CAS: 136379-59-4; 2,2'-((((5R,6R,7S,9S,11R,18R,19S)-19-Amino-11,18-Dihydroxy-5,9-Dimethylicosane-6,7-Diyl)Bis(Oxy))Bis(2-Oxoethane-2,1-Diyl))Disuccinic Acid

专利信息

专利号:US-2025147014-A1
优先权日:2022-02-14
标题:Plasmon-enhanced fluorescence biochemical sensors
发明人：PINCHUK ANATOLI; SERGEYEVA TETYANA; YARYNKA DARIA; CHEGEL VLADIMIR; LOPATYNSKYI ANDRI
权利人:UNIV COLORADO REGENTS; THE REGENTS OF THE UNIV OF COLORADO A BODY
摘要:A highly sensitive technology enabling selective recognition of aflatoxins such as in contaminated cereal samples. Methods for the synthesis of AgNP-containing MIP membranes from the monomer mixtures containing both methacrylate monomers and oligomers as well as AgNOs solution in dimethylformamide enable the detection system. The AgNP were formed in the structure of the polymeric membranes during the pre-heating step followed by the UV-initiated polymerization. The highly selective sensor elements where MIP membranes are combined with the Ag nanostructures as signal amplifiers (LSPR-MIP nanochips) can be stored separately and used with a simple optical recognition system as selective elements of point-of-care sensor devices, even in in-field conditions. Composite plasmonic membranes provide both highly selective recognition of the target toxin and the generation of an enhanced optical signal, allowing aflatoxin B1 detection at ultralow concentrations.