CAS: 2221-00-3; 4-Imidazol-1-Yl-Phenylamine
该化合物是有机化合物,其特征是有一种有刺状和无脊椎功能组,该化合物一般是固态的,在极地溶剂中溶解,反映其因氨基和伊米达佐尔组而进行氢联结的能力.该聚氨酯环有助于其作为协调化学中的悬浮体的潜力,而该聚氨酯部分可以参与各种化学反应,包括电光学替代.该聚氨可展示生物活动,可用于合成更复杂的分子,因此该聚氨酯结构允许与生物目标进行潜在互动,成为药物开发进一步研究的候选物.应参考安全数据,以便处理和使用,如任何化学物质,确保采取适当的预防措施.
物理性质
MSDS等安全信息
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CAS号288-32-4 咪唑 | CAS号106-40-1 对溴苯胺 | CAS号540-37-4 对碘苯胺 | CAS号2301-25-9 1-(4-硝基苯)-1H-咪唑 | CAS号51581-54-5 1-(4-氯苯基)咪唑 | CAS号7772-99-8 无水氯化亚锡 | CAS号350-46-9 对氟硝基苯 | CAS号647835-36-7 2,6-dibromo-4-i... | CAS号647835-37-8 4-imidazol-1-yl... | CAS号647835-45-8 2,6-bis(4-chlor...合成工艺路线路线简述
📜对硝基氯苯置于ammonium Hydroxide,Sodium Dithionite,Aliquat(At)366,Potassium Carbonate体系中,用 水,N,N-二甲基甲酰胺 用作溶剂,化学反应 24.25H,反应生成4-(1H-咪唑-1-基)苯胺
参考文献:Design,Synthesis,3D Pharmacophore,Qsar,And Docking Studies Of Carboxylic Acid Derivatives As Histone Deacetylase Inhibitors And Cytotoxic Agents
标题:Design,Synthesis,3D Pharmacophore,Qsar,And Docking Studies Of Carboxylic Acid Derivatives As Histone Deacetylase Inhibitors And Cytotoxic Agents
摘要:In This Study,Five Series Of (E)-6-(4-Substituted Phenyl)-4-Oxohex-5-Enoic Acids Iib-F (E),(E)-3-(4-(Substituted)-Phenyl) Acrylic Acids Iiia-G (E),4-(4-(Substituted) Phenylamino)-4-Oxobutanoic Acids Via,B,E,5-(4-(Substituted) Phenylamino)-5-Oxopentanoic Acids Viia,F And 2-[(4-(Substituted) Phenyl) Carbamoyl] Benzoic Acids Viiia,E Were Designed And Synthesized. Selected Compounds Were Screened In Vitro For Their Cytotoxic Effect On 60 Human Nci Tumor Cell Lines. Compound Iif (E) Displayed Significant Inhibitory Activity Against Nci Non-Small Cell Lung A549/atcc Cancer Cell Line (68% Inhibition) And Nci-H460 Cancer Cell Line (66% Inhibition). Moreover,The Final Compounds Were Evaluated In Vitro For Their Cytotoxic Activity On Hepg2 Cancer Cell Line In Which Histone Deacetylase (Hdac) Is Overexpressed. Compounds Iic (E),Iif (E),Iiib (E),And Iiig (E) Exhibited The Highest Cytotoxic Activity Against Hepg2 Human Cancer Cell Lines With Ic50 Ranging From 2.27 To 10.71 Mu M. In Addition,Selected Compounds Were Tested On Histone Deacetylase Isoforms (Hdac1-11). Molecular Docking Simulation Was Also Carried Out For Hdlp Enzyme To Investigate Their Hdac Binding Affinity. In Addition,Generation Of 3D-Pharmacophore Model And Quantitative Structure Activity Relationship (Qsar) Models Were Combined To Explore The Structural Requirements Controlling The Observed Cytotoxic Properties. (C) 2014 Elsevier Inc. All Rights Reserved.
Doi:10.1016/j.Bioorg.2014.08.006
专利信息
专利号:US-10458995-B2
优先权日:2016-03-25
标 题 :Combinatorial synthesis and biomarker development
发明人：MOOLA MURALIDHAR REDDY
权利人:MOOLA MURALIDHAR REDDY
摘要:Provided herein are methods, kits, and compositions for use in the diagnosis and treatment of diseases. Peptoids recognized by Alzheimers disease specific antibodies are identified.
专利号:CN-113214480-A
优先权日:2021-03-25
标题 :Synthesis method and adsorption application of a cationic framework material
专利号:CN-113214480-B
优先权日:2021-03-25
标题:Synthesis method and adsorption application of cationic framework material
专利号:CN-114573827-A
优先权日:2022-03-14
标 题 :Synthesis and Adsorption Application of an Alkali-Resistant Halogen Bond Donor Metal-Organic Framework
专利号:CN-114736385-A
优先权日:2022-03-25
标题 :Synthesis and Adsorption Application of an Alkali-Resistant Halogen Bond Donor Metal-Organic Framework
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合成参考文献
摘要:Ahmad, O. K.; Movassaghi, M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 195.
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