CAS: 850173-95-4; N,N-Diethyl-4-(5-Hydroxyspiro[chromene-2,4'-Piperidine]-4-yl)Benzamide,Hydrochloride
- 英文名称N,N-Diethyl-4-(5-Hydroxyspiro[chromene-2,4'-Piperidine]-4-yl)Benzamide,Hydrochloride
- 中文名称N,N-二乙基-4-(5-羟基螺[2H-1-苯并吡喃-2,4'-哌啶]-4-基)苯甲酰胺盐酸盐
- IUPAC名称N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidin]-4-yl)benzamide hydrochloride
- 其它别名N,N-Diethyl-4-(5-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-4-yl)benzamide hydr°Chloride
- CAS编号850173-95-4
- MFCD编号:MFCD17215194
- EINECS号:0
- 分子式:C24H29ClN2O3分子量:428.95166
- 产品CID: 1842380
- 同类组份化合物CAS850305-06-5 (ADL 5859 free base)
- 产品分类生物化工 → 抑制剂 → 神经信号通路(Neuronal Signaling)
物理性质
MSDS等安全信息
上下游产品
tert-butyl 4-(4-(diethylcarbamoyl)phenyl)-5-(methoxymethoxy)spiro[chromene-2,4'-piperidine]-1'-carboxylate合成工艺路线路线简述
📜Tert-Butyl 4-(4-(Diethylcarbamoyl)Phenyl)-5-(Methoxymethoxy)Spiro[chromene-2,4'-Piperidine]-1'-Carboxylate置于盐酸体系中,用 1,4-二氧六环,甲醇 作为反应溶剂,化学反应 16.0H,以100%的收率获得产物n,N-二乙基-4-(5-羟基螺[2H-1-苯并吡喃-2,4'-哌啶]-4-基)苯甲酰胺盐酸盐
参考文献: Spirocyclic Heterocyclic Derivatives And Methods Of Their Use[fr] Derives Heterocycliques Spirocycliques Et Leurs Methodes D'Utilisation
标题: Spirocyclic Heterocyclic Derivatives And Methods Of Their Use[fr] Derives Heterocycliques Spirocycliques Et Leurs Methodes D'Utilisation
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902500000-苯乙烯
2905122000-异丙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Huang P, Tunis J, Parry C, Tallarida R, Liu-Chen LY. Synergistic antidepressant-like effects between a kappa opioid antagonist (LY2444296) and a delta opioid agonist (ADL5859) in the mouse forced swim test. Eur J Pharmacol. 2016 Jun 15;781:53-9. doi: 10.1016/j.ejphar.2016.03.061. Epub 2016 Apr 1. doi: 10.1016/j.bbr.2014.10.029. Epub 2014 Oct 30.
3: Nozaki C, Nagase H, Nemoto T, Matifas A, Kieffer BL, Gaveriaux-Ruff C. In vivo properties of KNT-127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice. Br J Pharmacol. 2014 Dec;171(23):5376-86. doi: 10.1111/bph.12852.
4: van Rijn RM, Harvey JH, Brissett DI, DeFriel JN, Whistler JL. Novel screening assay for the selective detection of G-protein-coupled receptor heteromer signaling. J Pharmacol Exp Ther. 2013 Jan;344(1):179-88. doi: 10.1124/jpet.112.198655. Epub 2012 Oct 24.
合成参考文献
参考文献:10.1007/164_2018_104
摘要:Anand JP, Montgomery D. Multifunctional Opioid Ligands. Handb Exp Pharmacol. 2018;247():21–51. doi: 10.1007/164_2018_104.
参考文献:10.1007/164_2017_32
摘要:Abdallah K, Gendron L. The Delta Opioid Receptor in Pain Control. Handb Exp Pharmacol. 2018;247():147–77. doi: 10.1007/164_2017_32.
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