳 作为反应溶剂,化学反应生成 4-氟溴苄
参考文献:苯并[c]菲的高效氟促进分子内缩合:直接合成富勒烯的新前景
标题:苯并[c]菲的高效氟促进分子内缩合:直接合成富勒烯的新前景
摘要:已经测试了各种官能团作为苯并 [c] 菲在快速真空热解条件下分子内缩合的替代促进剂.发现甲基和氟官能化是有前途的方法.在氟化苯并[c]菲的环化中观测到了出乎意料的高选择性.讨论了缩合反应的机理和氟作为促进富勒烯合理合成的促进剂的优势. (© Wiley-Vch Verlag Gmbh & Co. Kgaa,69451 Weinheim,Germany,2009)
DOI:10.1002/ejoc.200900976

专利信息

专利号:US-2025026768-A1
优先权日:2023-06-30
标题:Method for the synthesis of axially chiral organoboron compounds
发明人：PING YIFAN; CHE CHI-MING
权利人:LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
摘要:A highly efficient and atroposelective Rh-catalyzed [2+2+2] cycloaddition for the synthesis of axially chiral aryboron compounds is developed. The reactions of diynes and alkynylborons smoothly occur in an atom-economical manner, affording a variety of C—B atropisomers in excellent yields and enantioselectivities. The protocol features mild conditions, broad substrate scope, and good functional tolerance. The obtained C—B atropisomers show powerful synthetic applications in terms of producing novel chiral phosphine ligands.

专利号:US-5554753-A
优先权日:1993-08-25
标 题:Catalytic enantioselective synthesis of α-amino acid derivatives by phase-transfer catalysis
发明人：O'DONNELL MARTIN J; WU SHENGDE; ESIKOVA IRENA; MI AIQIAO
权利人:INDIANA UNIVERSITY FOUNDATION
摘要:Described are improved processes for the enantioselective synthesis of α-amino acids which involve combinations of solvents, highly-mixed and low-temperature reaction conditions, and novel catalysts. Also described are novel catalysts and precursors to α-amino acid derivatives.

专利号:US-5468876-A
优先权日:1986-05-22
标题:Intermediates for the stereoconservative synthesis of 1-substituted (S)-and (R)-2-aminomethylpyrrolidines
发明人：FEDERSEL HANS-JUEGEN; HOE THOMAS; RAEMSBY STEN I; STROEM PETER H E
权利人:ASTRA AB
摘要:Disclosed are (R)- and (S)-isomers of the compounds of the Formulas II and III with at least 95% optical purity ##STR1## wherein R 1 and R 2 are the same or different and represent a hydrogen atom, a lower alkyl, lower alkenyl or lower alkynyl group, a cycloalkyl group or a group (CH 2 ) m Ph, wherein m is 0-3 and Ph is a substituted or unsubstituted phenyl group. n These compounds are intermediates in the stereoconservative synthesis of 1-substituted (S)- and (R)-2-aminomethylpyrrolidines.

专利号:US-6867202-B1
优先权日:1997-06-25
标 题 :Treatment of insulin resistance
发明人：CARPINO PHILIP ALBERT; CHIU CHARLES KWOK-FUNG; PAN LYDIA CODETTA; LEFKER BRUCE ALLEN; TREADWAY JUDITH LEE; ZAWISTOSKI MICHAEL PAUL
权利人:PFIZER
摘要:This invention is directed to methods of treating insulin resistance in a mammal which comprise administering an effective amount of a compound of formula I, n n nwhere the variables are defined in the specification, or the stereoisomeric mixtures, diastereomerically enriched, diastereomerically pure, enantiomerically enriched or enantiomerically pure isomers, or the pharmaceutically acceptable salts and prodrugs thereof to said mammal. The compounds of formula I are growth hormone secretagogues and as such are useful for increasing the level of endogenous growth hormone. In another aspect this invention provides certain intermediates which are useful in the synthesis of the foregoing compounds and certain processes useful for the synthesis of said intermediates and th compounds of formula I. This invention is further directed to methods comprising administering to a human or other animal a combination of a functional somatostatin antagonist such as an alpha-2 adrenergic agonist and a compound of formula I.

专利号:US-4613610-A
优先权日:1984-06-22
标题 :Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
发明人：WAREING JAMES R
权利人:SANDOZ PHARMACEUTICALS CORP
摘要:Compounds of the formula wherein R1 is C1-6alkyl not containing an asymmetric carbon atom, each of R2 and R5 is independently hydrogen, C1-3alkyl, n-butyl, i-butyl, t-butyl, C1-3alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenyl, phenoxy or benzyloxy, each of R3 and R6 is independently hydrogen, C1-3alkyl, C1-3alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, each of R4 and R7 is independently hydrogen, C1-2alkyl, C1-2alkoxy, fluoro or chloro, with the provisos that not more than one of R2 and R3 is trifluoromethyl, not more than one of R2 and R3 is phenoxy, not more than one of R2 and R3 is benzyloxy, not more than one of R5 and R6 is trifluoromethyl, not more than one of R5 and R6 is phenoxy, and not more than one of R5 and R6 is benzyloxy, X is -(CH2)m-, -CH=CH-, -CH=CH-CH2- or -CH2-CH=CH-, wherein m is 0, 1, 2 or 3, and Z is wherein R10 is hydrogen or C1-3alkyl, wherein R12 is a physiologically acceptable and hydrolyzable ester group, and M is a pharmaceutically acceptable cation, with the provisos that (i) the-X-Z group is in the 4- or 5-position of the pyrazole ring, and (ii) the R1 group and the -X-Z group are ortho to each other, the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.

专利号:US-9364482-B2
优先权日:2013-06-24
标 题 :Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
发明人：DAI XING; LIU HONG; PALANI ANANDAN; HE SHUWEN; NARGUND RAVI; XIAO DONG; ZORN NICOLAS; DANG QUN; MCCOMAS CASEY C; PENG XUANJIA; LI PENG; SOLL RICHARD
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system. (I)