CAS: 125-84-8; Aminoglutethimide

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CAS号38527-73-0 3-乙基-3-(4-硝基苯基)... | CAS号74220-50-1 2-ethyl-2-pheny... | CAS号769-68-6 α-苯基丁腈 | CAS号140-29-4 苯乙腈 | CAS号77-21-4 格鲁米特 | CAS号98-95-3 硝基苯 | CAS号6973-78-0 Benzeneacetic a... | CAS号183663-77-6 1-hydroxy-3-eth... | CAS号183663-75-4 1-benzyloxy-3-e... | CAS号55511-44-9 (R)-(+)-氨鲁米特 | CAS号57288-03-6 (S)-(-)-氨鲁米特 | CAS号61435-64-1 3-iodo-4-aminog...

3-乙基-3-(4-硝基苯基)-2,6-哌啶二酮置于palladium 10% On Activated Carbon,氢气体系中,用 甲醇 用作溶剂,化学反应 15.0H,反应生成氨鲁米特
参考文献:钴催化醚的直接氨基羰基化:高效获得 α-酰胺取代的醚衍生物
标题:钴催化醚的直接氨基羰基化:高效获得 α-酰胺取代的醚衍生物
摘要:已经实现了醚与胺的新型钴催化羰基化偶联以构建α-羰基化醚.阿夫唑嗪是一种治疗良性前列腺增生(bph)的药物,可以通过这个过程直接合成.
Doi:10.1002/anie.202203797

专利信息

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:US-12209023-B2
优先权日:2017-01-25
标题:Low temperature, high yield synthesis of hydrogen terminated highly porous amorphous silicon, and nanomaterials and composites from Zintl phases
发明人：WAGNER MICHAEL J; BANEK NATHAN A
权利人:UNIV GEORGE WASHINGTON
摘要:The present disclosure relates to an improved process for the synthesis of hydrogen terminated silicon from Zintl phases. The hydrogen terminated silicon is useful, for example, as explosives, chemical and biochemical sensors, optoelectronic materials and Li-ion battery anode ion storage materials. The present disclosure also relates to an improved process for the synthesis of nanomaterials and composites from Zintl phases. The nanomaterials and composites are useful, for example, as ion storage materials.

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.