CAS: 39684-80-5; Tert-Butyl (2-Bromoethyl)Carbamate

上下游产品

tert-butyl dicarbonatedi-tert-butyl dicarbonate 2-bromoethylamine hydrobromide 2-(N-tert-butoxycarbonylamino)ethanol 2-bromoethylamineethane2-iodo-1-(tert-butyloxycarbonyl)aminoethane [2-(3-[1,3]Dioxolan-2-yl-4-nitro-phenoxy)-ethyl]-carbamic acid tert-butyl ester 3,5-bis-(2-tert-butyloxycarbonylamino-ethoxy) methyl benzoate tert-butyl 2-{3-[3-(3,4-dimethoxyphenyl)propane]phenoxy}ethylcarbamate

2-({[(2-甲基-2-丙基)氧基]羰基}氨基)乙基甲烷磺酸酯置于lithium Bromide体系中,用 四氢呋喃 作为反应溶剂,以96%的收率获得产物n-Boc-溴乙胺
参考文献:Novel Compounds And Compositions For Treating Diseases Asociated With Protease Activity
标题:Novel Compounds And Compositions For Treating Diseases Asociated With Protease Activity
摘要:描述了用于预防和治疗由肥大细胞介导的炎症性疾病的新化合物,组合物和方法.这些化合物,组合物和方法对预防和治疗与呼吸道相关的炎症性疾病(如哮喘和过敏性鼻炎)以及其他类型的免疫介导性炎症性疾病(如类风湿关节炎,结膜炎和炎症性肠病,各种皮肤病症以及某些病毒性疾病)有效.这些化合物包括对肥大细胞蛋白酶组胺酶的有效和选择性抑制剂.用于治疗这些疾病的组合物包括口服,吸入,局部和静脉制剂,以及包含这些制剂的装置.

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-7947701-B2
优先权日:2003-11-14
标题:Dual molecules containing peroxy derivative, the synthesis and therapeutic applications thereof
发明人：CAZELLES JEROME; COSLEDAN FREDERIC; MEUNIER BERNARD; PELLET ALAIN
权利人:SANOFI AVENTIS
摘要:The invention relates to dual molecule compounds containing a peroxide derivative, to processes for the synthesis of such compounds, to pharmaceutical compositions comprising such compounds, and to methods of treatment and prevention of malaria comprising administering such compounds and such pharmaceutical compositions.

专利号:WO-2017214534-A1
优先权日:2016-06-10
标 题:Synthesis of the arylomycin macrocyclic core
发明人：ROMESBERG FLOYD E; BARAN PHIL; PETERS DAVID
权利人:SCRIPPS RESEARCH INST
摘要:The invention provides a copper-mediated process for making compounds according to Formula (I): that are the macrocyclic scaffolds of the arylomycin class of biologically active compounds, where R 1 , R 2 , R 3 , R A1 , R A2 , R A3 , B, G 1 , G 2 , PG, n2, and n3 are defined in the specification.

专利号:US-8399502-B2
优先权日:2008-09-17
标 题 :Analogs of indole-3-carbinol and their use as agents against infection
发明人：JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN
权利人:JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN; STANFORD RES INST INT
摘要:Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2′-diindolylmethane, 2′,3-diindolylmethane, and 3,3′-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.

专利号:US-10793557-B2
优先权日:2018-04-03
标题 :Sting agonist compounds
发明人：ALTMAN MICHAEL D; CASH BRANDON D; CHILDERS MATTHEW LLOYD; CUMMING JARED N; DEMONG DUANE E; HAIDLE ANDREW MARC; HENDERSON TIMOTHY J; JEWELL JAMES P; LARSEN MATTHEW A; LIM JONGWON; LU MIN; OTTE RYAN D; TROTTER BENJAMIN WESLEY
权利人:MERCK SHARP & DOHME
摘要:Compounds of general formula (I), of general formula (II), of general formula (III), of general formula (IV), of general formula (V), of general formula (VI), and their pharmaceutically acceptable salts, wherein all variables are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).