CAS: 4163-15-9; Cyclorphan

上下游产品

左啡诺 Levorphanol 77-07-6
左美沙芬 Levomethorphan 125-70-2
羟啡烷 Rac-Morphinan-3-Ol 1531-12-0
3-甲氧基吗喃盐酸盐 (-)-3-Methoxymorphinan 1531-25-5
17-Ethoxycarbonyl-3-Hydroxy-Morphinan 58434-39-2

📜左啡诺置于lithium Aluminium Tetrahydride,1-氯乙基氯甲酸酯,氢溴酸,溶剂黄146,三乙胺体系中,化学反应生成 17-(环丙基甲基)吗喃-3-醇
参考文献:Kappa阿片类激动剂可卡因滥用中的药物治疗靶标.
标题:Kappa阿片类激动剂可卡因滥用中的药物治疗靶标.
摘要:Kappa阿片受体的名称源自原型苯并吗啡酮环唑啉(1A),其产生的行为效应不同于吗啡的行为效应,但被阿片拮抗剂纳曲酮拮抗.最近的证据表明,K阿片受体的激动剂和拮抗剂可能调节多巴胺能神经元的活性并改变可卡因的神经化学和行为作用.在可卡因歧视和有计划控制的反应研究中,Kappa激动剂阻断了可卡因在松鼠猴中的作用.在恒河猴中的研究表明,阿片类药物可能拮抗可卡因的增强作用.这些研究促使合成和评估了一系列与吗啡喃,L-Cyclorphan(3A)和苯并吗啡有关的K激动剂,L-环唑啉(2).我们描述了一系列吗啡喃的合成和初步评估,吗啡环糊精3A-C,10-酮吗啡喃4A和b,8-酮苯并吗啡喃1B的结构类似物,其结构与酮环唑啉(1A)有关.在结合实验中,L-Cyclorphan(3A),环丁基(3B),四氢糠基3C和10-酮4B类似物对mu(mu),Delta(delta)和kappa(kappa)阿片受
DOI:10.1016/s0031-6865(99)00044-8

专利信息

专利号:US-10022366-B2
优先权日:2013-04-23
标 题:Extending and maintaining micropore viability of microneedle treated skin with lipid biosynthesis inhibitors for sustained drug delivery
发明人：STINCHCOMB AUDRA L; GHOSH PRIYANKA
权利人:STINCHCOMB AUDRA L; GHOSH PRIYANKA; UNIV MARYLAND; UNIV KENTUCKY RES FOUND
摘要:Microneedles and their use as a physical skin permeation enhancement technique facilitate drug delivery across the skin in therapeutically relevant concentrations. Micropores created in the skin by MNs reseal because of normal healing processes of the skin, thus limiting the duration of the drug delivery window. Pore lifetime enhancement strategies can increase effectiveness of MNs as a drug delivery mechanism by prolonging the delivery window. Fluvastatin (FLU) was used to enhance pore lifetime by inhibiting the synthesis of cholesterol, a major component of the stratum corneum lipids. The skin recovered within a 30-45-min time period following the removal of occlusion, and there was no significant irritation observed due to the treatment compared to the control sites. Thus, it can be concluded that localized skin treatment with FLU can be used to extend micropore lifetime and deliver drugs for up to 7 days across MN-treated skin.

专利号:US-5900227-A
优先权日:1996-06-17
标题 :Multicyclic nitrone spin trapping compositions
发明人：JANZEN EDWARD G; SANKURATRI NAGARAJU
权利人:OKLAHOMA MED RES FOUND
摘要:Multicyclic nitrone spin trapping compounds capable of forming stable free radical spin adducts are provided as well as methods for their synthesis. The multicyclic nitrone spin trapping compounds can be reacted with a free radical, such as a hydroxy or hydroperoxy radical, in solution to form a spin adduct which is stable and readily detectable by electron paramagnetic resonance (EPR) spectroscopy. The multicyclic nitrone spin traps can be used to detect free radicals in a sample such as a biological system. In one embodiment, the spin trapping compound, 1,3,3-trimethyl-6-azabicyclo-[3.2.1]oct-6-ene-N-oxide ('TRAZON') is provided, as well as methods for the synthesis of TRAZON and of modified forms of TRAZON. TRAZON can react with a wide range of different free radicals in solution to form free radical spin adducts which are readily detectable by EPR.

专利号:US-7632519-B2
优先权日:2005-04-25
标 题:TRPV1 agonist compounds, formulations, prodrugs, methods for using the same
发明人：JAMIESON GENE CURTIS; MUHAMMAD NAWEED; BLEY KEITH R
权利人:NEUROGESX INC
摘要:Described here are TRPV1 agonist compounds and their methods of synthesis and use. In addition to specifically identified compounds, capsaicin prodrugs, gemini dimers, and mutual prodrugs are also described. Formulations of the TRPV1 agonist compounds may be in the form of a liquid, tablets, capsules, gel, cream, emulsion, a patch, or the like. Methods for treating medical conditions using the compounds, compositions, or prodrugs described, are also provided.