CAS: 890655-80-8; 1-(2-Isopropoxyethyl)-2-Thioxo-2,3-Dihydro-1H-Pyrrolo[3,2-D]Pyrimidin-4(5H)-One
- 英文名称1-(2-Isopropoxyethyl)-2-Thioxo-2,3-Dihydro-1H-Pyrrolo[3,2-D]Pyrimidin-4(5H)-One
- 中文名称1-(2-异丙氧基乙基)-2-硫代-2,3-二氢-1H-吡咯并[3,2-d]嘧啶-4(5H)-酮
- IUPAC名称1-(2-isopropoxyethyl)-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
- CAS编号890655-80-8
- MFCD编号:MFCD30533444
- EINECS号:682-454-5
- FDA UNII编号:TT3345YXVR
- 分子式:C11H15N3O2S分子量:253.33
- 产品CID: 1912024
- 产品分类有机原料 → 有机杂环化合物 → 吡咯并嘧啶类
MSDS等安全信息
欧盟法规
C&L通报合成工艺路线路线简述
📜Ethyl 3-(3-Benzoyl-1-(2-Isopropoxyethyl)Thioureido)-1H-Pyrrole-2-Carboxylate置于甲醇,Sodium Hydroxide体系中,化学反应 4.0H,以58 G的收率获得产物1-(2-异丙氧基乙基)-2-硫代-2,3-二氢-1H-吡咯并[3,2-D]嘧啶-4(5H)-酮
参考文献: Process For The Preparation Of Verdiperstat[fr] Procédé De Préparation De Verdiperstat
标题: Process For The Preparation Of Verdiperstat[fr] Procédé De Préparation De Verdiperstat
摘要:公开了一种改进的制备维地帕斯塔的过程.该过程包括以下步骤:将具有以下式的化合物或其盐与3-(二甲氨基)丙烯腈反应,其中r相同或不同,分别是c1-C5烷基,以获得具有以下式的化合物;并将具有以下式的化合物转化为维地帕斯塔.
海关参考信息
- 2905122000-异丙醇
2909110000-乙醚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Kaindlstorfer C, Sommer P, Georgievska B, Mather RJ, Kugler AR, Poewe W, Wenning GK, Stefanova N. Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications. Neurotox Res. 2015 Oct;28(3):185-94. doi: 10.1007/s12640-015-9547-7. Epub 2015 Jul 21.
2: Jucaite A, Svenningsson P, Rinne JO, Cselényi Z, Varnäs K, Johnström P, Amini N, Kirjavainen A, Helin S, Minkwitz M, Kugler AR, Posener JA, Budd S, Halldin C, Varrone A, Farde L. Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease. Brain. 2015 Sep;138(Pt 9):2687-700. doi: 10.1093/brain/awv184. Epub 2015 Jul 1. doi: 10.1016/j.nucmedbio.2015.02.001. Epub 2015 Feb 8.
合成参考文献
参考文献:10.1126/sciadv.abf8711
摘要:Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Carvalho Martins L, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N, Kratochvil HT; QCRG Structural Biology Consortium, Aimon A, Bennett JM, Brandao Neto J, Cohen AE, Dias A, Douangamath A, Dunnett L, Fedorov O, Ferla MP, Fuchs MR, Gorrie-Stone TJ, Holton JM, Johnson MG, Krojer T, Meigs G, Powell AJ, Rack JGM, Rangel VL, Russi S, Skyner RE, Smith CA, Soares AS, Wierman JL, Zhu K, O'Brien P, Jura N, Ashworth A, Irwin JJ, Thompson MC, Gestwicki JE, von Delft F, Shoichet BK, Fraser JS, Ahel I. Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. Sci Adv. 2021 Apr;7(16).
摘要:S55 | ZINC15PHARMA | Pharmaceuticals from ZINC15 | DOI:10.5281/zenodo.3247749
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