CAS: 850568-01-3; (2-(Bromomethyl)-4-Fluorophenyl)Boronic Acid

该化合物是一种有机体化合物,其特点是存在一种碳酸功能组,众所周知,它能够与二醇形成可逆的共价联系,使其在各种应用中有用,包括有机合成和药用化学.该化合物具有溴甲基组和氟联苯混合物的特点,有助于其反应性和进一步功能化的潜力.典型的情况是,溴酸在极地溶剂中表现出中等溶解性,并能够参与交叉反应,例如铃木-米亚乌拉混合,这对形成碳-碳联系很有价值.溴原子的存在增强了其电子哲学特性,而氟原子可以影响芳香环的电子特性.

英文名称(2-(Bromomethyl)-4-Fluorophenyl)Boronic Acid
中文名称2-溴甲基-4-氟苯基硼酸
IUPAC名称(2-(bromomethyl)-4-fluorophenyl)boronic acid
其它别名(2-Bromomethyl-4-Fluorobenzene)Boronic Acid; 2-Bromomethyl-4-Fluorophenylboronic Acid; 2-(Bromomethyl)-4-Fluorobenzeneboronicacid; 2-Borono-5-Fluorobenzyl Bromide; 2-(Bromomethyl)-4-Fluorobenzeneboronic Acid ; Boronic Acid, B-[2-(Bromomethyl)-4-Fluorophenyl]-
CAS编号850568-01-3
MFCD编号:MFCD06659867
分子式:C7H7BBrFO2分子量:232.85
产品CID: 1843450
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: SAHGEZUSQVBFDM-UHFFFAOYSA-N
InChI=1S/C7H7BBrFO2/c9-4-5-3-6(10)1-2-7(5)8(11)12/h1-3,11-12H,4H2
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数2.0

MSDS等安全信息

GHS符号GHS05
警示词Danger
危险描述H302-H314
防范说明P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501
危险等级8
UN编号3261.0
危险品标志Xi
风险等级Irritant/Keep Cold
包装等级Ⅱ
安全声明H303+H313+H333

上下游产品

4-氟-2-甲基苯硼酸 4-Fluoro-2-Methylphenylboronic Acid 139911-29-8

合成工艺路线路线简述

139911-29-8 = 850568-01-3
反应条件:1.1 Reagents: Bromine Solvents: Carbon Tetrachloride; 60 Min,Reflux; 60 Min,Reflux
标题:Fluorinated Boronic Acid-Appended Bipyridinium Salts For Diol Recognition And Discrimination Via 19F Nmr Barcodes
作者:Axthelm,Joerg; Goerls,Helmar; Schubert,Ulrich S.; Schiller,Alexander
参考文献:Journal Of The American Chemical Society 日期:2015 卷标:137(49) 页码:15402-15405

📜4-氟-2-甲基苯硼酸置于溴体系中,用四氯化碳作为反应溶剂,化学反应 2.5H,以64%的收率获得产物2-溴甲基-4-氟苯基硼酸
参考文献:Fluorinated Boronic Acid-Appended Bipyridinium Salts For Diol Recognition And Discrimination Via 19F NMR Barcodes
标题:Fluorinated Boronic Acid-Appended Bipyridinium Salts For Diol Recognition And Discrimination Via 19F NMR Barcodes
摘要:Fluorinated Boronic Acid-Appended Benzyl Bipyridinium Salts,Derived From 4,4'-,3,4'-,And 3,3'-Bipyridines,Were Synthesized And Used To Detect And Differentiate Diol-Containing Analytes At Physiological Conditions Via F-19 NMR Spectroscopy. An Array Of Three Water-Soluble Boronic Acid Receptors In Combination With F-19 NMR Spectroscopy Discriminates Nine Diol-Containing Bioanalytes-Catechol,Dopamine,Fructose,Glucose,Glucose-1-Phosphate,Glucose-6-Phosphate,Galactose,Lactose,And Sucrose-At Low Mm Concentrations. Characteristic NMR Fingerprints Are Interpreted As Two-Dimensional Barcodes Without The Need Of Multivariate Analysis Techniques.
DOI:10.1021/jacs.5B10934