CAS: 68406-27-9; 20-Gluco-Ginsenoside-Rf

该化合物是来自Panax gunseng的稀有和生物活性沙文. 作为gnsenoside 家族的一员,它呈现出独特的结构特征,包括C-20 位置的葡萄糖,影响其药理特性. 已经研究过该化合物的潜在...

英文名称20-Gluco-Ginsenoside-Rf
中文名称20-葡萄糖人参皂苷R
IUPAC名称(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-((S)-6-methyl-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hept-5-en-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-6-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
其它别名20-O-Glucoginsenoside Rf; (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-Dihydroxy-4,4,8,10,14-Pentamethyl-17-[(2S)-6-Methyl-2-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxyhept-5-En-2-Yl]-2,3,5,6,7,9,11,12,13,15,16,17-Dodecahydro-1H-Cyclopenta[a]Phenanthren-6-Yl]Oxy]-4,5-Dihydroxy-6-(Hydroxymethyl)Oxan-3-Yl]Oxy-6-(Hydroxymethyl)Oxane-3,4,5-Triol; 20-Gluco-Ginsenoside Rf; β-D-Glucopyranoside, (3β,6α,12β)-20-(β-D-Glucopyranosyloxy)-3,12-Dihydroxydammar-24-En-6-Yl 2-O-β-D-Glucopyranosyl-; 20Oglucoginsenoside Rf,20 O Glucoginsenoside Rf
CAS编号68406-27-9
分子式:C48H82O19分子量:963.16
产品CID: 1674400

相似结构搜索
InChIKey: FBFMBWCLBGQEBU-RXMALORBSA-N
InChI=1S/C48H82O19/c1-21(2)10-9-13-48(8,67-42-38(61)35(58)32(55)26(19-50)64-42)22-11-15-46(6)30(22)23(52)16-28-45(5)14-12-29(53)44(3,4)40(45)24(17-47(28,46)7)62-43-39(36(
计算化学: 氢键受体数19.0氢键供体数13.0可旋转键数13.0

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-
防范说明P264-P270-P280-P301+P312+P330-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364-P501-

合成工艺路线路线简述

海关参考信息

2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905143000-叔丁醇
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专利信息

专利号:US-9718850-B2
优先权日:2008-04-08
标题:Triterpene saponins, methods of synthesis and uses thereof
发明人：GIN DAVID; ADAMS MICHELLE; DENG KAI; LIVINGSTON PHILIP; RAGUPATHI GOVINDASWAMI; CHEA ERIC; FERNANDEZ-TEJADA ALBERTO; NORDSTROEM LARS ULRIK; Walkowicz William; GARDNER JEFFREY; TAN DEREK
权利人:MEMORIAL SLOAN-KETTERING INST FOR CANCER RES
摘要:The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.

专利号:CN-106701647-A
优先权日:2016-09-27
标题 :Application of Gynostemma Gynostemma Glycosyltransferase in the Synthesis of Rare Ginsenosides

专利号:US-2014328952-A1
优先权日:2011-12-21
标题:Topical compositions
发明人：FLAVIN DANA
权利人:FLAVIN DANA
摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.

专利号:US-2017283450-A1
优先权日:2008-04-08
标题 :Triterpene saponins, methods of synthesis and uses thereof

专利号:CA-2720771-C
优先权日:2008-04-08
标题:Triterpene saponins, methods of synthesis, and uses thereof

专利号:KR-102453184-B1
优先权日:2008-04-08
标题:Triterpene saponins, methods of synthesis, and uses thereof