CAS: 277756-46-4; 1-(Trifluoromethyl)Cyclopropanecarboxylic Acid

相似化合物

371917-17-8 1314397-71-1 1273565-75-5

上下游产品

CAS号598-10-7 1,1-环丙基二羧酸 | CAS号1559-02-0 1,1-环丙基二羧酸二乙酯 | CAS号208242-25-5 1-三氟甲基环丙烷-1-羧酸甲酯 | CAS号1022154-58-0 (2-methyl-1-tri... | CAS号371917-17-8 (1-(三氟甲基)环丙基)甲醇

1,1-环丙基二羧酸置于sulfur Tetrafluoride,水,碳酸氢钠体系中,化学反应 3.0H,以36%的收率获得1-三氟甲基环丙烷-1-羧酸
参考文献:1,1-环烷二羧酸与sf 4的选择性反应.通往1,1-双(三氟甲基)环烷烃,1-氟甲酰基-1-(三氟甲基)环烷烃和1-(三氟甲基)-1-环烷烃羧酸的途径
标题:1,1-环烷二羧酸与sf 4的选择性反应.通往1,1-双(三氟甲基)环烷烃,1-氟甲酰基-1-(三氟甲基)环烷烃和1-(三氟甲基)-1-环烷烃羧酸的途径
摘要:通过相应的二酯(1A-D)的碱水解合成了六元,五元,四元和三元的1,1-环烷二羧酸(2A-D),并研究了前者与sf 4的反应.1,1-双(三氟甲基)环烷烃(3A-d)是在120-150oc下进行的反应产物,而在30oc时仅形成1-氟甲酰基-1-(三氟甲基)环烷烃(4A-d) .后者被分离为纯化合物或原位转化为1-(三氟甲基)-1-环烷羧酸(5A-d).
Doi:10.1016/s0022-1139(99)00233-X

专利信息

专利号:US-9676783-B2
优先权日:2008-10-22
标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

专利号:DK-2725028-T3
优先权日:2008-10-22
标题:Substituted pyrazolo [1,5-a] pyrimidine compounds as intermediates in the synthesis of kinase inhibitors TRK

专利号:EP-2725028-A1
优先权日:2008-10-22
标题 :Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors

专利号:EP-2725028-B1
优先权日:2008-10-22
标题 :Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors

专利号:HU-E030413-T2
优先权日:2008-10-22
标 题:Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors

专利号:ES-2588504-T3
优先权日:2008-10-22
标题 :Pyrazolo [1,5-a] pyrimidine compounds substituted as intermediates in the synthesis of TRK kinase inhibitors