CAS: 98105-99-8; 6-Fluoro-1-(4-Fluorophenyl)-4-Oxo-7-(Piperazin-1-yl)-1,4-Dihydroquinoline-3-Carboxylic Acid

上下游产品

7-(4-Ethoxycarbonyl-piperazin-1-yl)-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid piperazine 6,7-difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ethyl 2,4,5-trifluorobenzoylacetate1-(p-fluorophenyl)-6-fluoro-7-(4-butyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid naringenin-ethylidene-sarafloxacin apigenin-ethylidene-sarafloxacin genistin-ethylidene-sarafloxacin

2-(2,4-二氯-5-氟苯甲酰基)-3-乙氧基丙烯酸乙酯置于sodium Hydroxide,Sodium Hydride体系中,用 四氢呋喃,乙二醇二甲醚,乙醇,二氯甲烷 作为反应溶剂,化学反应 33.0H,反应生成 沙拉沙星
参考文献:Synthesis And Structure-Activity Relationships Of Novel Arylfluoroquinolone Antibacterial Agents
标题:Synthesis And Structure-Activity Relationships Of Novel Arylfluoroquinolone Antibacterial Agents
摘要:A Series Of Novel Arylfluoroquinolones Has Been Prepared. These Derivatives Are Characterized By Having A Fluorine Atom At The 6-Position,Substituted Amino Groups At The 7-Position,And Substituted Phenyl Groups At The 1-Position. Structure-Activity Relationship (Sar) Studies Indicate That The In Vitro Antibacterial Potency Is Greatest When The 1-Substituent Is Either P-Fluorophenyl Or P-Hydroxyphenyl And The 7-Substituent Is Either 1-Piperazinyl,4-Methyl-1-Piperazinyl,Or 3-Amino-1-Pyrrolidinyl. The Electronic And Spatial Properties Of The 1-Substituent,As Well As The Steric Bulk,Play Important Roles In The Antimicrobial Potency In This Class Of Antibacterials. As A Result Of This Study,Compounds 45 And 41 Were Found To Possess Excellent In Vitro Potency And In Vivo Efficacy.
DOI:10.1021/jm00149A003

专利信息

专利号:US-2025179012-A1
优先权日:2022-03-04
标 题:Synthesis of sulfur(vi) compounds and reagents for same
发明人：LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

专利号:WO-2025101716-A1
优先权日:2023-11-07
标题:Processes for synthesis of trifunctionalized sulfur(vi) compounds
发明人：LOPCHUK JUSTIN; SHULTZ ZACHARY; ATHAWALE PARESH
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure describes processes for the asymmetric synthesis of trifunctionalized sulfur(VI) containing organic compounds of Formula I and Formula VI, as well as compounds of Formula I and Formula VI prepared by the processes described.

专利号:US-11332444-B2
优先权日:2018-04-25
标题:Method for the hydrolysis of quinolonecarboxylic esters
发明人：FEY PETER; BERWE MATHIAS; WIRTHS Joerg; WISCHNAT RALF; LONGERICH MARKUS; DIETZEL ANTJE
权利人:BAYER ANIMAL HEALTH GMBH
摘要:Quinolonecarboxylic esters of the general formula (II) are hydrolyzed to quinolonecarboxylic acids of the general formula (I):The method comprises the step A):A) reacting compounds of the formula (II) with a mixture comprising acetic acid, sulfuric acid and waterIn step A), ≥30 to ≤40 mol of acetic acid, ≥0.3 to ≤1 mol of sulfuric acid and ≥0.9 to ≤2.5 mol of water are used per mole of compounds of the formula (II). The method is particularly suitable for the synthesis of the intermediate (I) in the synthesis of pradofloxacin.

专利号:US-8093381-B2
优先权日:2007-05-24
标题:Method of synthesis of fluoroquinolones
发明人：BERTHON-CEDILLE LAURENCE; LEGUERN MARIE-EMMANUELLE; RENAUD GILLES; TOMBRET FRANCIS
权利人:BERTHON-CEDILLE LAURENCE; LEGUERN MARIE-EMMANUELLE; RENAUD GILLES; TOMBRET FRANCIS; BIOCODEX
摘要:The invention relates to a method of preparation of fluoroquinolones of formula (I) from compounds of formula (II): n nin which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and X are as defined in Claim 1.

专利号:US-2009054643-A1
优先权日:2007-05-24
标 题:Novel method of synthesis of fluoroquinolones

专利号:WO-2023168108-A2
优先权日:2022-03-04
标 题 :Synthesis of sulfur(vi) compounds and reagents for same