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参考文献:Mattson,Ronald J.;Sloan,Charles P.,J. Org. Chem.,55,(1990) N0,C. 3410-3412
标题:Mattson,Ronald J.;Sloan,Charles P.,J. Org. Chem.,55,(1990) N0,C. 3410-3412
专利信息
专利号:US-6103865-A
优先权日:1998-08-03
标 题 :PH-sensitive polymer containing sulfonamide and its synthesis method
发明人:BAE YOU HAN; PARK SANG YEOB
权利人:KWANGJU INST SCI & TECH
摘要:There are disclosed pH-sensitive polymers containing sulfonamide groups, which can be changed in physical properties, such as swellability and solubility, depending on pH and which can be applied for a drug-delivery system, bio-material, sensor, etc, and a preparation method therefor. The pH-sensitive polymers are prepared by introduction of sulfonamide groups, various in pKa, to hydrophilic groups of polymers either through coupling to the hydrophilic groups, such as acrylamide, N,N-dimethylacrylamide, acrylic acid, N-isopropylacrylamide, etc, of polymers or copolymerization with other polymerizable monomers. These pH-sensitive polymers may have a structure of linear polymer, grafted copolymer, hydrogel or interpenetrating network polymer.