专利号:US-RE31624-E 优先权日:1979-11-26 标 题 :Method of treating inflammation 摘要:A method of treating inflammation and inhibiting prostaglandin synthesis employing substituted 2-(arylmethoxy)phenol compounds.
专利号:US-4244956-A 优先权日:1979-11-26 标题 :Method of treating inflammation 发明人:DEWHIRST FLOYD E 权利人:FORSYTH DENTAL INFIRMARY 摘要:A method of treating inflammation and inhibiting prostaglandin synthesis employing substituted 2-(arylmethoxy)phenol compounds.
专利号:US-2014315915-A1 优先权日:2009-02-09 标题:Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs
专利号:US-9522901-B2 优先权日:2005-05-26 标题:Compositions and methods including cell death inducers and procaspase activation 发明人:HERGENROTHER PAUL J; PUTT KARSON S; PETERSON QUINN P; FAKO VALERIE 权利人:UNIV ILLINOIS 摘要:Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.
专利号:US-9643960-B2 优先权日:2009-02-09 标 题:Procaspase activating compounds 发明人:HERGENROTHER PAUL J; PETERSON QUINN PATRICK; HSU DANNY CHUNG; WEST DIANA C; FAN TIMOTHY M; NOVOTNY CHRIS J 权利人:UNIV ILLINOIS 摘要:Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed that have lower neurotoxicity effects than other compounds.
专利号:US-2012040995-A1 优先权日:2009-02-09 标 题:Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs
摘要:J. Epstein, R. E. Plapinger, H. O. Michel, J. R. Cable, R. A. Stephani, R. J. Hester, C. Billington and G. R. List, J. Am. Chem. Soc. 86, 3075 (1964). 摘要:T. Kappe and M.D. Armstrong. J. Med. Chem. 8, 368 (1965).