CAS: 81581-27-3; Ethyl 3-(Benzo[d][1,3]Dioxol-5-yl)-3-Oxopropanoate

该化合物是有机化合物,其复杂结构特征包括苯并[1,3]二氧化物混合物和乙酯功能组,该化合物通常具有与芳香和脂质系统有关的特性,有助于有机溶剂中的潜在反应性和溶解性.二氧化物环的存在表明它可能参与各种化学反应,包括电益替代.乙酯组增强了其亲脂性,使其与酸性形式相比,在有机溶剂中更具溶性.该化合物可能因其潜在的生物活动和药物开发中的应用而对药用化学和有机合成具有兴趣.该化合物的稳定,活性和与生物系统的互动将取决于分子中存在的具体条件和功能组.与许多有机化合物一样,在与该物质打交道时,应当考虑安全数据和处理防范措施.

结构式图片

物理性质

MSDS等安全信息

上下游产品

3,4-亚甲二氧苯乙酮 1-(Benzo[d][1,3]Dioxol-6-yl)Ethanone 3162-29-6
Ethyl 3-(1,3-Benzodioxol-5-yl)-3-Hydroxypropanoate 34023-63-7
胡椒醛 Piperonal 120-57-0
胡椒酸 Piperonylic Acid 94-53-1
甲基 1,3-苯并二恶唑-5-羧酸酯 Methyl 3,4-Methylenedioxybenzoate 326-56-7
胡椒酸酰氯 3,4-(Methylenedioxy)Benzoyl Chloride 25054-53-9

合成工艺路线路线简述

  • 3162-29-6 = 81581-27-3
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Toluene; Rt -> 110 °C1.2 Solvents: Toluene; 10 - 20 Min,110 °C; 110 °C -> Reflux; Reflux -> Rt1.3 Reagents: Acetic Acid; Rt
    标题:Electrochemical Oxidative Cyclization: Synthesis Of Polysubstituted Pyrrole From Enamines
    作者:Chen,Zhiwei; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2021 卷标:2021(6) 页码:951-955]

    = 81581-27-3
    反应条件:1.1 Catalysts: Yttrium Zirconium Oxide Solvents: Dichloromethane; 22 H,Reflux
    标题:Synthesis Of β-Keto Esters Promoted By Yttria-Zirconia Based Lewis Acid Catalyst
    作者:Pandey,Rajesh K.; Et Al
    参考文献:Synthetic Communications 日期:2004 卷标:34(6) 页码:1117-1123]

    34023-63-7 = 81581-27-3
    反应条件:1.1 Reagents: Manganese Oxide (Mno2) Solvents: Dichloromethane; Rt
    标题:Isoxazol-5(4H)One Derivatives As Ptp1B Inhibitors Showing An Anti-Obesity Effect
    作者:Kafle,Bhooshan; Et Al
    参考文献:Chemistry - An Asian Journal 日期:2011 卷标:6(8) 页码:2073-2079]

    37517-78-5 + 94-53-1 = 81581-27-3
    反应条件:1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Tetrahydrofuran
    标题:A Biogenetically Patterned Synthesis Of Deoxycryptopleuridine
    作者:Herbert,Richard B.; Et Al
    参考文献:Heterocycles 日期:1987 卷标:25(1) 页码:409-18]

    141-97-9 + 94-53-1 = 81581-27-3 [标题:Reaction Conditions
    标题:Dioxopyrrolines. Xxvii. Syntheses Of 2-Aryl-3-Ethoxycarbonyl- δ2-Pyrroline-4,5-Diones
    作者:Sano,Takehiro; Et Al
    参考文献:Chemical & Pharmaceutical Bulletin 日期:1984 卷标:32(2) 页码:497-503]

    6148-64-7 + 94-53-1 = 81581-27-3
    反应条件:1.1 Reagents: Triethylamine,Magnesium Chloride Solvents: Tetrahydrofuran; 6 H,25 °C1.2 Reagents: 1,1′-Carbonyldiimidazole Solvents: Tetrahydrofuran; Reflux1.3 Overnight,Reflux1.4 Reagents: Hydrochloric Acid Solvents: Water; Ph 5 - 6,Cooled
    标题:Synthesis Of Dithiolethiones And Identification Of Potential Neuroprotective Agents Via Activation Of Nrf2-Driven Antioxidant Enzymes
    作者:Song,Zi-Long; Et Al
    参考文献:Journal Of Agricultural And Food Chemistry 日期:2020 卷标:68(7) 页码:2214-2231]

    141-97-9 + 25054-53-9 = 81581-27-3
    反应条件:1.1 Solvents: Diethyl Ether,Ethanol2.1 Reagents: Ammonium Hydroxide,Ammonium Chloride Solvents: Water
    标题:Synthesis And Properties Of Several New 3',4'-Methylenedioxyflavones
    作者:Resplandy,A.; Et Al
    参考文献:Annales Pharmaceutiques Francaises 日期:1960 卷标:18 页码:528-41]

    3162-29-6 = 81581-27-3
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Toluene; 1 - 2 H,Reflux; 15 - 20 Min,Reflux; Reflux -> Rt1.2 Reagents: Acetic Acid; Rt
    标题:Iridium-Catalyzed Enantioselective And Diastereoselective Hydrogenation Of Racemic β'-Keto-β-Amino Esters Via Dynamic Kinetic Resolution
    作者:Ling,Fei; Et Al
    参考文献:Advanced Synthesis & Catalysis 日期:2021 卷标:363(20) 页码:4714-4719]

    = 81581-27-3
    反应条件:1.1 Catalysts: Alumina
    标题:Activated Alumina-Promoted Reaction Of Aldehydes With Ethyl Diazoacetate: A Simple Route To β-Oxo Esters
    作者:Dhavale,Dilip D.; Et Al
    参考文献:Journal Of Chemical Research 日期:1994 卷标:(4) 页码:152-3]

    = 81581-27-3
    反应条件:1.1 Catalysts: Niobium Pentachloride Solvents: Dichloromethane; 4.0 H,27 °C
    标题:Niobium(V) Chloride-Catalyzed C-H Insertion Reactions Of α-Diazoesters: Synthesis Of β-Keto Esters
    作者:Yadav,J. S.; Et Al
    参考文献:Tetrahedron 日期:2005 卷标:61(4) 页码:875-878]

    34023-63-7 = 81581-27-3
    反应条件:1.1 Reagents: Manganese Oxide (Mno2) Solvents: Dichloromethane
    标题:Catalytic Enantioselective Nazarov-Cyclizations
    作者:Walz,Irene
    参考文献:2007]

    81581-26-2 = 81581-27-3
    反应条件:1.1 Reagents: Ammonium Hydroxide,Ammonium Chloride Solvents: Water
    标题:Synthesis And Properties Of Several New 3',4'-Methylenedioxyflavones
    作者:Resplandy,A.; Et Al
    参考文献:Annales Pharmaceutiques Francaises 日期:1960 卷标:18 页码:528-41]

    3162-29-6 = 81581-27-3 [标题:Reaction Conditions
    标题:A Visible Light Ru-Catalyzed Photoredox Access To Substituted Dihydrofurans
    作者:Victoria-Miguel,Jorge; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2022 卷标:87(14) 页码:9088-9099]

    105-36-2 = 81581-27-3
    反应条件:1.1 Reagents: Zinc,Ammonium Chloride Solvents: Tetrahydrofuran; Rt1.2 Reagents: Ammonium Chloride Solvents: Water2.1 Reagents: Manganese Oxide (Mno2) Solvents: Dichloromethane; Rt
    标题:Isoxazol-5(4H)One Derivatives As Ptp1B Inhibitors Showing An Anti-Obesity Effect
    作者:Kafle,Bhooshan; Et Al
    参考文献:Chemistry - An Asian Journal 日期:2011 卷标:6(8) 页码:2073-2079]

    1071-46-1 = 81581-27-3
    反应条件:1.1 Reagents: Magnesium Ethoxide Solvents: Tetrahydrofuran2.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Tetrahydrofuran
    标题:A Biogenetically Patterned Synthesis Of Deoxycryptopleuridine
    作者:Herbert,Richard B.; Et Al
    参考文献:Heterocycles 日期:1987 卷标:25(1) 页码:409-18]

    = 81581-27-3
    反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Pentane,Tetrahydrofuran2.1 Reagents: Manganese Oxide (Mno2) Solvents: Dichloromethane
    标题:Catalytic Enantioselective Nazarov-Cyclizations
    作者:Walz,Irene
    参考文献:2007]

    3162-29-6 = 81581-27-3
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; 80 °C; 15 H,80 °C
    标题:Targeting Tubulin Polymerization By Novel 7-Aryl-Pyrroloquinolinones: Synthesis,Biological Activity And Sars
    作者:Bortolozzi,Roberta; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2018 卷标:143 页码:244-258
📜胡椒酸置于氯化亚砜,Sodium Acetate,Sodium Hydride体系中,用 乙醚,乙醇 作为反应溶剂,化学反应 6.75H,反应生成 3-(6-胡椒环基)-3-氧代丙酸乙酯
参考文献:2,6-和2,4-二芳基-3,7-二氧杂双环-[3.3.0]辛烷的合成及核磁共振谱
标题:2,6-和2,4-二芳基-3,7-二氧杂双环-[3.3.0]辛烷的合成及核磁共振谱
摘要:经由相应的苏式和赤式-二氧代二酯制备了一系列的异构体2,6-和2,4-二芳基-3,7-二氧杂双环[3.3.0]辛烷.通过比较它们的1 H和13 C NMR光谱,可以发现化学位移和偶合常数之间的细微差别,这对于将化合物分配给此类化合物具有诊断意义.4-羟基芝麻素的结构已通过与芝麻素的直接相关得到证实.
DOI:10.1039/p19820000183

海关参考信息

专利信息


专利号:CN-107108425-A
优先权日:2014-12-23
标 题:Efficient process for the synthesis of alkoxy-substituted benzaldehydes

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合成参考文献


参考文献:10.1007/s10600-005-0126-7
摘要:Garazd MM, Garazd YL, Khilya VP. Neoflavones. 2. Methods for Synthesizing and Modifying 4-Arylcoumarins. Chemistry of Natural Compounds. 2005 May;41(3):245–71. doi: 10.1007/s10600-005-0126-7.
参考文献:10.1007/978-3-7091-7153-0_4
摘要:Mors WB, Magalhães MT, Gottlieb OR. Naturally Occurring Aromatic Derivatives of Monocyclic α-Pyrones. 1962. In: Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progrès dans la Chimie des Substances Organiques Naturelles. : Springer Vienna; 1962.
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