CAS: 20781-06-0; 2,4-Diaminopyrimidine-5-Carbaldehyde

该化合物是一种有机化合物,其特点是其火水环结构,包含2和4位置的两个氨基组和5位置的一个水氧化甲基组,该化合物一般为白色至非白色固体,由于水和酒精等极溶剂的存在,可溶于水和酒精等极地溶剂中,可进行氢气结合;该乙醇在药物中的潜在应用经常受到研究,特别是作为合成各种生物活性分子的构件.氨基组的存在使得其在有机合成中成为多功能的中间体,允许进一步的功能化.此外,其结构特征可能有助于生物活动,使其对药用化学具有兴趣.在处理和储存时,应参考安全数据,如任何化学物质,以确保采取适当的防范措施.

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合成工艺路线路线简述

    📜(2,4-Diamino-Pyrimidin-5-Ylmethyl)-(2,4-Diamino-Pyrimidin-5-Ylmethylen)-Amine置于sodium Hydroxide体系中,化学反应生成2,4-二氨基嘧啶-5-甲醛
    参考文献:2,4-Diamino-5-(4-Methyl-5-β-Hydroxyethylthiazolium Chloride)-Methylpyrimidine Hydrochloride,A New Analog Of Thiamin
    标题:2,4-Diamino-5-(4-Methyl-5-β-Hydroxyethylthiazolium Chloride)-Methylpyrimidine Hydrochloride,A New Analog Of Thiamin
    摘要:
    Doi:10.1021/ja01251A060

    海关参考信息

    专利信息


    专利号:US-5484949-A
    优先权日:1993-01-29
    标题:Method for the synthesis of α β-unsaturated ketones
    发明人:TSUKASHIMA KEIICHI; NAKAJIMA MASASHI; FUJIMARU MASAYOSHI; SUZUKI KENJI
    权利人:NIPPON SODA CO
    摘要:The present invention relates to a method for the synthesis of alpha , beta -unsaturated ketones which comprises, in the method for the synthesis of alpha , beta -unsaturated ketones represented by general formula reacting aldehydes represented by general formula R1CHO (where R1 is as defined above) with alkali metal salt of acetoacetic acid represented by general formula sence as a catalyst of 3-azabicyclo[3,2,2]nonane, a cyclic secondary amine represented by general formula (1) (1) a cyclic secondary amine represented by general formula (2) (2) (where, l is 1 or more and up to 6, a ring with N is a 6-membered, 7-membered or 8-membered ring, the two neighbors of N are methylene, R3 is a lower alkyl group, its substitution position is at a carbon atom other than two those adjacent to N, and is an alicyclic group or a phenol group), or a secondary amine represented by general formula (3) CH3NHCH2R4(3) in a mixuture solvent of water and water-insoluble organic solvent, while keeping the pH constant with mineral acid, and by adjusting an amount of water.

    专利号:US-7429658-B2
    优先权日:2003-09-11
    标题 :Synthesis of protected pyrrolobenzodiazepines
    发明人:HOWARD PHILIP; MASTERSON LUKE
    权利人:SPIROGEN LTD
    摘要:A method of synthesis of a N-10 protected PBD compound of formula (I): n nvia an intermediate of formula (II) or formula (V):

    专利号:US-8283502-B2
    优先权日:2009-04-09
    标题:Autocatalytic process for the synthesis of chiral propargylic alcohols
    发明人:CHINKOV NICKA; WARM ALEKSANDER; CARREIRA ERICK
    权利人:CHINKOV NICKA; WARM ALEKSANDER; CARREIRA ERICK; LONZA AG
    摘要:An autocatalytic process for the synthesis of chiral propargylic alcohols.

    专利号:US-11629150-B2
    优先权日:2016-07-01
    标题:Synthesis of N-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines
    发明人:SMITH ALEXANDER; WHITE HANNAH S; TAVARES FRANCIS XAVIER; KRASUTSKY SERGIY; CHEN JIAN-XIE; DORROW ROBERTA L; ZHONG HUA
    权利人:G1 THERAPEUTICS INC
    摘要:This invention is in the area of synthesizing pyrimidine-based compounds useful in the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.

    专利号:US-2018171086-A1
    优先权日:2016-12-16
    标题 :Large area monolayer of perfluoro polymers
    发明人:SUN HAORAN
    权利人:SOUTH DAKOTA BOARD OF REGENTS
    摘要:Synthesis and growth of large area free-standing ultra-thin two-dimensional (2D) polymeric films including 2D covalent organic frameworks (COF) are achieved by utilizing fluorocarbon-soluble fluorinated aldehyde derivatives and hydrocarbon-soluble amine derivatives at a liquid-liquid interface of respective fluorocarbon and hydrocarbon solvents.

    专利号:US-2009326223-A1
    优先权日:2006-07-18
    标题 :Synthesis of 2-amino-substituted 4-oxo-4h-chromen-8.yl-trifluoro-methanesulfonic acid esters
    发明人:GRIFFIN ROGER JOHN; HARDCASTLE IAN ROBERT; DESAGE-EL MURR MARINE; RODRIGUEZ-ARISTEGUI SONSOLES; GOLDING BERNARD THOMAS
    权利人:GRIFFIN ROGER JOHN; HARDCASTLE IAN ROBERT; DESAGE-EL MURR MARINE; RODRIGUEZ-ARISTEGUI SONSOLES; GOLDING BERNARD THOMAS
    摘要:A method of synthesising a compound of formula (I): wherein R N1 and R N2 are independently selected from hydrogen, an optionally substituted C 1-7 alkyl group, C 3-20 heterocyclyl group, or C 5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; from a compound of formula (III): comprising the steps of: (a) removing the allyl group from the compound of formula (III) with appropriate reaction conditions to yield a compound of formula (II): and (b) reacting the compound of formula (II) with a triflating agent to yield a compound of formula (I).

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