专利号:WO-9517903-A1 优先权日:1993-12-28 标 题:Modular design and synthesis of oxazolone-derived molecules 发明人:HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG 权利人:ARQULE PARTNERS L P; HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG 摘要:The design and synthesis of novel oxazolone-derived molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs, and have applications in separations and materials science.
专利号:US-4351762-A 优先权日:1981-03-10 标题:Rapid, quantitative peptide synthesis using mixed anhydrides 发明人:VERLANDER MICHAEL S; FULLER WILLIAM D; GOODMAN MURRAY 权利人:BIORESEARCH INC 摘要:In the synthesis of a polypeptide chain wherein an N alpha -urethane-protected amino acid mixed anhydride is coupled with an amino-unprotected second amino acid, the improvement comprising conducting said coupling at room temperature or above. This method provides rapid, essentially quantitative reactions without the necessity for reduced temperatures. The method is particularly useful in the solid-phase synthesis of peptides where shortened coupling cycles and improved yields of substantially pure products are obtained.
专利号:US-2024182642-A1 优先权日:2022-11-23 标 题:Green synthesis of amino acid based poly(ester urea)s 发明人:OLSEN BRADLEY DAVID; FRANSEN KATHARINA 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:Disclosed are methods of synthesizing poly(ester urea)s.
专利号:US-2009275727-A1 优先权日:1998-03-24 标题:Peptide turn mimetics 发明人:CASSIDY PETER J; ALEWOOD PAUL FRANCIS; VERNALL ANDREA JOY 权利人:MIMETICA PTY LTD 摘要:This invention provides novel compounds useful for the synthesis of peptide mimetics, and describes the use of these compounds for the synthesis of novel reverse turn mimetics. The reverse turn mimetics of the invention have the general structure X wherein the variables are as defined herein.
专利号:US-4267344-A 优先权日:1972-09-22 标 题:N-Substituted N-carboxyanhydrides of α-amino acids and their application in the preparation of peptides 发明人:HALSTROM JOHN B; KOVACS KAROLY G 权利人:PROTEINKEMISK INST TILKNYTTET 摘要:N-Substituted N-carboxyanhydrides of α-amino acids, useful in peptide syntheses, and peptide synthesis process using such compounds, are disclosed. The N-substituent is penta(lower alkoxy)benzyl, or optionally substituted 9-xanthyl, 9-thioxanthyl or 9-selenoxanthyl.
专利号:JP-H09511225-A 优先权日:1993-12-28 标 题 :Modular design and synthesis of oxazolone-derived molecules
[参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
合成参考文献
参考文献:10.1007/s00775-003-0489-9 摘要:Kawabe K, Sasagawa T, Yoshikawa Y, Ichimura A, Kumekawa K, Yanagihara N, Takino T, Sakurai H, Kojima Y. Synthesis, structure analysis, solution chemistry, and in vitro insulinomimetic activity of novel oxovanadium(IV) complexes with tripodal ligands containing an imidazole group derived from amino acids. JBIC Journal of Biological Inorganic Chemistry. 2003 Oct 09;8(8):893–906. doi: 10.1007/s00775-003-0489-9. 参考文献:10.1134/s1068162017040045 摘要:Fayrushina AI, Baltina LA, Baltina LA, Konovalova NI, Petrova PA, Eropkin MY. Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters. Russian Journal of Bioorganic Chemistry. 2017 Jul;43(4):456–62. doi: 10.1134/s1068162017040045.