CAS: 2486-75-1; 4-Amino-2-Methylbenzoic Acid

上下游产品

CAS号1975-51-5 2-甲基-4-硝基苯甲酸 | CAS号67081-02-1 5-nitrophthalide | CAS号7647-01-0 盐酸 | CAS号103204-69-9 4-乙酰氨基-2-甲基苯甲酸 | CAS号108-44-1 3-甲基苯胺 | CAS号578-39-2 4-羟基-2-甲基苯甲酸 | CAS号103204-69-9 4-乙酰氨基-2-甲基苯甲酸 | CAS号1975-51-5 2-甲基-4-硝基苯甲酸

4-氨基-2-甲基苯甲醛置于甲酸,盐酸羟胺,Sodium Formate,Sodium Hydroxide体系中,用 乙醇,水 用作溶剂,化学反应生成4-氨基-2-甲基苯甲酸
参考文献:一种弗雷拉纳中间体4-溴-2-甲基苯甲酸的合成方法
标题:一种弗雷拉纳中间体4-溴-2-甲基苯甲酸的合成方法
摘要:本发明提供了一种弗雷拉纳中间体4‑溴‑2‑甲基苯甲酸的合成方法,其特征在于:以3‑甲基苯胺为原料,首先与三氯氧磷进行甲酰化生成2‑甲基‑4‑氨基苯甲醛,再与盐酸羟胺发生反应生成肟,肟脱水得到2‑甲基‑4‑氨基苯腈,接着2‑甲基‑4‑氨基苯腈与氢氧化钠水解得到2‑甲基‑4‑氨基苯甲酸,最后桑德迈尔溴代反应得到4‑溴‑2‑甲基苯甲酸,本专利路线原料廉价易得,没有使用贵金属催化剂,避免了剧毒氰化物的使用,整个生产过程操作简便,利于产业化.

专利信息

专利号:US-2012165520-A1
优先权日:2010-12-23
标题:Process for the synthesis of prodrugs of opioids
发明人：MCGEE PAUL; GARNETT IAN; JUAN E; MANAGE A; CARNIAUX JEAN-FRANCOIS
权利人:MCGEE PAUL; GARNETT IAN; JUAN E; MANAGE A; CARNIAUX JEAN-FRANCOIS
摘要:The present invention provides a process for the synthesis of opioid prodrugs. In particular, the present invention provides a process for the synthesis of opioid prodrugs comprising: treating an opioid, in the form of a salt or a freebase, with a carbonyl synthon to form an activated intermediate and subsequently reacting the activated intermediate with an amine, in the form of a salt or a freebase.

专利号:US-10233182-B2
优先权日:2014-04-04
标题 :Substituted spirocyclic inhibitors of autotaxin
发明人：BABISS LEE; CLARK MATTHEW; KEEFE ANTHONY D; MULVIHILL MARK J; NI HAIHONG; RENZETTI LOUIS; RUEBSAM FRANK; WANG CE; XIE ZHIFENG; ZHANG YING
权利人:X RX INC
摘要:The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.

专利号:US-8450342-B2
优先权日:2007-09-12
标题:Perharidines as CDK inhibitors
发明人：MEIJER LAURENT; BETTAYEB KARIMA; GALONS HERVE; DEMANGE LUC; OUMATA NASSIMA
权利人:MEIJER LAURENT; BETTAYEB KARIMA; GALONS HERVE; DEMANGE LUC; OUMATA NASSIMA; CENTRE NAT RECH SCIENT; UNIV RENNES; UNIV PARIS DESCARTES
摘要:The invention relates to trisubstituted or tetrasubstituted imidazo[4,5b]pyridines, to their uses as well as to a process for manufacturing them. n The compounds of the invention are imidazo[4,5b]pyridines. n The first general synthesis of 3,5,7 imidazo[4,5b]pyridines is disclosed in the description. n The invention founds application, in particular, in the pharmaceutical field.

专利号:CN-118324614-A
优先权日:2024-04-11
标题 :Synthesis method of 2-methyl-4-formaldoxime benzoic acid or derivative thereof