专利号:US-5877296-A 优先权日:1994-06-03 标题:Process for preparing conjugates of methyltrithio antitumor agents 发明人:HAMANN PHILIP ROSS; HINMAN LOIS; HOLLANDER IRWIN 权利人:AMERICAN CYANAMID CO 摘要:This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.
专利号:US-5739116-A 优先权日:1994-06-03 标题:Enediyne derivatives useful for the synthesis of conjugates of methyltrithio antitumor agents
专利号:US-5663449-A 优先权日:1989-05-19 标 题 :Intermediate compounds in the synthesis of heteroarylpiperidines, pyrrolidines and piperazines
专利号:EP-0729465-B1 优先权日:1993-11-19 标 题:Pyrone derivatives as protease inhibitors and antiviral agents 发明人:DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN 权利人:PARKE DAVIS & CO 摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.
专利号:IL-132974-A 优先权日:1994-06-03 标 题:Compounds useful in the synthesis of conjugates of methyltrithio anti-tumour agents
专利号:US-5767285-A 优先权日:1994-06-03 标题 :Linkers useful for the synthesis of conjugates of methyltrithio antitumor agents