CAS: 56962-04-0; 3-Bromo-5-Chlorophenol

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CAS号108-37-2 1-溴-3-氯苯 | CAS号174913-12-3 3-溴-5-氯苯甲醚 | CAS号33863-76-2 1-溴-3-氯-5-氟苯 | CAS号108-43-0 3-氯酚 | CAS号87504-69-6 3-chloro-2,4,5,... | CAS号883195-40-2 3-氨基-5-氯苯酚 | CAS号7446-70-0 氯化铝 | CAS号71-43-2 苯 | CAS号960388-56-1 3-氯-5-(4, 4, 5,... | CAS号1004112-67-7 1-溴-3-氯-5-(二氟甲氧基)苯 | CAS号174913-12-3 3-溴-5-氯苯甲醚 | CAS号1187966-48-8 1-(苄氧基)-3-溴-5-氯苯

间氯溴苯置于oxone,1,2-双(二甲基瞵)乙烷,水体系中,用 丙酮 作为反应溶剂,化学反应 0.12H,反应生成 3-溴-5-氯苯酚
参考文献:实用的一锅ch活化/硼氢化/氧化:数克规模的制备3-溴-5-甲基苯酚
标题:实用的一锅ch活化/硼氢化/氧化:数克规模的制备3-溴-5-甲基苯酚
摘要:提出了一种实用的一锅法ch活化/硼化/氧化顺序,用于反应生成3,5-二取代的苯酚.具体地,在不分离中间体的情况下,由3-溴甲苯以数克规模并且以高收率制备3-溴-5-甲基苯酚.该过程在温和的条件下进行,可以在一天之内完成. 苯酚-Ch活化-硼化-氧化-硼酸酯
DOI:10.1055/s-0030-1258443

专利信息

专利号:US-6828466-B2
优先权日:2002-07-19
标题:Process for the synthesis of phenols from arenes
发明人：MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL; SHI FENG
权利人:UNIV MICHIGAN STATE
摘要:A process to synthesize substituted phenols such as those of the general formula RR'R''Ar(OH) wherein R, R', and R'' are each independently hydrogen or any group which does not interfere in the process for synthesizing the substituted phenol including, but not limited to, halo, alkyl, alkoxy, carboxylic ester, amine, amide; and Ar is any variety of aryl or hetroaryl by means of oxidation of substituted arylboronic esters is described. In particular, a metal-catalyzed C-H activation/borylation reaction is described, which when followed by direct oxidation in a single or separate reaction vessel affords phenols without the need for any intermediate manipulations. More particularly, a process wherein Ir-catalyzed borylation of arenes using pinacolborane (HBPin) followed by oxidation of the intermediate arylboronic ester by OXONE is described.

专利号:US-12150934-B2
优先权日:2016-11-30
标 题 :Methods of using substituted pyrazole and pyrazole compounds and for treatment of hyperproliferative diseases
发明人：SIDDIQUI ARSHAD M; CIBLAT STEPHANE; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; GUO XIANGYU; SRIVASTAVA SANJAY; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW W; LUTHER MICHAEL; LEVINE JEDD
权利人:BANTAM PHARMACEUTICAL LLC
摘要:Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by “aâ€?, R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

专利号:US-2004030197-A1
优先权日:2002-07-19
标 题 :Process for the synthesis of phenols from arenes

专利号:US-9856241-B2
优先权日:2013-07-03
标 题:Substituted benzofuranyl and benzoxazolyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula (A), or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

专利号:US-9126942-B2
优先权日:2008-03-08
标题 :Arylsulfonyl pyrazoline carboxamidine derivatives as 5-HT6 antagonists
发明人：VAN LOEVEZIJN ARNOLD; IWEMA BAKKER WOUTER I; STOIT ALEX; RENSINK AGATHA M; VENHORST JENNIFER; VAN DER NEUT MARTINA A W; DE HAAN MARTIN; KRUSE CORNELIS G
权利人:ABBVIE BAHAMAS LTD
摘要:This invention concerns arylsulfonyl pyrazoline carboxamidine derivatives as antagonists of 5-ht6 receptors, to methods for the preparation of these compounds and to novel intermediates useful for their synthesis. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in Parkinson's disease, Huntington's chorea, schizophrenia, anxiety, depression, manic depression, psychoses, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, binge eating disorders, panic attacks, akathisia, attention deficit hyperactivity disorder, attention deficit disorder, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, disorders associated with spinal trauma or head injury, hydrocephalus, functional bowel disorder, irritable bowel syndrome, obesity and type-2 diabetes. The compounds have the general formula (1) wherein the symbols have the meanings given in the description.