CAS: 331947-66-1; (+)-Tolvaptan

该化合物是一种选择性的,非光化的血管压抑剂V2受体对立物,主要用于与低血糖和单细胞主要多细胞肾病(ADPKD)有关的药理研究和治疗应用.它的相对纯度确保了对V2受体的高度特殊性,尽量减少了目标外的影响.复合物的外表具有很强的横向活动,它抑制了在肾脏收集管道中气压抑制导致的水再吸附,因此对研究液体平衡失调很有价值. (R-(+)-(Tolvaptan)的特点是其生物利用率和代谢稳定性很高,便于进行可靠的体外和体外研究.其定义精细的立体化学和持续能量使它成为分析和临床前研究的首选参考标准.

英文名称(+)-Tolvaptan
中文名称(R)-(+)-托伐普坦
CAS编号331947-66-1
FDA UNII编号:1E2497LPNY
分子式:C26H25ClN2O3分子量:448.949
产品CID: 1326186
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: GYHCTFXIZSNGJT-XMMPIXPASA-N
1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)/t2
计算化学: 氢键受体数3.0氢键供体数2.0可旋转键数3.0

MSDS等安全信息

上下游产品

(R)-7-chloro-5-methoxymethyloxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine MOP-21826 (R)-7-chloro-5-methoxymethyloxy-2,3,4,5-tetrahydro-1H-1-benzazepine (R)-7-chloro-5-hydroxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

合成工艺路线路线简述

📜(R)-5-Acetoxy-7-Chloro-1-(P-Toluenesulfonyl)-2,3,4,5-Tetrahydro-1H-1-Benzazepine置于吡啶,盐酸,Sodium Hydride,Potassium Carbonate,Magnesium体系中,用甲醇,二氯甲烷,N,N-二甲基甲酰胺用作溶剂,化学反应 24.5H,反应生成(R)-(+)-托伐普坦
参考文献:An Efficient Synthesis Of Optical Isomers Of Vasopressin V2 Receptor Antagonist Opc-41061 By Lipase-Catalyzed Enantioselective Transesterification
标题:An Efficient Synthesis Of Optical Isomers Of Vasopressin V2 Receptor Antagonist Opc-41061 By Lipase-Catalyzed Enantioselective Transesterification
摘要:The Optically Active Enantiomers Of 7-Chloro-5-Hydroxy-1-[2-Methyl-4-(2-Methylbenzoylamino)Benzoyl]-2,3,4,5-Tetrahydro-1H-1-Benzazepine (Opc-41061,1) Were Enantioselectively Synthesized. The Chiral Acetate ((R)-(-)-3) And The Chiral Alcohol ((S)-(+)-2) Were Prepared Via The Resolution Of The Racemic Alcohol ((+/-)-2) Using The Lipase-Mediated Transesterification With Vinyl Acetate. Compounds ((R)-(-)-3) And ((S)-(+)-2) Were Converted To Optically Active 1.
Doi:10.3987/com-99-S(I)2