CAS: 1573-92-8; 9-Oxo-9H-Fluorene-1-Carboxylic Acid

相似化合物

784-50-9 6223-83-2 792-26-7

上下游产品

fluoranthene 1-methylfluoren-9-one 9H-fluorene-1-carboxylic acid 2-(2-aminobenzoyl)benzoic acid 9-fluorenone-1-carboxylic acid methyl ester 1-ethoxycarbonylfluorenone 9-fluorenone biphenyl-2,3'-dicarboxylic acid

📜荧蒽置于potassium Dichromate体系中,用99%的收率获得9-芴酮-1-羧酸
参考文献:通过更环保的途径对多环芳族化合物衍生的新型配体金属配合物进行抗癌活性研究.
标题:通过更环保的途径对多环芳族化合物衍生的新型配体金属配合物进行抗癌活性研究.
摘要:甲氧基和叔丁基取代的甲酰胺,羧酸和腙席夫碱基团已组装到我们新设计的芴酮基配体中,并制备了一些第一行过渡金属的配位化合物,并通过光谱(1 H 和13 C NMR,Ir,Gc-Ms,Uv-Vis),分析,Tga 和摩尔电导测量.发现所有金属配合物的化学计量比为 1: 2 (M: L 2 ),通式为 [m(L) 2],其中 L 是单个去质子化的配体,所有金属配合物的几何形状都是八面体.配体及其金属配合物成功切割 Pbr322 质粒 Dna,在对 Mcf-7(人乳腺癌)细胞系具有抗癌活性的情况下,合成的化合物具有优异的活性和显着的细胞凋亡作用,其特征是细胞收缩,细胞破裂并与标准药物顺铂进行了比较.对于化合物 L 1 H,Cu(L 1 ) 2,Cu(L 2 ) 2,Ni(L 1 ) 2和 Ni(L 2 ) 2观测到非常显着的抗癌活性ic 50值<10 μgml-1.进行分子对接研究以评估合成化合
Doi:10.1016/j.Jorganchem.2020.121219

专利信息

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:US-7858824-B2
优先权日:2001-10-18
标 题 :Aralkyltetrahydropyridines, their preparation and pharmaceutical compositions containing them
发明人：BARONI MARCO; BOURRIE BERNARD; CARDAMONE ROSANNA; CASELLAS PIERRE
权利人:SANOFI AVENTIS
摘要:The present invention relates to compounds of formula (III o ): n nin whichn n is an integer from 1 to 5; A o represents a partially saturated carbonaceous bi- or tricycle; it also relates to their salts, solvates, N-oxides, the pharmaceutical compositions containing them, a method for their preparation and synthesis intermediates in this method.