CAS: 22509-74-6; N-Carbethoxyphthalimide

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CAS号541-41-3 氯甲酸乙酯 | CAS号1074-82-4 邻苯二甲酰亚胺钾盐 | CAS号106928-72-7 TERT-BUTYL (1S,... | CAS号104618-31-7 2-(4-羟基环己基)异吲哚-... | CAS号3130-75-4 4-苯二甲酰亚氨基丁酸 | CAS号340-90-9 N-邻苯二甲酰-L-谷氨酸 | CAS号5383-82-4 N-(4-羰苯基)邻苯二甲酰亚胺 | CAS号3343-29-1 N-α-邻苯二酰-L-谷氨酰胺 | CAS号3339-73-9 3-邻二甲酰亚氨基丙酸 | CAS号4443-26-9 6-(1,3-二氧代异吲哚-2-基)己酸 | CAS号4192-28-3 邻苯二甲酰基-L-丙氨酸 | CAS号5115-65-1 邻苯二甲基撷氨酸

邻苯二甲酸亚胺,氯甲酸乙酯置于三乙胺体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 4.0H,以94%的收率获得n-乙氧羰基邻苯二甲酰亚胺
参考文献:发现作为有效和选择性smyd3抑制剂的异恶唑酰胺.
标题:发现作为有效和选择性smyd3抑制剂的异恶唑酰胺.
摘要:我们在此报告了异恶唑酰胺作为有效和选择性set和mynd含域蛋白3(smyd3)抑制剂的发现.高通量筛选(hts)铅化合物1的结构活性关系的阐明提供了有效的和选择性的smyd3抑制剂.描述了sar优化,具有smyd3的小分子的共晶体结构以及化合物的抑制模式(moi)表征.还介绍了化合物的合成,生物学和药代动力学特性.
Doi:10.1021/acsmedchemlett.9B00493

专利信息

专利号:US-4242256-A
优先权日:1977-03-15
标 题 :Synthesis of peptide analogues
发明人：SHARPE ROBERT; SZELKE MICHAEL
权利人:SHARPE ROBERT; SZELKE MICHAEL
摘要:Compounds being analogues of a dipeptide in which the nitrogen atom of the linking amide group of the dipeptide is replaced by trivalent group ##STR1## and in which, optionally, the carbonyl function of this linking group is replaced by the divalent group --CH 2 -- are of value in the synthesis of isosterically modified peptides.

专利号:US-5686599-A
优先权日:1992-05-14
标 题:Synthesis, deprotection, analysis and purification of RNA and ribozymes
发明人：TRACZ DANUTA
权利人:RIBOZYME PHARM INC
摘要:Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.

专利号:US-6649751-B2
优先权日:1992-05-14
标 题:Synthesis, deprotection, analysis and purification of RNA and ribozymes
发明人：USMAN NASSIM; WINCOTT FRANCINE; SWEEDLER DAVID; BEIGELMAN LEONID; DUDYCZ LECH W; GRIMM SUSAN; DIRENZO ANTHONY; TRACZ DANUTA
权利人:SIRNA THERAPEUTICS INC
摘要:Provided is a method for purification and synthesis of RNA molecules that have at least one chemical modification.

专利号:US-7041817-B2
优先权日:1992-05-14
标题:Synthesis, deprotection, analysis and purification of RNA and ribozymes
发明人：USMAN NASSIM; WINCOTT FRANCINE; SWEEDLER DAVID; BEIGELMAN LEONID; DUDYCZ LECH W; GRIMM SUSAN; DIRENZO ANTHONY; TRACZ DANUTA
权利人:SIRNA THERAPEUTICS INC
摘要:Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.

专利号:US-12077484-B2
优先权日:2019-12-23
标 题 :Process for the synthesis of melphalan
发明人：ALLEGRINI PIETRO; BONETTI ANDREA; MOLINARI MARCO; GAMBINI ANDREA
权利人:INDENA SPA
摘要:The invention relates to a process for the preparation of Melphalan (4-[bis(2-chloroethyl)amino]-L-phenylalanine of formula (I)said process comprising the reaction of a 4-amino-L-phenylalanine protected at the carboxy and amino aminoacidic groups with an agent able to convert the aromatic amino group into a group of formula: —N(CH2CH2OS(O)nO−)2, wherein n is 1 or 2 followed by conversion of the —N(CH2CH2OS(O)nO−)2 group into a —N(CH2CH2Cl)2 group.The invention also provides novel intermediates useful for the preparation of Melphalan.

专利号:US-5831072-A
优先权日:1996-03-07
标 题:Process for the preparation of 2'-deoxy-2'-halocoformycins or steroisomers thereof
发明人：TAKEUCHI TOMIO; UMEZAWA SUMIO; TSUCHIYA TSUTOMU; TAKAHASHI YOSHIAKI
权利人:ZAIDAN HOJIN BISEIBUTSU
摘要:An object of this invention is to provide a novel process for the synthesis of a 2'-deoxy-2'-halocoformycin having an inhibitory activity against adenosine deaminase in a practically high yield. Thus, there is provided a process comprising multi-stage reactions with using as the starting intermediate a tert-butyl 1-(3,5-di-O-acyl-2-deoxy-2-halo-β-D-ribofuranosyl or arabinofuranosyl)-5-aminoimidazole-4-carboxylate of formula (II) ##STR1## whereby there are produced a 2'-deoxy-2'-halocoformycin or a 2'-deoxy-2'-epi-2'-halocoformycin of formula (I-a) ##STR2## and also a 2'-deoxy-8-epi-2'-halocoformycin or a 2'-deoxy-8,2'-diepi-2'-halocoformycin of formula (I-b) ##STR3## It is expectable that a 2'-deoxy-2'-halocoformycin and epimers thereof are useful as a drug for lymphocytic leukemias and as drugs for various diseases attributable to the actions of adenosine deaminase.