CAS: 32431-84-8; 3-Fluorothiophene-2-Carboxylic Acid

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CAS号527-72-0 2-噻吩甲酸 | CAS号100421-52-1 3-氟-2-噻吩羧酸甲酯 | CAS号109-72-8 正丁基锂 | CAS号133745-75-2 N-氟代双苯磺酰胺 | CAS号22288-78-4 3-氨基-2-噻吩甲酸甲酯 | CAS号147123-67-9 3-氯噻吩-2-甲腈 | CAS号3093-88-7 3-氟噻吩 | CAS号614729-70-3 (3-fluorothioph...

2-噻吩甲酸置于正丁基锂,N-氟代双苯磺酰胺体系中,用 四氢呋喃,正己烷 用作溶剂,化学反应 10.5H,以40%的收率获得3-氟-2-噻吩羧酸
参考文献:通过含有n端3-甲氧基(和3-氯)噻吩残基的发夹形聚酰胺对ta碱基对的形状选择性识别.
标题:通过含有n端3-甲氧基(和3-氯)噻吩残基的发夹形聚酰胺对ta碱基对的形状选择性识别.
摘要:发夹聚酰胺可以选择性识别具有与天然蛋白质相当亲和力的预定dna序列.Dna小槽内不对称芳香环的内部并排对可区分四个watson-Crick碱基对.相比之下,除了im / Py靶向gc碱基对外,N末端环对的特异性较低.为了探索新环对的序列特异性,合成了一系列在n端含有3-取代噻吩-2-羧酰胺残基的发夹形聚酰胺.与py相对的n末端3-甲氧基(或3-氯)噻吩残基相对于at碱基对显示出对ta的选择性是6-(和3-)倍,而对g,C碱基对的影响却> 200倍.
Doi:10.1016/s0968-0896(03)00502-9

专利信息

专利号:US-2010160351-A1
优先权日:2008-12-19
标题:Pharmaceutical compositions and methods for treating hyperuricemia and related disorders
发明人：JENKINS HELEN; KITT MICHAEL; PEARLMAN RODNEY; SERAFINI TITO; THORSETT EUGENE
权利人:NUON THERAPEUTICS INC
摘要:Disclosed is a pharmaceutical composition comprising (a) a first therapeutic agent, wherein the first therapeutic agent is a compound of formula II: n n n n n n n n n n n n or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , X and n are as defined herein; (b) a second therapeutic agent, wherein the second therapeutic agent is a uric acid synthesis inhibitor or a uricosuric agent; and (c) a pharmaceutically acceptable diluent or carrier.

专利号:RO-106402-B1
优先权日:1989-04-18
标 题:DERIVATIVES OF 2-OXINDOL-3-SUBSTITUTES, THE PROCESS OF OBTAINING AND INTERMEDIARIES IN THEIR SYNTHESIS