CAS: 34450-18-5; 17-Odya

该化合物是一种长链脂肪酸,其特点是碳氢化合物链中第17和第18个碳原子之间存在三联体.这种不饱和脂肪酸是乙酰脂肪酸组的一部分,因其独特的结构,影响其化学反应和物理特性而值得注意.它通常在室温中是一种固体,在水中溶解,但在有机溶剂中可溶解.三联体的存在具有不同的特点,例如与饱和脂肪酸相比,反应性增加,使其在各种化学合成和有机化学应用中有用.此外,17-ocdecynoic酸可以作为其他生物活性化合物合成的前体,并有可能用于材料科学和生物化学化学数据库和监管环境中的识别.

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CAS号87640-08-2 °Ctadec-17-yn-1-ol | CAS号52056-69-6 2-(11-bromounde... | CAS号1611-56-9 11-溴十一醇 | CAS号2861-49-6 °Ctadec-9-yn-1-ol | CAS号112-80-1 油酸 | CAS号112-62-9 油酸甲酯 | CAS号506-13-8 16-羟基十六烷酸 | CAS号1120-32-7 9-炔十八酸甲酯 | CAS号25456-04-6 METHYL 9,10-DIB... | CAS号2380-32-7 17-Ketostearic ... | CAS号87640-10-6 methyl 18-iodoo...

合成工艺路线路线简述

    📜油酸甲酯置于chromium(Vi) Oxide,Lithium Aluminium Tetrahydride,硫酸,溴,Potassium Hydride,1,8-二氮杂双环[5.4.0]十一碳-7-烯,1,3-丙二胺体系中,用 乙醚,氯仿,丙酮 用作溶剂,化学反应 35.5H,反应生成17-十八炔酸
    参考文献:Synthesis And Evaluation Of Radioiodinated (E)-18-Iodo-17-octadecenoic Acid As A Model Iodoalkenyl Fatty Acid For Myocardial Imaging
    标题:Synthesis And Evaluation Of Radioiodinated (E)-18-Iodo-17-octadecenoic Acid As A Model Iodoalkenyl Fatty Acid For Myocardial Imaging
    摘要:125I-Labeled (E)-18-Iodo-17-octadecenoic Acid (13) Has Been Prepared And Evaluated In Rats To Determine The Myocardial Uptake And Retention And Degree Of In Vivo Deiodination Of This Model Iodovinyl-Substituted Fatty Acid,Which Contains No Structural Perturbation To Inhibit Metabolism. This New Agent Was Prepared By Nai-Chloramine-T Treatment Of (17-Carbomethoxyheptadec-1-En-1-yl)Boronic Acid (11) Prepared By Catecholborane Treatment Of Methyl 17-octadecynoate (10),Followed By Basic Hydrolysis To The Free Acid (13). The Pivotal Substrate,17-octadecynoic Acid (9),Was Prepared By Two New Routes. The 125I-Labeled Acid 13 Showed High Myocardial Uptake (1 H,1.90-2.28% Dose/g) With 45% Washout After 2 H But Lower Heart/blood Ratios In Comparison To Analogues Containing The Tellurium Heteroatom. Deiodination Was Low For The First 2 H After Injection (2 H,61% Dose/g). Excellent Myocardial Images Were Obtained In A Dog With The 123I-Labeled Agent.
    Doi:10.1021/jm00367A021

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    专利信息


    专利号:US-11708320-B2
    优先权日:2018-06-29
    标 题:Environmentally-friendly hydroazidation of olefins
    发明人：XU HAO
    权利人:UNIV GEORGIA STATE RES FOUND
    摘要:The present invention provides processes for the synthesis of organic azides, intermediates for the production thereof, and compositions related thereto.

    专利号:US-8415400-B2
    优先权日:2003-05-16
    标题:Cross-linked ionic core micelles
    发明人：BRONICH TATIANA K; KABANOV ALEXANDER V
    权利人:BRONICH TATIANA K; KABANOV ALEXANDER V; UNIV NEBRASKA
    摘要:The present invention provides polymer micelles with cross-linked ionic cores as delivery vehicles for therapeutics, diagnostics, nucleic acids, proteins, small molecules and the like. The present invention provides additionally methods of synthesis and uses for such micelles.

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    主要参考文献


    1: Boni FI, Prezotti FG, Cury BS. Gellan gum microspheres crosslinked with trivalent ion: effect of polymer and crosslinker concentrations on drug release and mucoadhesive properties. Drug Dev Ind Pharm. 2016 Aug;42(8):1283-90. doi: 10.3109/03639045.2015.1125915. Epub 2016 Jan 29. doi: 10.1002/adma.201501602. Epub 2015 Jul 24.
    3: Rao Z, Sasaki M, Taguchi T. Development of amphiphilic, enzymatically-degradable PEG-peptide conjugate as cell crosslinker for spheroid formation. Colloids Surf B Biointerfaces. 2013 Jan 1;101:223-7. doi: 10.1016/j.colsurfb.2012.06.033. Epub 2012 Jul 4.

    合成参考文献


    参考文献:10.1038/sj.mn.7800080|10.1038/sj/mn/7800080|10.1080/714049573|10.1080/mic.8.4.265.274|10.1111/j.1549-8719.2001.tb00175.x
    摘要:UNGVARI Z, KOLLER A. Mediation of EDHF‐Induced Reduction of Smooth Muscle [Ca2+]iand Arteriolar Dilation by K+Channels, 5,6‐EET, and Gap Junctions. Microcirculation. 2001 Aug;8(4):265–74. doi: 10.1111/j.1549-8719.2001.tb00175.x.
    参考文献:10.1016/j.febslet.2006.05.069
    摘要:Komen JC, Wanders RJ. Identification of the cytochrome P450 enzymes responsible for the omega-hydroxylation of phytanic acid. FEBS Lett. 2006 Jul 10;580(16):3794–8. doi: 10.1016/j.febslet.2006.05.069.
    参考文献:10.1016/s0021-9258(17)38832-4
    摘要:Shak S, Reich NO, Goldstein IM, Ortiz de Montellano PR. Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Suicidal inactivation by acetylenic fatty acids. Journal of Biological Chemistry. 1985 Oct;260(24):13023–8. doi: 10.1016/s0021-9258(17)38832-4.
    参考文献:10.1152/ajpregu.00482.2003
    摘要:Lee SJ, Landon CS, Nazian SJ, Dietz JR. CytochromeP-450 metabolites in endothelin-stimulated cardiac hormone secretion. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2004 May;286(5):R888–93. doi: 10.1152/ajpregu.00482.2003.
    参考文献:10.1152/ajprenal.00194.2004
    摘要:Wang X, Hollenberg MD, Loutzenhiser R. Redundant signaling mechanisms contribute to the vasodilatory response of the afferent arteriole to proteinase-activated receptor-2. American Journal of Physiology-Renal Physiology. 2005 Jan;288(1):F65–75. doi: 10.1152/ajprenal.00194.2004.
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