CAS: 22573-93-9; Alexidine

上下游产品

2-Ethylhexylamine 3-cyano-N1-guanidino)hexane1,6-di-(N3-cyano-N1-guanidino)hexane hexane-1,6-diamine dihydr°Chloride 2-ethyl-hexylamine hydr°Chloride

6-氨基-1-己烷氯化铵 以 正丁醇 用作溶剂,化学反应 9.0H,反应生成己联双辛胍
参考文献:口腔消毒剂抑制抗凋亡蛋白bcl-Xl介导的蛋白质-蛋白质相互作用,并诱导人口腔肿瘤细胞凋亡.
标题:口腔消毒剂抑制抗凋亡蛋白bcl-Xl介导的蛋白质-蛋白质相互作用,并诱导人口腔肿瘤细胞凋亡.
摘要:长期以来,洗必泰和阿莱西丁已被人类用作口服消毒剂.两种化合物均在生理相关浓度下抑制抗凋亡蛋白bcl-X L介导的蛋白-蛋白相互作用,并诱导一系列源自舌头和咽部的肿瘤细胞系的凋亡(见图).抑制蛋白质之间的相互作用是当前人类使用药物的一种潜在作用方式.
Doi:10.1002/anie.201208889

专利信息

专利号:US-9951096-B2
优先权日:2008-08-22
标 题 :Catalysts and methods for polymer synthesis
发明人：ALLEN SCOTT D; CHERIAN ANNA E; SIMONEAU CHRIS A; FARMER JAY J; COATES GEOFFREY W; GRIDNEV ALEXEI; LAPOINTE ROBERT E
权利人:SAUDI ARAMCO TECH CO
摘要:The present invention provides unimolecular metal complexes having increased activity in the copolymerization of carbon dioxide and epoxides. Also provided are methods of using such metal complexes in the synthesis of polymers. According to one aspect, the present invention provides metal complexes comprising an activating species with co-catalytic activity tethered to a multidentate ligand that is coordinated to the active metal center of the complex.

专利号:US-9693999-B2
优先权日:2011-01-26
标题:Small molecule RNase inhibitors and methods of use
发明人：DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE
权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education
摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

专利号:WO-2018228997-A1
优先权日:2017-06-12
标 题 :Immune cell modulation through cardiolipin synthesis
发明人：PEARCE ERIKA; CORRADO MAURO
权利人:MAX PLANCK GESELLSCHAFT
摘要:The present invention relates to a method for determining whether a compound has the capability of inhibiting cardiolipin synthesis, comprising (a) contacting a sample comprising T cells and/or M2 macrophages with the compound; (b) culturing the sample in the presence of the compound for at least 48h, preferably at least 60h and most preferably at least 72h; and (c) assaying in the sample the mitochondrial function of the T cells and/or M2 macrophages, wherein a reduction of the mitochondrial function as compared to a control sample not contacted with the compound indicates that the compound has the capability of inhibiting cardiolipin synthesis.

专利号:US-7795374-B2
优先权日:2007-04-17
标题 :Polyquarternium-1 synthesis methods
发明人：YU ZHI-JIAN
权利人:ABBOTT MEDICAL OPTICS INC
摘要:A method of making antimicrobial quaternary ammonium polymers, comprising: a) mixing 1,4-bis-dimethylamino-2-butene, water, a first portion of triethanolamine and a first portion of acid; b) adding a 1,4-dihalo-2-butene and heating the reaction mixture; c) adding a second portion of triethanolamine and a second portion of acid, and d) isolating a quaternary ammonium polymer having a molecular weight of at least 26 k.

专利号:WO-2009056955-A1
优先权日:2007-10-30
标题 :Amine-bearing phospholipids (abps), their synthesis and use
发明人：ZUMBUEHL ANDREAS
权利人:UNIV BASEL; ZUMBUEHL ANDREAS
摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

专利号:US-9868747-B2
优先权日:2014-02-18
标题:Marinopyrrole derivatives and methods of making and using same
发明人：LI RONGSHI; SEBTI SAID; LIU YAN; QIN YONG; SONG HAO; CHENG CHUNWEI
权利人:H LEE MOFFITT CANCER CT & RES; CHONGQING ZEIN PHARMACEUTICAL CO LTD
摘要:Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.