CAS: 21230-50-2; 3-Amino-1-Methyl-1H-Pyrazole-4-Carbonitrile

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CAS号16617-46-2 3-氨基-4-氰基吡唑 | CAS号38327-03-6 N-[(4-methoxyph... | CAS号122-51-0 原甲酸三乙酯 | CAS号109-77-3 丙二腈 | CAS号74-88-4 碘甲烷 | CAS号10472-09-0 2-(chloromethyl... | CAS号60-34-4 甲基肼 | CAS号1224256-30-7 2-Methyl-6-phen...

📜{[(2Z)-2-Benzylidene-1-Methylhydrazino]Methylene}-Malononitrile置于盐酸体系中,用 水 用作溶剂,化学反应生成1-甲基-3-氨基-4-氰基吡唑
参考文献:Does The Combination Of Optimal Substitutions At The C2-,N5-And N8-Positions Of The Pyrazolo-Triazolo-Pyrimidine Scaffold Guarantee Selective Modulation Of The Human A3 Adenosine Receptors
标题:Does The Combination Of Optimal Substitutions At The C2-,N5-And N8-Positions Of The Pyrazolo-Triazolo-Pyrimidine Scaffold Guarantee Selective Modulation Of The Human A3 Adenosine Receptors
摘要:In An Attempt To Study The Optimal Combination Of A Phenyl Ring At The C-2-Position And Different Substituents At The N-5-And N-8-Positions Towards The Selective Modulation Of Human A(3) Adenosine Receptors (Ha(3)Ar),We Synthesized A New Series Of 2-Para-(Un)Substituted-Phenyl-Pyrazolo-Triazolo-Pyrimidines Bearing Either A Methyl Or Phenylethyl At N-8 And Chains Of Variable Length At N-5. Through Biological Evaluation,It Was Found That The Majority Of The Compounds Had Good Affinities Towards The Ha(3)Ar In The Low Nanomolar Range. Compound 16 Possessed The Best Ha(3)Ar Affinity And Selectivity Profile (K(I)Ha(3) = 1.33 Nm; Ha(1)/ha(3) = 4880; Ha(2A)/ha(3) = 1100) In The Present Series Of2-(Substituted)Phenylpyrazolo-Triazolo-Pyrimidine Derivatives. In Addition To Pharmacological Characterization,A Molecular Modeling Investigation On These Compounds Further Elucidated The Effect Of Different Substituents At The Pyrazolo-Triazolo-Pyrimidine Scaffold On Affinity And Selectivity To Ha3Ar. (C) 2011 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2011.08.026