1,2,3-三甲氧基苯置于n-碘代糖精体系中,用54%的收率获得5-碘-1,2,3-三甲氧基苯 参考文献:Aromatic Iodination Using N-Iodosaccharin In Room Temperature Ionic Liquids 标题:Aromatic Iodination Using N-Iodosaccharin In Room Temperature Ionic Liquids 摘要:More Reactive Iodination Conditions Have Been Developed That Combine The Use Of Room Temperature Ionic Liquids With N-Iodosaccharin. Using These Reaction Conditions,Even Very Modestly Activated Arenes Such As Toluene Can Be Iodinated In Good Yield Under Very Mild Conditions. (C) 2011 Elsevier Ltd. All Rights Reserved. Doi:10.1016/j.Tetlet.2011.03.010
专利号:US-2005130221-A1 优先权日:2001-02-01 标 题:Synthesis for the preparation of compounds for screening as potential tubulin binding agents 发明人:FLYNN BERNARD L; HAMEL ERNEST 权利人:US GOV HEALTH & HUMAN SERV 摘要:The present invention relates to methods for the synthesis of chemical compounds for screening as potential tubulin polymerization inhibitors. The invention also provides chemical compounds with tubulin polymerization inhibitor activity.
专利号:US-8674119-B2 优先权日:2010-07-16 标题 :Chemical processes for the manufacture of substituted benzofurans 发明人:FLYNN BERNARD LUKE 权利人:FLYNN BERNARD LUKE; BIONOMICS LTD 摘要:The present invention relates to the scaled-up synthesis of biologically active compounds which display useful therapeutic activity in treating proliferative disorders. In particular the invention relates to process methods for the kilogram scale synthesis of a particular class of substituted benzofuran tubulin polymerisation inhibitors.
专利号:CA-2435545-A1 优先权日:2001-02-01 标题 :Synthesis for the preparation of compounds for screening as potential tubulin binding agents
专利号:EP-1363880-A1 优先权日:2001-02-01 标题 :Synthesis for the preparation of compounds for screening as potential tubulin binding agents
专利号:EP-1363880-A4 优先权日:2001-02-01 标题:SYNTHESIS FOR THE PREPARATION OF COMPOUNDS FOR SCREENING AS POTENTIAL TUBULIN BINDING MEDIUM
专利号:NZ-527029-A 优先权日:2001-02-01 标题 :Synthesis for the preparation of compounds for screening as potential tubulin binding agents