CAS: 5845-53-4; D-Leucine Methyl Ester Hydrochloride

该化合物是一种化学化合物,是氨基酸的衍生物,其特点是白色晶状表面,在水和酒精中可溶解,在各种生化应用中有用;该化合物的特点是甲基酯功能组,与母氨基酸相比,其脂质增加.D-Leucine本身是环环链氨基酸(BCAAs)之一,在蛋白合成和肌肉代谢中发挥着关键作用.盐化形式表明,该化合物是一种盐,可以在水溶溶液中提高其稳定性和溶性.D-Leucine 甲基氢氯化物经常用于浸化物合成,并用作制药和营养学的建筑块块.其特性使其在研究环境中具有价值,特别是在与代谢和肌肉生理学有关的研究中具有价值.与许多化学物质一样,适当的处理和安全防范措施至关重要,因为其使用具有潜在的危害.

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CAS号67-56-1 甲醇 | CAS号328-38-1 D-亮氨酸 | CAS号23032-21-5 H-D-Leu-OMe.HCl | CAS号55322-25-3 N-Benzyloxy-D-l... | CAS号17392-84-6 (S)-2-hydroxy-4... | CAS号328-38-1 D-亮氨酸 | CAS号161832-74-2 (R)-(+)-2-氨基-4-... | CAS号634196-86-4 METHYL 2-(4-(BE...

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    专利号:WO-9517903-A1
    优先权日:1993-12-28
    标 题:Modular design and synthesis of oxazolone-derived molecules
    发明人:HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG
    权利人:ARQULE PARTNERS L P; HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG
    摘要:The design and synthesis of novel oxazolone-derived molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs, and have applications in separations and materials science.

    专利号:US-4351762-A
    优先权日:1981-03-10
    标题:Rapid, quantitative peptide synthesis using mixed anhydrides
    发明人:VERLANDER MICHAEL S; FULLER WILLIAM D; GOODMAN MURRAY
    权利人:BIORESEARCH INC
    摘要:In the synthesis of a polypeptide chain wherein an N alpha -urethane-protected amino acid mixed anhydride is coupled with an amino-unprotected second amino acid, the improvement comprising conducting said coupling at room temperature or above. This method provides rapid, essentially quantitative reactions without the necessity for reduced temperatures. The method is particularly useful in the solid-phase synthesis of peptides where shortened coupling cycles and improved yields of substantially pure products are obtained.

    专利号:US-2024182642-A1
    优先权日:2022-11-23
    标 题:Green synthesis of amino acid based poly(ester urea)s
    发明人:OLSEN BRADLEY DAVID; FRANSEN KATHARINA
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:Disclosed are methods of synthesizing poly(ester urea)s.

    专利号:US-2009275727-A1
    优先权日:1998-03-24
    标题:Peptide turn mimetics
    发明人:CASSIDY PETER J; ALEWOOD PAUL FRANCIS; VERNALL ANDREA JOY
    权利人:MIMETICA PTY LTD
    摘要:This invention provides novel compounds useful for the synthesis of peptide mimetics, and describes the use of these compounds for the synthesis of novel reverse turn mimetics. The reverse turn mimetics of the invention have the general structure X wherein the variables are as defined herein.

    专利号:US-4267344-A
    优先权日:1972-09-22
    标 题:N-Substituted N-carboxyanhydrides of α-amino acids and their application in the preparation of peptides
    发明人:HALSTROM JOHN B; KOVACS KAROLY G
    权利人:PROTEINKEMISK INST TILKNYTTET
    摘要:N-Substituted N-carboxyanhydrides of α-amino acids, useful in peptide syntheses, and peptide synthesis process using such compounds, are disclosed. The N-substituent is penta(lower alkoxy)benzyl, or optionally substituted 9-xanthyl, 9-thioxanthyl or 9-selenoxanthyl.

    专利号:JP-H09511225-A
    优先权日:1993-12-28
    标 题 :Modular design and synthesis of oxazolone-derived molecules
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    主要参考文献

    [参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

    合成参考文献


    参考文献:10.1007/s00775-003-0489-9
    摘要:Kawabe K, Sasagawa T, Yoshikawa Y, Ichimura A, Kumekawa K, Yanagihara N, Takino T, Sakurai H, Kojima Y. Synthesis, structure analysis, solution chemistry, and in vitro insulinomimetic activity of novel oxovanadium(IV) complexes with tripodal ligands containing an imidazole group derived from amino acids. JBIC Journal of Biological Inorganic Chemistry. 2003 Oct 09;8(8):893–906. doi: 10.1007/s00775-003-0489-9.
    参考文献:10.1134/s1068162017040045
    摘要:Fayrushina AI, Baltina LA, Baltina LA, Konovalova NI, Petrova PA, Eropkin MY. Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters. Russian Journal of Bioorganic Chemistry. 2017 Jul;43(4):456–62. doi: 10.1134/s1068162017040045.
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