CAS: 367-22-6; 4-Chloro-3-Fluoroaniline

该化合物是一种芳香的汞,其特征是苯环上存在氯和氟替代物,该化合物具有一种主要安咪功能组(-NH2),该组与苯相连,影响其再活性和溶性,在室内温度上一般是固体,在有机溶剂中可溶解,其溶解性因缺水芳烃结构而有限,水中的溶性有限.电子内氯和氟原子的存在可影响化合物的电子特性,使其在有机合成中成为有用的中间体,特别是在制药和农用化学品生产中.此外,4-Chrloro-3-氟苯胺可能展示生物活动,可在各种化学和医药应用中加以探讨.在处理这一化合物时应采取安全防范措施,因为其可能对健康造成危害,包括皮肤和呼吸刺激.适当的储存和处置方法对于减轻环境影响至关重要.

英文名称4-Chloro-3-Fluoroaniline
中文名称4-氯-3-氟苯胺
IUPAC名称4-chloro-3-fluoroaniline
其它别名4-Chloro-3-fluoro-phenylamine; 3-Fluoro-4-chloroaniline
CAS编号367-22-6
MFCD编号:MFCD01090987
EINECS号:206-683-3
FDA UNII编号:5B8GP7SE8E
分子式:C6H5ClFN
分子量:145.56
产品CID: 1376384
产品分类有机原料 → 有机氟化合物 → 氟苯胺系列

相似结构搜索
InChIKey: ACMJJQYSPUPMPN-UHFFFAOYSA-N
InChI=1S/C6H5ClFN/c7-5-2-1-4(9)3-6(5)8/h1-3H,9H2…
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数0.0

MSDS等安全信息

GHS象形图
GHS符号GHS06;
注释: Skull and crossbones
危险类别急性毒性类别3(吸入)
急性毒性类别3(经皮)
急性毒性类别4(经口)
严重眼损伤类别1
水生慢性毒性类别3
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别3(经口)
急性毒性类别4(吸入)
急性毒性类别4(经皮)
严重眼刺激类别2A
特定目标器官毒性-重复接触类别2
警示词Danger(危险)
危险描述H331 |吸入会中毒.
H311 |皮肤接触会中毒.
H302 |吞咽有害.
H318 |造成严重眼损伤.
H412 |对水生生物有害并具有长期持续影响.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H301 |吞咽会中毒.
H332 |吸入有害.
H312 |皮肤接触有害.
H373 |长期或反复接触可能损害器官.
防范说明P261-P280-P301+P312-P302+P352+P312-P304+P340+P311-P305+P351+P338
危险等级6.1
UN编号UN2811
危险品标志T,Xi
风险等级Toxic
包装等级III
安全声明26-36/37/39-63-45-38
危险类别码20/21/22-36/37/38
WGK Germany3

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

(4-氯-3-氟苯基)氨基甲酸叔丁酯置于一氯化碘,溶剂黄146体系中,化学反应生成 4-氯-3-氟苯胺
参考文献:Robust Synthesis Of Methyl 5-Chloro-4-Fluoro-1H-Indole-2-Carboxylate: A Key Intermediate In The Preparation Of An Hiv Nnrti Candidate
标题:Robust Synthesis Of Methyl 5-Chloro-4-Fluoro-1H-Indole-2-Carboxylate: A Key Intermediate In The Preparation Of An Hiv Nnrti Candidate
摘要:A Synthetic Preparation Of Methyl 5-Chloro-4-Fluoro-1H-Indole-2-Carboxylate,A Key Intermediate Towards Phosphoindole Inhibitors Of Hiv Non-Nucleoside Reverse Transcriptase,Is Described. The Five-Step Synthesis Involved Boc Protection Of The Commercially Available 4-Chloro-3-Fluoroaniline And Regioselective Iodination At C-2. After Facile Boc Deprotection,Cyclization Of The Resultant O-Iodoaniline Gave The Corresponding 5-Chloro-4-Fluoro-Indole-2-Carboxylic Acid Which Was Subsequently Esteritied To Provide The Target Indole Ester In 56% Overall Yield. Identification Of 6-Chloro-7-Iodo-2(3H)-Benzoxazolone As A Significant Side Product In The Iodination Step Led To The Development Of Conditions Which Eliminated Its Formation In Subsequent Batches. Advantages Of This Alternative Approach Relative To Existing Methodologies Include (1) Potentially Hazardous Diazonium And Azido Species Were Not Required,(2) Regioisomeric Products Were Not Generated,And (3) Chromatographic Isolations Were Avoided,As All Intermediates Were Easily Crystallized. As A Result,The Key Indole Ester Was Produced Rapidly At 100-Fold Increased Scale Compared To Previous Reports With A 10-Fold Improvement In Overall Yield.
DOI:10.1021/op1001808

海关参考信息

2903919090-氯苯
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详情请参考：📖 海关编码查询和海关进出口税则

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