CAS: 58755-70-7; 1-Iodo-4-Methoxy-2-Nitrobenzene

该化合物是有机化合物,其特点是有碘原子和硝化物组,附于厌离物结构中的化学物质组;其分子式为C8H8INO3,表明含有8个碳原子,8个氢原子,1个碘原子,一个氮原子,一氮原子和3个氧原子;该化合物的特性是附于一个苯环的甲氧组(-OCH3),该组在3级与硝基(-NO2)和4级与碘原子(I)相替代. 这种替代模式有助于其独特的化学特性,包括其在有机合成和药物中的再活性和潜在应用. 4-Iodo-3-硝基硝醇在室温下一般是固态的,在有机溶剂中可能表现出中等溶性.其再活性可能受到硝基子组和大度碘亚化亚化剂的电吸附性质的影响,因此它成为各种化学反应的有益中间体,包括核分裂替代物和混合反应.在处理这一化合物时,应当采取安全防范措施,因为其具有环境毒性.

英文名称1-Iodo-4-Methoxy-2-Nitrobenzene
中文名称1-碘-4-甲氧基-2-硝基苯
IUPAC名称1-iodo-4-methoxy-2-nitrobenzene
其它别名4-碘-3-硝基苯甲醚; 4-Iodo-3-Nitrophenyl Methyl Ether
CAS编号58755-70-7
MFCD编号:MFCD00024195
EINECS号:621-240-8
分子式:C7H6INO3
分子量:279.03
产品CID: 1562622
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
产品信息参考;;
InChIKey: JWZODIRSJJQOKY-UHFFFAOYSA-N
InChI=1S/C7H6INO3/c1-12-5-2-3-6(8)7(4-5)9(10)11/h2-4H,1H3…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数2.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
急性毒性类别4(吸入)
急性毒性类别4(经皮)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
严重眼刺激类别2
警示词Warning(警告)
危险描述H302 |吞咽有害.
H332 |吸入有害.
H312 |皮肤接触有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi
安全声明S26-S36/37/39
危险类别码R36/37/38

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

3-硝基苯甲醚置于吡啶,碘,硝酸体系中,化学反应生成 4-碘基-3-硝基苯甲醚
参考文献:The Iodination Of Phenol And Cresol Ethers
标题:The Iodination Of Phenol And Cresol Ethers
摘要:
DOI:10.1021/ja01367A042

海关参考信息

2905110000-甲醇
2908991010-4-硝基苯酚
2908199090-其他酚的卤化衍生物
2918290000-其他含酚基羧酸
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-8735586-B2
优先权日:2007-06-26
标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÃ‰ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÃ‰ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:EP-2173747-B1
优先权日:2007-06-26
标题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS
权利人:SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-2010261909-A1
优先权日:2007-06-26
标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:WO-2009000413-A1
优先权日:2007-06-26
标题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:EP-2173721-B1
优先权日:2007-06-26
标题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:KR-20100023907-A
优先权日:2007-06-26
标题:Regioselective Copper Catalytic Synthesis of Benzimidazole and Azabenzimidazole